Increased Peak Width of Skeletonized Mean Diffusivity in Status Epilepticus: Implication for Diffuse White Matter Microstructural Alteration.
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| Title: | Increased Peak Width of Skeletonized Mean Diffusivity in Status Epilepticus: Implication for Diffuse White Matter Microstructural Alteration. |
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| Authors: | Kim, Jinseung (AUTHOR), Lee, Dong Ah. (AUTHOR), Lee, Ho-Joon (AUTHOR), Park, Kang Min (AUTHOR), Dhoundiyal, Ankit (AUTHOR) |
| Source: | Acta Neurologica Scandinavica. 5/6/2026, Vol. 2026, p1-7. 7p. |
| Subjects: | Status epilepticus, Biomarkers, Diffusion tensor imaging, Magnetic resonance imaging, Cerebral small vessel diseases, Computer-assisted image analysis (Medicine), Leukoencephalopathies, Brain imaging |
| Abstract: | Objectives: Peak width of skeletonized mean diffusivity (PSMD) serves as a new biomarker for diffuse white matter microstructural damage. This study is aimed at quantifying PSMD in patients with status epilepticus (SE) to investigate white matter microstructural abnormalities and their potential association with small vessel disease (SVD) mechanisms in SE. Methods: We retrospectively enrolled patients with SE and healthy controls matched for age and sex. Diffusion tensor imaging (DTI) was performed using a 3.0 Tesla magnetic resonance imaging scanner to measure PSMD. We compared the PSMD values between patients with SE and healthy controls. Additionally, we analyzed correlations between PSMD and clinical factors in patients with SE. Results: Twenty‐eight patients with SE and 31 healthy controls were included in this study. PSMD values were significantly higher in patients with SE compared with controls (3.024 vs. 2.257, p < 0.001). Additionally, in patients with SE, PSMD positively correlated with age (r = 0.721, p < 0.001). However, PSMD was not significantly correlated with other clinical characteristics, including the duration of SE and the number of antiseizure medications (r = 0.031, p = 0.876; r = −0.340, p = 0.076, respectively). Conclusion: Patients with SE exhibited significantly elevated PSMD, which was associated with white matter microstructural abnormalities. These findings suggested that PSMD may be a useful imaging marker for assessing white matter changes in SE and warrant further investigation into its association with underlying vascular and nonvascular mechanisms. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 193520464 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Increased Peak Width of Skeletonized Mean Diffusivity in Status Epilepticus: Implication for Diffuse White Matter Microstructural Alteration. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kim%2C+Jinseung%22">Kim, Jinseung</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Dong+Ah%2E%22">Lee, Dong Ah.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Ho-Joon%22">Lee, Ho-Joon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Kang+Min%22">Park, Kang Min</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dhoundiyal%2C+Ankit%22">Dhoundiyal, Ankit</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 5/6/2026, Vol. 2026, p1-7. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Status+epilepticus%22">Status epilepticus</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+tensor+imaging%22">Diffusion tensor imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+small+vessel+diseases%22">Cerebral small vessel diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Computer-assisted+image+analysis+%28Medicine%29%22">Computer-assisted image analysis (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Leukoencephalopathies%22">Leukoencephalopathies</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: Peak width of skeletonized mean diffusivity (PSMD) serves as a new biomarker for diffuse white matter microstructural damage. This study is aimed at quantifying PSMD in patients with status epilepticus (SE) to investigate white matter microstructural abnormalities and their potential association with small vessel disease (SVD) mechanisms in SE. Methods: We retrospectively enrolled patients with SE and healthy controls matched for age and sex. Diffusion tensor imaging (DTI) was performed using a 3.0 Tesla magnetic resonance imaging scanner to measure PSMD. We compared the PSMD values between patients with SE and healthy controls. Additionally, we analyzed correlations between PSMD and clinical factors in patients with SE. Results: Twenty‐eight patients with SE and 31 healthy controls were included in this study. PSMD values were significantly higher in patients with SE compared with controls (3.024 vs. 2.257, p < 0.001). Additionally, in patients with SE, PSMD positively correlated with age (r = 0.721, p < 0.001). However, PSMD was not significantly correlated with other clinical characteristics, including the duration of SE and the number of antiseizure medications (r = 0.031, p = 0.876; r = −0.340, p = 0.076, respectively). Conclusion: Patients with SE exhibited significantly elevated PSMD, which was associated with white matter microstructural abnormalities. These findings suggested that PSMD may be a useful imaging marker for assessing white matter changes in SE and warrant further investigation into its association with underlying vascular and nonvascular mechanisms. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1155/ane/7155788 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 1 Subjects: – SubjectFull: Status epilepticus Type: general – SubjectFull: Biomarkers Type: general – SubjectFull: Diffusion tensor imaging Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Cerebral small vessel diseases Type: general – SubjectFull: Computer-assisted image analysis (Medicine) Type: general – SubjectFull: Leukoencephalopathies Type: general – SubjectFull: Brain imaging Type: general Titles: – TitleFull: Increased Peak Width of Skeletonized Mean Diffusivity in Status Epilepticus: Implication for Diffuse White Matter Microstructural Alteration. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kim, Jinseung – PersonEntity: Name: NameFull: Lee, Dong Ah. – PersonEntity: Name: NameFull: Lee, Ho-Joon – PersonEntity: Name: NameFull: Park, Kang Min – PersonEntity: Name: NameFull: Dhoundiyal, Ankit IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 05 Text: 5/6/2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00016314 Numbering: – Type: volume Value: 2026 Titles: – TitleFull: Acta Neurologica Scandinavica Type: main |
| ResultId | 1 |
