The Impact of Perceived Stress on Frailty in Patients With First‐Ever Ischemic Stroke: A Cross‐Sectional Study.

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Title: The Impact of Perceived Stress on Frailty in Patients With First‐Ever Ischemic Stroke: A Cross‐Sectional Study.
Authors: Wen, Xin (AUTHOR), Jiang, Qin (AUTHOR), Shi, Min (AUTHOR), Zhang, Meng (AUTHOR), Chen, Qinglin (AUTHOR), Yang, Yongping (AUTHOR), Yuan, Wanfang (AUTHOR), Sampaio, Francisco (AUTHOR)
Source: Perspectives in Psychiatric Care. 5/13/2026, Vol. 2026, p1-10. 10p.
Subjects: Risk assessment, Cross-sectional method, NIH Stroke Scale, Academic medical centers, Income, Research funding, T-test (Statistics), Frail elderly, Statistical sampling, Questionnaires, Multiple regression analysis, Fisher exact test, Disease prevalence, Family history (Medicine), Anxiety, Age distribution, Descriptive statistics, Chi-squared test, Odds ratio, Psychological stress, Ischemic stroke, Statistics, Stroke patients, Psychological tests, Barthel Index, Data analysis software, Psychosocial factors, Disease incidence, Nonparametric statistics, Disease complications
Geographic Terms: China
Abstract: Background: The onset of frailty is not only linked to physiological mechanisms but is also influenced by psychological factors. Patients experiencing a first‐ever ischemic stroke may face heightened psychological adjustment challenges, thereby increasing their risk of frailty. The influence of perceived stress as a psychological variable measuring individual stress responses remains unclear in this population. Objective: To investigate the prevalence of frailty among patients with first‐ever ischemic stroke, analyse the factors influencing frailty and explore the impact of perceived stress on frailty in these patients. Methods: A cross‐sectional study employing convenience sampling was conducted, selecting patients with ischemic stroke admitted to the Department of Neurology at the Second People's Hospital of Yibin between December 2024 and July 2025 as the study subjects. Collect patient‐related data, including the general information questionnaire, FRAIL scale, the Perceived Stress Scale, the Patient Health Questionnaire‐9 and the Generalised Anxiety Disorder‐7. Patients were categorised into frail and nonfrail groups based on the occurrence of frailty. Logistic regression analysis was used to identify independent risk factors for frailty in patients with first‐ever ischemic stroke. Results: The prevalence of frailty among patients with first‐ever ischemic stroke in this study was 36.1%. Logistic regression analysis revealed that age (OR = 1.039, p = 0.012), mRS score (OR = 1.632, p = 0.004) and perceived stress (OR = 1.072, p = 0.012) constituted risk factors for frailty in patients with first‐ever ischemic stroke. No family history of stroke (OR = 0.374, p = 0.004) and per capita monthly household income of 3001–5000 CNY (OR = 0.332, p = 0.015) were protective factors against frailty in patients with a first‐ever ischemic stroke. Neither the GAD‐7 nor the PHQ‐9 scores were statistically significant in the regression model (p > 0.05). Conclusions: The incidence of frailty is relatively high among patients experiencing a first‐ever ischemic stroke. Healthcare professionals should pay particular attention to elderly patients, those with low income, a family history of stroke or poor neurological function. Perceived stress may be incorporated into routine assessment systems to identify individuals experiencing high psychological stress at an early stage. Targeted psychological counselling and stress management interventions can then be implemented to reduce the risk of frailty onset and improve overall rehabilitation outcomes for patients. [ABSTRACT FROM AUTHOR]
Copyright of Perspectives in Psychiatric Care is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The Impact of Perceived Stress on Frailty in Patients With First‐Ever Ischemic Stroke: A Cross‐Sectional Study.
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  Data: <searchLink fieldCode="AR" term="%22Wen%2C+Xin%22">Wen, Xin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Qin%22">Jiang, Qin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Min%22">Shi, Min</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Meng%22">Zhang, Meng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Qinglin%22">Chen, Qinglin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Yongping%22">Yang, Yongping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Wanfang%22">Yuan, Wanfang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sampaio%2C+Francisco%22">Sampaio, Francisco</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Perspectives+in+Psychiatric+Care%22">Perspectives in Psychiatric Care</searchLink>. 5/13/2026, Vol. 2026, p1-10. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22NIH+Stroke+Scale%22">NIH Stroke Scale</searchLink><br /><searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br /><searchLink fieldCode="DE" term="%22Income%22">Income</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Frail+elderly%22">Frail elderly</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+sampling%22">Statistical sampling</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Fisher+exact+test%22">Fisher exact test</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+prevalence%22">Disease prevalence</searchLink><br /><searchLink fieldCode="DE" term="%22Family+history+%28Medicine%29%22">Family history (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Age+distribution%22">Age distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemic+stroke%22">Ischemic stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke+patients%22">Stroke patients</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+tests%22">Psychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Barthel+Index%22">Barthel Index</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Psychosocial+factors%22">Psychosocial factors</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+incidence%22">Disease incidence</searchLink><br /><searchLink fieldCode="DE" term="%22Nonparametric+statistics%22">Nonparametric statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
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  Data: Background: The onset of frailty is not only linked to physiological mechanisms but is also influenced by psychological factors. Patients experiencing a first‐ever ischemic stroke may face heightened psychological adjustment challenges, thereby increasing their risk of frailty. The influence of perceived stress as a psychological variable measuring individual stress responses remains unclear in this population. Objective: To investigate the prevalence of frailty among patients with first‐ever ischemic stroke, analyse the factors influencing frailty and explore the impact of perceived stress on frailty in these patients. Methods: A cross‐sectional study employing convenience sampling was conducted, selecting patients with ischemic stroke admitted to the Department of Neurology at the Second People's Hospital of Yibin between December 2024 and July 2025 as the study subjects. Collect patient‐related data, including the general information questionnaire, FRAIL scale, the Perceived Stress Scale, the Patient Health Questionnaire‐9 and the Generalised Anxiety Disorder‐7. Patients were categorised into frail and nonfrail groups based on the occurrence of frailty. Logistic regression analysis was used to identify independent risk factors for frailty in patients with first‐ever ischemic stroke. Results: The prevalence of frailty among patients with first‐ever ischemic stroke in this study was 36.1%. Logistic regression analysis revealed that age (OR = 1.039, p = 0.012), mRS score (OR = 1.632, p = 0.004) and perceived stress (OR = 1.072, p = 0.012) constituted risk factors for frailty in patients with first‐ever ischemic stroke. No family history of stroke (OR = 0.374, p = 0.004) and per capita monthly household income of 3001–5000 CNY (OR = 0.332, p = 0.015) were protective factors against frailty in patients with a first‐ever ischemic stroke. Neither the GAD‐7 nor the PHQ‐9 scores were statistically significant in the regression model (p > 0.05). Conclusions: The incidence of frailty is relatively high among patients experiencing a first‐ever ischemic stroke. Healthcare professionals should pay particular attention to elderly patients, those with low income, a family history of stroke or poor neurological function. Perceived stress may be incorporated into routine assessment systems to identify individuals experiencing high psychological stress at an early stage. Targeted psychological counselling and stress management interventions can then be implemented to reduce the risk of frailty onset and improve overall rehabilitation outcomes for patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Perspectives in Psychiatric Care is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1155/ppc/9031782
    Languages:
      – Code: eng
        Text: English
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      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: NIH Stroke Scale
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      – SubjectFull: Academic medical centers
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      – SubjectFull: Income
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      – SubjectFull: Research funding
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      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Frail elderly
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      – SubjectFull: Statistical sampling
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      – SubjectFull: Questionnaires
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      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Fisher exact test
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      – SubjectFull: Disease prevalence
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      – SubjectFull: Family history (Medicine)
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      – SubjectFull: Anxiety
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      – SubjectFull: Age distribution
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      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Odds ratio
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      – SubjectFull: Psychological stress
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      – SubjectFull: Ischemic stroke
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Stroke patients
        Type: general
      – SubjectFull: Psychological tests
        Type: general
      – SubjectFull: Barthel Index
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      – SubjectFull: Psychosocial factors
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      – SubjectFull: Disease incidence
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      – SubjectFull: Nonparametric statistics
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      – SubjectFull: Disease complications
        Type: general
      – SubjectFull: China
        Type: general
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      – TitleFull: The Impact of Perceived Stress on Frailty in Patients With First‐Ever Ischemic Stroke: A Cross‐Sectional Study.
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              Text: 5/13/2026
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