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Impact of primary cochlear implantation packing materials on reimplantation surgical difficulty and histopathological outcomes: a retrospective cohort study.

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Title: Impact of primary cochlear implantation packing materials on reimplantation surgical difficulty and histopathological outcomes: a retrospective cohort study.
Authors: Liu, Yuanjun (AUTHOR), Zhang, Jilei (AUTHOR), Cao, Jie (AUTHOR), Yu, Lisheng (AUTHOR), Han, Lin (AUTHOR)
Source: Acta Oto-Laryngologica. Apr2026, Vol. 146 Issue 4, p478-484. 7p.
Subjects: Prevention of surgical complications, Cochlear implants, Foreign body reaction, Pearson correlation (Statistics), Hyperplasia, T-test (Statistics), Complications of prosthesis, Sensorineural hearing loss, Fisher exact test, Tissue adhesions, Treatment effectiveness, Retrospective studies, Chi-squared test, Mann Whitney U Test, Descriptive statistics, Biomedical materials, Longitudinal method, Granulation tissue, Metaplastic ossification, Reoperation, Medical records, Acquisition of data, Hearing, Data analysis software
Abstract (English): Background: Cochlear implantation (CI) is the first choice for the treatment of severe to profound sensorineural hearing loss. This study evaluated the impact of primary CI packing materials on intraoperative findings and surgical outcomes in subsequent reimplantation. Aims/Objectives: To identify strategies that minimize adverse tissue reactions, reduce reimplantation difficulty, and maximize success rates. Material and Methods: In a retrospective cohort study of 77 cochlear reimplantations, patients were stratified into packing or non-packing groups based on material presence at reimplantation. Baseline characteristics, intraoperative findings, and prognostic outcomes were analyzed and compared. Results: Statistically significant differences were observed between the packing and non-packing groups regarding the presence of fibrous adhesion within the mastoid cavity (p = 0.016), facial recess bone hyperplasia (p < 0.001), granulation tissue formation (p < 0.001), cochlear ossification (p < 0.001), and the need for cochleostomy re-expansion (p = 0.001). The mean Categories of Auditory Performance score was lower in the packing group (4.75) compared to the non-packing group (5.16); however, this difference was not statistically significant (p = 0.192). Conclusions and Significance: Residual packing materials from primary CI increase intraoperative complexity during revision surgery, potentially compromising procedural success. Minimizing non-essential packing material use during initial implantation is strongly recommended to facilitate future revisions. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 慢性鼻窦炎 (CRS) 的症状很常见。并非所有患者都能通过计算机断层扫描 (CT) 和内镜检查来确诊。鼻腔一氧化氮 (nNO) 可检测鼻窦开口阻塞, 但其临床意义尚不明确。 我们评估了 nNO、鼻窦结果测试 22 (SNOT-22) 和 Zinreich 改良 Lund-Mackay (ZL-M) CT-评分是否与 CRS 或复发性急性鼻窦炎 (RARS) 患者的后续手术相关。 本前瞻性研究纳入了 66 例 CRS(伴/不伴鼻息肉)或 RARS 患者。所有患者均接受了至少 2 个月的适当药物治疗。患者在连续三次就诊期间接受评估: 在当前处方用药期间、在停药后以及在鼻内使用丙酸氟替卡松后。临床医生在进行后续治疗决策时并不知晓鼻腔一氧化氮(nNO)检测结果。 nNO 检测结果对决定是否进行手术干预的阳性预测值(PPV)为 76%, 阴性预测值(NPV)为 80%。这些结果与 ZL-M 评分(PPV 76%；NPV 82%)的结果无统计学显著差异。 慢性鼻窦炎(CRS)症状患者的低 nNO 水平与决定手术较晚相关。nNO 检测结果在指导初级保健机构转诊至耳鼻喉科方面的适用性还应进一步评估。 [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Impact of primary cochlear implantation packing materials on reimplantation surgical difficulty and histopathological outcomes: a retrospective cohort study.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Liu%2C+Yuanjun%22&quot;&gt;Liu, Yuanjun&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Jilei%22&quot;&gt;Zhang, Jilei&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cao%2C+Jie%22&quot;&gt;Cao, Jie&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yu%2C+Lisheng%22&quot;&gt;Yu, Lisheng&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Han%2C+Lin%22&quot;&gt;Han, Lin&lt;/searchLink&gt; (AUTHOR)
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– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Background: Cochlear implantation (CI) is the first choice for the treatment of severe to profound sensorineural hearing loss. This study evaluated the impact of primary CI packing materials on intraoperative findings and surgical outcomes in subsequent reimplantation. Aims/Objectives: To identify strategies that minimize adverse tissue reactions, reduce reimplantation difficulty, and maximize success rates. Material and Methods: In a retrospective cohort study of 77 cochlear reimplantations, patients were stratified into packing or non-packing groups based on material presence at reimplantation. Baseline characteristics, intraoperative findings, and prognostic outcomes were analyzed and compared. Results: Statistically significant differences were observed between the packing and non-packing groups regarding the presence of fibrous adhesion within the mastoid cavity (p = 0.016), facial recess bone hyperplasia (p &lt; 0.001), granulation tissue formation (p &lt; 0.001), cochlear ossification (p &lt; 0.001), and the need for cochleostomy re-expansion (p = 0.001). The mean Categories of Auditory Performance score was lower in the packing group (4.75) compared to the non-packing group (5.16); however, this difference was not statistically significant (p = 0.192). Conclusions and Significance: Residual packing materials from primary CI increase intraoperative complexity during revision surgery, potentially compromising procedural success. Minimizing non-essential packing material use during initial implantation is strongly recommended to facilitate future revisions. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Chinese)
  Group: Ab
  Data: 慢性鼻窦炎 (CRS) 的症状很常见。并非所有患者都能通过计算机断层扫描 (CT) 和内镜检查来确诊。鼻腔一氧化氮 (nNO) 可检测鼻窦开口阻塞, 但其临床意义尚不明确。 我们评估了 nNO、鼻窦结果测试 22 (SNOT-22) 和 Zinreich 改良 Lund-Mackay (ZL-M) CT-评分是否与 CRS 或复发性急性鼻窦炎 (RARS) 患者的后续手术相关。 本前瞻性研究纳入了 66 例 CRS(伴/不伴鼻息肉)或 RARS 患者。所有患者均接受了至少 2 个月的适当药物治疗。患者在连续三次就诊期间接受评估: 在当前处方用药期间、在停药后以及在鼻内使用丙酸氟替卡松后。临床医生在进行后续治疗决策时并不知晓鼻腔一氧化氮(nNO)检测结果。 nNO 检测结果对决定是否进行手术干预的阳性预测值(PPV)为 76%, 阴性预测值(NPV)为 80%。这些结果与 ZL-M 评分(PPV 76%；NPV 82%)的结果无统计学显著差异。 慢性鼻窦炎(CRS)症状患者的低 nNO 水平与决定手术较晚相关。nNO 检测结果在指导初级保健机构转诊至耳鼻喉科方面的适用性还应进一步评估。 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Acta Oto-Laryngologica is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=193690066
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2025.2612599
    Languages:
      – Code: eng
        Text: English
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        StartPage: 478
    Subjects:
      – SubjectFull: Prevention of surgical complications
        Type: general
      – SubjectFull: Cochlear implants
        Type: general
      – SubjectFull: Foreign body reaction
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
        Type: general
      – SubjectFull: Hyperplasia
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Complications of prosthesis
        Type: general
      – SubjectFull: Sensorineural hearing loss
        Type: general
      – SubjectFull: Fisher exact test
        Type: general
      – SubjectFull: Tissue adhesions
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Mann Whitney U Test
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Biomedical materials
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Granulation tissue
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      – SubjectFull: Metaplastic ossification
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      – SubjectFull: Medical records
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      – SubjectFull: Acquisition of data
        Type: general
      – SubjectFull: Hearing
        Type: general
      – SubjectFull: Data analysis software
        Type: general
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      – TitleFull: Impact of primary cochlear implantation packing materials on reimplantation surgical difficulty and histopathological outcomes: a retrospective cohort study.
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            – D: 01
              M: 04
              Text: Apr2026
              Type: published
              Y: 2026
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