Effects of continuous bipolar hippocampal deep brain stimulation on memory in patients with unilateral or bilateral refractory temporal lobe epilepsy.
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| Title: | Effects of continuous bipolar hippocampal deep brain stimulation on memory in patients with unilateral or bilateral refractory temporal lobe epilepsy. |
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| Authors: | Ortiz, Fernanda Lacerda (AUTHOR), Cukiert, Cristine Mella (AUTHOR), Vieira, Julia Vescovi (AUTHOR), de Oliveira, João Paulo Santiago (AUTHOR), Burattini, Jose Augusto (AUTHOR), Guimaraes, Rafael Basilio (AUTHOR), Capitao, Pamela Spina (AUTHOR), Cukiert, Arthur (AUTHOR) |
| Source: | Epilepsia (Series 4). May2026, Vol. 67 Issue 5, p2171-2176. 6p. |
| Subjects: | Deep brain stimulation, Temporal lobe epilepsy, Cognitive ability, Prospective memory, Neuropsychological tests |
| Abstract: | Objective: To evaluate the long‐term cognitive and memory outcomes in patients with drug‐resistant temporal lobe epilepsy (TLE) treated with continuous hippocampal deep brain stimulation (Hip‐DBS), particularly in individuals not eligible for resective surgery. Methods: Nine patients (5 female; mean age 37 years) with drug‐resistant TLE underwent unilateral or bilateral Hip‐DBS via an occipital trajectory. Patients were selected based on bilateral independent seizure onsets, absence of resectable lesions, or high cognitive functioning. All patients underwent comprehensive pre‐ and post‐operative neuropsychological assessments, including the Wechsler Adult Intelligence Scale (WAIS)/Wechsler Intelligence Scale for Children (WISC), Developmental Neuropsychological Assessment (NEPSY), Wechsler Memory Scale, and Rey Auditory Verbal Learning Test (RAVLT). Follow‐up ranged from 24 to 121 months (mean: 68 months). Continuous bipolar stimulation was delivered using anterior hippocampal contacts as cathodes and posterior contacts as anodes. Results: All patients demonstrated significant seizure reduction; four were seizure‐free and five were responders (>80% reduction). No morbidity or mortality occurred. Cognitive outcomes remained stable across the cohort. No significant post‐operative decline was observed in full‐scale, verbal, or performance IQ or memory performance, regardless of unilateral or bilateral stimulation. One patient, with pre‐existing major depression, exhibited cognitive decline and reduced memory scores. However, this was attributed to psychiatric deterioration rather than stimulation effects. Her symptoms stabilized following psychiatric treatment, and DBS was reinitiated without further cognitive decline. Significance: This study provides long‐term evidence supporting the cognitive safety and efficacy of continuous Hip‐DBS in patients with refractory TLE. Both unilateral and bilateral stimulation were well tolerated, with preserved cognitive and memory function in high‐functioning individuals. The findings reinforce the value of Hip‐DBS as a non‐resective alternative for patients with bilateral or eloquent temporal seizure onsets. Comprehensive psychiatric evaluation and long‐term follow‐up are critical for optimizing outcomes. Larger, multicenter studies are needed to refine stimulation protocols and better characterize cognitive trajectories. [ABSTRACT FROM AUTHOR] |
| Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 193814281 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of continuous bipolar hippocampal deep brain stimulation on memory in patients with unilateral or bilateral refractory temporal lobe epilepsy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ortiz%2C+Fernanda+Lacerda%22">Ortiz, Fernanda Lacerda</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cukiert%2C+Cristine+Mella%22">Cukiert, Cristine Mella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vieira%2C+Julia+Vescovi%22">Vieira, Julia Vescovi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Oliveira%2C+João+Paulo+Santiago%22">de Oliveira, João Paulo Santiago</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burattini%2C+Jose+Augusto%22">Burattini, Jose Augusto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guimaraes%2C+Rafael+Basilio%22">Guimaraes, Rafael Basilio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Capitao%2C+Pamela+Spina%22">Capitao, Pamela Spina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cukiert%2C+Arthur%22">Cukiert, Arthur</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. May2026, Vol. 67 Issue 5, p2171-2176. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Deep+brain+stimulation%22">Deep brain stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+lobe+epilepsy%22">Temporal lobe epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Prospective+memory%22">Prospective memory</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: To evaluate the long‐term cognitive and memory outcomes in patients with drug‐resistant temporal lobe epilepsy (TLE) treated with continuous hippocampal deep brain stimulation (Hip‐DBS), particularly in individuals not eligible for resective surgery. Methods: Nine patients (5 female; mean age 37 years) with drug‐resistant TLE underwent unilateral or bilateral Hip‐DBS via an occipital trajectory. Patients were selected based on bilateral independent seizure onsets, absence of resectable lesions, or high cognitive functioning. All patients underwent comprehensive pre‐ and post‐operative neuropsychological assessments, including the Wechsler Adult Intelligence Scale (WAIS)/Wechsler Intelligence Scale for Children (WISC), Developmental Neuropsychological Assessment (NEPSY), Wechsler Memory Scale, and Rey Auditory Verbal Learning Test (RAVLT). Follow‐up ranged from 24 to 121 months (mean: 68 months). Continuous bipolar stimulation was delivered using anterior hippocampal contacts as cathodes and posterior contacts as anodes. Results: All patients demonstrated significant seizure reduction; four were seizure‐free and five were responders (>80% reduction). No morbidity or mortality occurred. Cognitive outcomes remained stable across the cohort. No significant post‐operative decline was observed in full‐scale, verbal, or performance IQ or memory performance, regardless of unilateral or bilateral stimulation. One patient, with pre‐existing major depression, exhibited cognitive decline and reduced memory scores. However, this was attributed to psychiatric deterioration rather than stimulation effects. Her symptoms stabilized following psychiatric treatment, and DBS was reinitiated without further cognitive decline. Significance: This study provides long‐term evidence supporting the cognitive safety and efficacy of continuous Hip‐DBS in patients with refractory TLE. Both unilateral and bilateral stimulation were well tolerated, with preserved cognitive and memory function in high‐functioning individuals. The findings reinforce the value of Hip‐DBS as a non‐resective alternative for patients with bilateral or eloquent temporal seizure onsets. Comprehensive psychiatric evaluation and long‐term follow‐up are critical for optimizing outcomes. Larger, multicenter studies are needed to refine stimulation protocols and better characterize cognitive trajectories. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/epi.70128 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 2171 Subjects: – SubjectFull: Deep brain stimulation Type: general – SubjectFull: Temporal lobe epilepsy Type: general – SubjectFull: Cognitive ability Type: general – SubjectFull: Prospective memory Type: general – SubjectFull: Neuropsychological tests Type: general Titles: – TitleFull: Effects of continuous bipolar hippocampal deep brain stimulation on memory in patients with unilateral or bilateral refractory temporal lobe epilepsy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ortiz, Fernanda Lacerda – PersonEntity: Name: NameFull: Cukiert, Cristine Mella – PersonEntity: Name: NameFull: Vieira, Julia Vescovi – PersonEntity: Name: NameFull: de Oliveira, João Paulo Santiago – PersonEntity: Name: NameFull: Burattini, Jose Augusto – PersonEntity: Name: NameFull: Guimaraes, Rafael Basilio – PersonEntity: Name: NameFull: Capitao, Pamela Spina – PersonEntity: Name: NameFull: Cukiert, Arthur IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00139580 Numbering: – Type: volume Value: 67 – Type: issue Value: 5 Titles: – TitleFull: Epilepsia (Series 4) Type: main |
| ResultId | 1 |
