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Enteric Viral Pathogens in Infants in the United States: 2017–2020.

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Title: Enteric Viral Pathogens in Infants in the United States: 2017–2020.
Authors: Cannon, Jennifer L. (AUTHOR), Baker, Julia M. (AUTHOR), Mattison, Claire P. (AUTHOR), Browne, Hannah (AUTHOR), Nguyen, Kenny (AUTHOR), Burke, Rachel M. (AUTHOR), Mijatovic-Rustempasic, Slavica (AUTHOR), Casey-Moore, Mary C. (AUTHOR), Gautam, Rashi (AUTHOR), Bartlett, Eddie (AUTHOR), Embury, Shane (AUTHOR), Burrell, Allison (AUTHOR), Conrey, Shannon (AUTHOR), Parashar, Umesh D. (AUTHOR), Payne, Daniel C. (AUTHOR), Staat, Mary Allen (AUTHOR), Morrow, Ardythe L. (AUTHOR), Vinjé, Jan (AUTHOR)
Source: Pediatrics. May2026, Vol. 157 Issue 5, p1-10. 1p.
Subjects: Immunization, Diarrhea, Acute diseases, Research funding, Feces, Rotaviruses, Seasons, Adenoviruses, Fisher exact test, Medical care, Emergency room visits, Reverse transcriptase polymerase chain reaction, Chi-squared test, Mann Whitney U Test, Descriptive statistics, Longitudinal method, RNA viruses, Hospital care of newborn infants, Viral vaccines, Gastroenteritis, Virus diseases, Comparative studies, Data analysis software, Vomiting, Genotypes, Microbial genetics, Disease incidence, Hospital care of children, Symptoms, Children
Geographic Terms: Ohio, United States
Abstract: OBJECTIVE: The introduction of rotavirus vaccines in the United States led to substantial reductions in rotavirus disease burden, whereas the relative burden of other viral pathogens causing acute gastroenteritis (AGE) increased. Our aim was to establish the community-level burden of enteric viral pathogens in a US cohort during the first 2 years of life. METHODS: From birth until age 2 years, weekly stools and AGE symptom surveys were collected from mother-child pairs in the PREVAIL (Pediatric Respiratory & Enteric Virus Acquisition and Immunogenesis Longitudinal) cohort. Stools were tested for 5 enteric viral pathogens, with infections defined by grouping proximal viral detections with the same genotype. Rates of infection and AGE symptoms were determined. RESULTS: From 2017 to 2020, 245 children were followed, with 13 944 stools tested and 836 episodes of AGE recorded. Children had 3.8 enteric viral infections per child-year and over two-thirds had 1 or more symptomatic enteric viral infection by age 2 years. Norovirus Genogroup II (0.4 per child-year) and sapovirus (0.2 per child-year) had the highest incidence of symptomatic infections, followed by astrovirus, rotavirus, norovirus Genogroup I, and adenovirus 40/41 (each ≤0.1 per child-year). Approximately two-thirds of enteric viral infections were asymptomatic, and 90% were not medically attended. Symptomatic infections were infrequent before age 6 months. CONCLUSION: Our findings show the high burden of symptomatic enteric viral infections, particularly norovirus, as well as the high frequency of asymptomatic infections, thereby improving our understanding of the epidemiology and clinical manifestations of enteric viral infections in young US children. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Enteric Viral Pathogens in Infants in the United States: 2017–2020.
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  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. May2026, Vol. 157 Issue 5, p1-10. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Immunization%22">Immunization</searchLink><br /><searchLink fieldCode="DE" term="%22Diarrhea%22">Diarrhea</searchLink><br /><searchLink fieldCode="DE" term="%22Acute+diseases%22">Acute diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Feces%22">Feces</searchLink><br /><searchLink fieldCode="DE" term="%22Rotaviruses%22">Rotaviruses</searchLink><br /><searchLink fieldCode="DE" term="%22Seasons%22">Seasons</searchLink><br /><searchLink fieldCode="DE" term="%22Adenoviruses%22">Adenoviruses</searchLink><br /><searchLink fieldCode="DE" term="%22Fisher+exact+test%22">Fisher exact test</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+care%22">Medical care</searchLink><br /><searchLink fieldCode="DE" term="%22Emergency+room+visits%22">Emergency room visits</searchLink><br /><searchLink fieldCode="DE" term="%22Reverse+transcriptase+polymerase+chain+reaction%22">Reverse transcriptase polymerase chain reaction</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Mann+Whitney+U+Test%22">Mann Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+viruses%22">RNA viruses</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+care+of+newborn+infants%22">Hospital care of newborn infants</searchLink><br /><searchLink fieldCode="DE" term="%22Viral+vaccines%22">Viral vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22Gastroenteritis%22">Gastroenteritis</searchLink><br /><searchLink fieldCode="DE" term="%22Virus+diseases%22">Virus diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Vomiting%22">Vomiting</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Microbial+genetics%22">Microbial genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+incidence%22">Disease incidence</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+care+of+children%22">Hospital care of children</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink>
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– Name: Abstract
  Label: Abstract
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  Data: OBJECTIVE: The introduction of rotavirus vaccines in the United States led to substantial reductions in rotavirus disease burden, whereas the relative burden of other viral pathogens causing acute gastroenteritis (AGE) increased. Our aim was to establish the community-level burden of enteric viral pathogens in a US cohort during the first 2 years of life. METHODS: From birth until age 2 years, weekly stools and AGE symptom surveys were collected from mother-child pairs in the PREVAIL (Pediatric Respiratory & Enteric Virus Acquisition and Immunogenesis Longitudinal) cohort. Stools were tested for 5 enteric viral pathogens, with infections defined by grouping proximal viral detections with the same genotype. Rates of infection and AGE symptoms were determined. RESULTS: From 2017 to 2020, 245 children were followed, with 13 944 stools tested and 836 episodes of AGE recorded. Children had 3.8 enteric viral infections per child-year and over two-thirds had 1 or more symptomatic enteric viral infection by age 2 years. Norovirus Genogroup II (0.4 per child-year) and sapovirus (0.2 per child-year) had the highest incidence of symptomatic infections, followed by astrovirus, rotavirus, norovirus Genogroup I, and adenovirus 40/41 (each ≤0.1 per child-year). Approximately two-thirds of enteric viral infections were asymptomatic, and 90% were not medically attended. Symptomatic infections were infrequent before age 6 months. CONCLUSION: Our findings show the high burden of symptomatic enteric viral infections, particularly norovirus, as well as the high frequency of asymptomatic infections, thereby improving our understanding of the epidemiology and clinical manifestations of enteric viral infections in young US children. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=193469254
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1542/peds.2025-072461
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      – Code: eng
        Text: English
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      – SubjectFull: Immunization
        Type: general
      – SubjectFull: Diarrhea
        Type: general
      – SubjectFull: Acute diseases
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      – SubjectFull: Reverse transcriptase polymerase chain reaction
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      – SubjectFull: Children
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      – SubjectFull: Ohio
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      – SubjectFull: United States
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