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Naloxone Availability, Testing Drugs for Potency, and Solitary Use: Unpacking the Determinants of Overdose Prevention Behaviors.

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Title: Naloxone Availability, Testing Drugs for Potency, and Solitary Use: Unpacking the Determinants of Overdose Prevention Behaviors.
Authors: Latkin, Carl. A. (AUTHOR), Dayton, Lauren (AUTHOR), Bonneau, Haley (AUTHOR), Davey-Rothwell, Melissa A. (AUTHOR), Santos-Silva, Leane (AUTHOR), Yi, Grace (AUTHOR), Falade-Nwulia, Oluwaseun (AUTHOR)
Source: Substance Use & Misuse. 2026, Vol. 61 Issue 8, p1185-1191. 7p.
Subjects: Drug overdose, Cross-sectional method, Social determinants of health, Research funding, Sex distribution, Multiple regression analysis, Descriptive statistics, Harm reduction, Drug use testing, Surveys, Race, Odds ratio, Narcotics, Social networks, Statistics, Naloxone, Data analysis software, Confidence intervals
Geographic Terms: Maryland
Abstract: Background: Fatal and nonfatal opioid overdoses remain a pressing public health challenge. However, engagement in drug overdose prevention and response behaviors may vary across demographic and social contexts. Objectives: This study examines individual and social determinants of these behaviors among people who use opioids (PWUO), leveraging data from the OASIS study in Baltimore, Maryland (N = 783). Ordered logistic regression models assessed factors associated with three key behaviors: testing-dosing to assess drug potency, naloxone availability while using with others, and solitary drug use. Results: The three key overdose prevention behaviors were not strongly correlated with one another. Racial disparities emerged, with Black participants more likely to engage in test-dosing compared to White participants. Gender differences were also notable, with women less likely to use with others who have naloxone available when using drugs. Social network factors played a key role; having a "running buddy" was strongly protective against solitary drug use. Conclusions: These findings underscore the importance of tailored harm reduction interventions that address racial and gender disparities, enhance social networks, manage withdrawal, and enhance naloxone availability. Integrating harm reduction skill training into peer-driven naloxone distribution and overdose prevention programs, training non-drug-using network members, and addressing structural barriers may enhance overdose prevention strategies. [ABSTRACT FROM AUTHOR]
Copyright of Substance Use & Misuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Naloxone Availability, Testing Drugs for Potency, and Solitary Use: Unpacking the Determinants of Overdose Prevention Behaviors.
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  Data: <searchLink fieldCode="JN" term="%22Substance+Use+%26+Misuse%22">Substance Use & Misuse</searchLink>. 2026, Vol. 61 Issue 8, p1185-1191. 7p.
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  Data: Background: Fatal and nonfatal opioid overdoses remain a pressing public health challenge. However, engagement in drug overdose prevention and response behaviors may vary across demographic and social contexts. Objectives: This study examines individual and social determinants of these behaviors among people who use opioids (PWUO), leveraging data from the OASIS study in Baltimore, Maryland (N = 783). Ordered logistic regression models assessed factors associated with three key behaviors: testing-dosing to assess drug potency, naloxone availability while using with others, and solitary drug use. Results: The three key overdose prevention behaviors were not strongly correlated with one another. Racial disparities emerged, with Black participants more likely to engage in test-dosing compared to White participants. Gender differences were also notable, with women less likely to use with others who have naloxone available when using drugs. Social network factors played a key role; having a "running buddy" was strongly protective against solitary drug use. Conclusions: These findings underscore the importance of tailored harm reduction interventions that address racial and gender disparities, enhance social networks, manage withdrawal, and enhance naloxone availability. Integrating harm reduction skill training into peer-driven naloxone distribution and overdose prevention programs, training non-drug-using network members, and addressing structural barriers may enhance overdose prevention strategies. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Substance Use & Misuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=193623157
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/10826084.2025.2600637
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
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        PageCount: 7
        StartPage: 1185
    Subjects:
      – SubjectFull: Drug overdose
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Social determinants of health
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Descriptive statistics
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      – SubjectFull: Harm reduction
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      – SubjectFull: Drug use testing
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      – SubjectFull: Surveys
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      – SubjectFull: Race
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      – SubjectFull: Odds ratio
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      – SubjectFull: Narcotics
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      – SubjectFull: Social networks
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      – SubjectFull: Statistics
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      – SubjectFull: Naloxone
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      – SubjectFull: Data analysis software
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      – SubjectFull: Confidence intervals
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      – SubjectFull: Maryland
        Type: general
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      – TitleFull: Naloxone Availability, Testing Drugs for Potency, and Solitary Use: Unpacking the Determinants of Overdose Prevention Behaviors.
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              Text: 2026
              Type: published
              Y: 2026
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