View in EDS HTML Full Text PDF Full Text

Applicability of S100B in the Screening of Intracranial Injury in Patients With Mild Traumatic Brain Injury Intoxicated With Alcohol.

Saved in:
Bibliographic Details
Title: Applicability of S100B in the Screening of Intracranial Injury in Patients With Mild Traumatic Brain Injury Intoxicated With Alcohol.
Authors: Vicens, J. (AUTHOR), Muñiz, Gomila (AUTHOR), Sánchez-Cuadrado, D. (AUTHOR), Servera, M. A. (AUTHOR), Pou, F. (AUTHOR), Sarubbo, F. (AUTHOR), Saleem, Suraiya (AUTHOR)
Source: Acta Neurologica Scandinavica. 4/30/2026, Vol. 2026, p1-8. 8p.
Subjects: Biomarkers, Brain injuries, Brain tomography, Hospital emergency services, Alcoholic intoxication, Sensitivity & specificity (Statistics)
Abstract: Background: Traumatic brain injury (TBI) frequently occurs in patients with ethanol intoxication (EOI), complicating cranial CT evaluation. Therefore, it is necessary to identify simple alternative biomarkers of intracranial lesions (ICL). This study assesses whether the biomarker S100B can help rule out ICL in patients with mild TBI and EOI, according to Scandinavian TBI guidelines. Method: An observational study with cross‐sectional data collection was conducted at Son Llàtzer University Hospital (HUSLL), in Palma de Mallorca, including patients aged 18–65 years who sustained mild TBI in the context of EOI (n = 116), had an inconclusive Glasgow Coma Scale (GCS) score, and presented to the Emergency Department within 6 h of injury. Blood samples were collected to measure S100B and blood alcohol levels. All patients underwent cranial CT (the gold standard). CT results (positive/negative for ICL) were compared with S100B values, dichotomized at ≤ 0.1 μg/L. Results: The primary objective was to analyze the relationship between S100B levels (≤ 0.1 μg/L vs. > 0.1 μg/L) and cranial CT results. In 97.8% of patients with a negative CT result, S100B levels were ≤ 0.1 μg/L. Conversely, among those with S100B > 0.1 μg/L, 12.7% had a positive CT result (χ2 = 3.82, df = 1, p = 0.04; OR = 6.38; 95%CI = 1.01–52.25). S100B demonstrated a high sensitivity of 90% for detecting ICL, with a specificity of 42%, a positive predictive value of 13%, and a negative predictive value of 98%. Conclusion: S100B appears to be a sensitive biomarker for ruling out ICL in mild TBI. Levels ≤ 0.1 μg/L were associated with negative CT findings, whereas higher levels showed limited positive predictive value. S100B may help reduce unnecessary CT imaging in low‐risk patients; however, its limited specificity requires interpretation within the clinical context. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 193398568
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Applicability of S100B in the Screening of Intracranial Injury in Patients With Mild Traumatic Brain Injury Intoxicated With Alcohol.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Vicens%2C+J%2E%22">Vicens, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Muñiz%2C+Gomila%22">Muñiz, Gomila</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sánchez-Cuadrado%2C+D%2E%22">Sánchez-Cuadrado, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Servera%2C+M%2E+A%2E%22">Servera, M. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pou%2C+F%2E%22">Pou, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sarubbo%2C+F%2E%22">Sarubbo, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saleem%2C+Suraiya%22">Saleem, Suraiya</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 4/30/2026, Vol. 2026, p1-8. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+injuries%22">Brain injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+tomography%22">Brain tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+emergency+services%22">Hospital emergency services</searchLink><br /><searchLink fieldCode="DE" term="%22Alcoholic+intoxication%22">Alcoholic intoxication</searchLink><br /><searchLink fieldCode="DE" term="%22Sensitivity+%26+specificity+%28Statistics%29%22">Sensitivity & specificity (Statistics)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Traumatic brain injury (TBI) frequently occurs in patients with ethanol intoxication (EOI), complicating cranial CT evaluation. Therefore, it is necessary to identify simple alternative biomarkers of intracranial lesions (ICL). This study assesses whether the biomarker S100B can help rule out ICL in patients with mild TBI and EOI, according to Scandinavian TBI guidelines. Method: An observational study with cross‐sectional data collection was conducted at Son Llàtzer University Hospital (HUSLL), in Palma de Mallorca, including patients aged 18–65 years who sustained mild TBI in the context of EOI (n = 116), had an inconclusive Glasgow Coma Scale (GCS) score, and presented to the Emergency Department within 6 h of injury. Blood samples were collected to measure S100B and blood alcohol levels. All patients underwent cranial CT (the gold standard). CT results (positive/negative for ICL) were compared with S100B values, dichotomized at ≤ 0.1 μg/L. Results: The primary objective was to analyze the relationship between S100B levels (≤ 0.1 μg/L vs. > 0.1 μg/L) and cranial CT results. In 97.8% of patients with a negative CT result, S100B levels were ≤ 0.1 μg/L. Conversely, among those with S100B > 0.1 μg/L, 12.7% had a positive CT result (χ2 = 3.82, df = 1, p = 0.04; OR = 6.38; 95%CI = 1.01–52.25). S100B demonstrated a high sensitivity of 90% for detecting ICL, with a specificity of 42%, a positive predictive value of 13%, and a negative predictive value of 98%. Conclusion: S100B appears to be a sensitive biomarker for ruling out ICL in mild TBI. Levels ≤ 0.1 μg/L were associated with negative CT findings, whereas higher levels showed limited positive predictive value. S100B may help reduce unnecessary CT imaging in low‐risk patients; however, its limited specificity requires interpretation within the clinical context. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=193398568
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1155/ane/8819203
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1
    Subjects:
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Brain injuries
        Type: general
      – SubjectFull: Brain tomography
        Type: general
      – SubjectFull: Hospital emergency services
        Type: general
      – SubjectFull: Alcoholic intoxication
        Type: general
      – SubjectFull: Sensitivity & specificity (Statistics)
        Type: general
    Titles:
      – TitleFull: Applicability of S100B in the Screening of Intracranial Injury in Patients With Mild Traumatic Brain Injury Intoxicated With Alcohol.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Vicens, J.
      – PersonEntity:
          Name:
            NameFull: Muñiz, Gomila
      – PersonEntity:
          Name:
            NameFull: Sánchez-Cuadrado, D.
      – PersonEntity:
          Name:
            NameFull: Servera, M. A.
      – PersonEntity:
          Name:
            NameFull: Pou, F.
      – PersonEntity:
          Name:
            NameFull: Sarubbo, F.
      – PersonEntity:
          Name:
            NameFull: Saleem, Suraiya
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 30
              M: 04
              Text: 4/30/2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 00016314
          Numbering:
            – Type: volume
              Value: 2026
          Titles:
            – TitleFull: Acta Neurologica Scandinavica
              Type: main
ResultId 1