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Restoring Homeostatic Balance: Advances in Traditional Chinese Medicine for Rheumatoid Arthritis.

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Title: Restoring Homeostatic Balance: Advances in Traditional Chinese Medicine for Rheumatoid Arthritis.
Authors: Xiang, Yuhong (AUTHOR), Yang, Aihong (AUTHOR), Guo, Cong (AUTHOR), Cheng, Jintang (AUTHOR), Zhang, Jun (AUTHOR), Chen, Chang (AUTHOR), Chen, Sha (AUTHOR), Jiang, Jinzhu (AUTHOR), Di, Jipeng (AUTHOR), Liu, Xianju (AUTHOR), Li, Siyuan (AUTHOR), Liu, An (AUTHOR), Liu, Yan (AUTHOR), Xu, Qingxia (AUTHOR)
Source: American Journal of Chinese Medicine. 2026, Vol. 54 Issue 3, p733-762. 30p.
Subjects: Inflammation prevention, Chinese medicine, Homeostasis, Osteoblasts, Macrophages, Autophagy, Rheumatoid arthritis, Herbal medicine, Gut microbiota, Oxidative stress, Reactive oxygen species, Osteoclasts, Pathologic neovascularization, Disease progression
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease with inflammation-mediated joint damage. Its pathogenesis involves synergistic impairment of multiple physiological balances, including immune cell subset dysregulation, abnormal inflammation, oxidative stress, pathological angiogenesis, bone homeostasis disorder and gut microbiota dysbiosis. Conventional therapies have high costs and adverse effects. Traditional Chinese medicine (TCM) follows a holistic balance-restoring concept and is a promising alternative, with Tripterygium wilfordii, Wutou Decoction and Toddalia asiatica extract as evidence-based representatives. This review summarizes 2020–2025 in vitro and in vivo studies on anti-RA TCM. Its core therapeutic mechanism is multi-target, network-based regulation. It rectifies various pathological imbalances simultaneously: modulating immune cell polarization, rebalancing inflammatory factors, scavenging ROS, inhibiting abnormal angiogenesis, regulating osteoblast-osteoclast crosstalk and reshaping gut microbiota. Single TCM agents act on multiple balance networks, showing complex pharmacological properties. TCM's unique advantage for RA is reestablishing the body's dynamic homeostasis by targeting interconnected pathological balances. Further research is needed to clarify TCM components' synergistic regulatory mechanisms and promote their clinical translation. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Restoring Homeostatic Balance: Advances in Traditional Chinese Medicine for Rheumatoid Arthritis.
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  Data: <searchLink fieldCode="AR" term="%22Xiang%2C+Yuhong%22">Xiang, Yuhong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Aihong%22">Yang, Aihong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Cong%22">Guo, Cong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Jintang%22">Cheng, Jintang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jun%22">Zhang, Jun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Chang%22">Chen, Chang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Sha%22">Chen, Sha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Jinzhu%22">Jiang, Jinzhu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Di%2C+Jipeng%22">Di, Jipeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Xianju%22">Liu, Xianju</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Siyuan%22">Li, Siyuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+An%22">Liu, An</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Yan%22">Liu, Yan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Qingxia%22">Xu, Qingxia</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2026, Vol. 54 Issue 3, p733-762. 30p.
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  Data: <searchLink fieldCode="DE" term="%22Inflammation+prevention%22">Inflammation prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Chinese+medicine%22">Chinese medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Homeostasis%22">Homeostasis</searchLink><br /><searchLink fieldCode="DE" term="%22Osteoblasts%22">Osteoblasts</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophages%22">Macrophages</searchLink><br /><searchLink fieldCode="DE" term="%22Autophagy%22">Autophagy</searchLink><br /><searchLink fieldCode="DE" term="%22Rheumatoid+arthritis%22">Rheumatoid arthritis</searchLink><br /><searchLink fieldCode="DE" term="%22Herbal+medicine%22">Herbal medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Gut+microbiota%22">Gut microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22Osteoclasts%22">Osteoclasts</searchLink><br /><searchLink fieldCode="DE" term="%22Pathologic+neovascularization%22">Pathologic neovascularization</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+progression%22">Disease progression</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Rheumatoid arthritis (RA) is a chronic autoimmune disease with inflammation-mediated joint damage. Its pathogenesis involves synergistic impairment of multiple physiological balances, including immune cell subset dysregulation, abnormal inflammation, oxidative stress, pathological angiogenesis, bone homeostasis disorder and gut microbiota dysbiosis. Conventional therapies have high costs and adverse effects. Traditional Chinese medicine (TCM) follows a holistic balance-restoring concept and is a promising alternative, with Tripterygium wilfordii, Wutou Decoction and Toddalia asiatica extract as evidence-based representatives. This review summarizes 2020–2025 in vitro and in vivo studies on anti-RA TCM. Its core therapeutic mechanism is multi-target, network-based regulation. It rectifies various pathological imbalances simultaneously: modulating immune cell polarization, rebalancing inflammatory factors, scavenging ROS, inhibiting abnormal angiogenesis, regulating osteoblast-osteoclast crosstalk and reshaping gut microbiota. Single TCM agents act on multiple balance networks, showing complex pharmacological properties. TCM's unique advantage for RA is reestablishing the body's dynamic homeostasis by targeting interconnected pathological balances. Further research is needed to clarify TCM components' synergistic regulatory mechanisms and promote their clinical translation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1142/S0192415X26500278
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      – Code: eng
        Text: English
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        PageCount: 30
        StartPage: 733
    Subjects:
      – SubjectFull: Inflammation prevention
        Type: general
      – SubjectFull: Chinese medicine
        Type: general
      – SubjectFull: Homeostasis
        Type: general
      – SubjectFull: Osteoblasts
        Type: general
      – SubjectFull: Macrophages
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      – SubjectFull: Autophagy
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      – SubjectFull: Rheumatoid arthritis
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      – SubjectFull: Herbal medicine
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      – SubjectFull: Gut microbiota
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      – SubjectFull: Oxidative stress
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      – SubjectFull: Reactive oxygen species
        Type: general
      – SubjectFull: Osteoclasts
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      – SubjectFull: Pathologic neovascularization
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      – SubjectFull: Disease progression
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      – TitleFull: Restoring Homeostatic Balance: Advances in Traditional Chinese Medicine for Rheumatoid Arthritis.
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              Text: 2026
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