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Neuroanatomical localization of faciobrachial dystonic seizures in LGI1‐antibody encephalitis.

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Title: Neuroanatomical localization of faciobrachial dystonic seizures in LGI1‐antibody encephalitis.
Authors: Ahn, Soo Hyun (AUTHOR), Karaminiya, Maryam (AUTHOR), Goh, Yihui (AUTHOR), Ha, Woo‐Seok (AUTHOR), Shin, Yoonhee (AUTHOR), Jang, Yoonhyuk (AUTHOR), Banks, Samantha (AUTHOR), Jung, Ki‐Young (AUTHOR), Chu, Kon (AUTHOR), Lee, Sang‐Kun (AUTHOR), Kim, Kyung Min (AUTHOR), Hong, Seung Bong (AUTHOR), Irani, Sarosh (AUTHOR), Lee, Soon‐Tae (AUTHOR)
Source: Epilepsia (Series 4). May2026, Vol. 67 Issue 5, pe67-e71. 5p.
Subjects: Autoimmune encephalitis, Seizures (Medicine), Electroencephalography, Somatosensory cortex, Motor cortex, Brain function localization, Insular cortex, Magnetoencephalography
Abstract: Faciobrachial dystonic seizures (FBDS), paroxysmal dizziness spells, and thermal sensory attacks are highly frequent and stereotypic phenomena experienced in leucine‐rich glioma inactivated 1 (LGI1)‐antibody encephalitis. This study aims to describe the electrophysiologic mechanism underlying these pathognomonic symptoms. LGI1‐antibody encephalitis patients with active symptoms were enrolled from two separate centers in South Korea and the United States. Patients were evaluated with simultaneous magnetoencephalography (306 channels) and electroencephalography. Regional alterations in neuronal excitability represented by interictal epileptiform discharges were present in the faciobrachial area of the motor cortex, insula, and somatosensory cortex, somatotopically aligned with each of the ictal semiologies observed in patients. FBDS and other LGI1‐antibody encephalitis‐specific spells localized to cortical regions neuroanatomically corresponding to ictal semiologies: the faciobrachial homunculus (FBDS), insular cortex (paroxysmal dizziness spells), and somatosensory cortex (thermal sensory attacks). Our findings support the ictal hypothesis underlying these unique phenomena. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubTypeId: academicJournal
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  Data: Neuroanatomical localization of faciobrachial dystonic seizures in LGI1‐antibody encephalitis.
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  Data: <searchLink fieldCode="AR" term="%22Ahn%2C+Soo+Hyun%22">Ahn, Soo Hyun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Karaminiya%2C+Maryam%22">Karaminiya, Maryam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goh%2C+Yihui%22">Goh, Yihui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ha%2C+Woo‐Seok%22">Ha, Woo‐Seok</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shin%2C+Yoonhee%22">Shin, Yoonhee</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jang%2C+Yoonhyuk%22">Jang, Yoonhyuk</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Banks%2C+Samantha%22">Banks, Samantha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jung%2C+Ki‐Young%22">Jung, Ki‐Young</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chu%2C+Kon%22">Chu, Kon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Sang‐Kun%22">Lee, Sang‐Kun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Kyung+Min%22">Kim, Kyung Min</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hong%2C+Seung+Bong%22">Hong, Seung Bong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Irani%2C+Sarosh%22">Irani, Sarosh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Soon‐Tae%22">Lee, Soon‐Tae</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. May2026, Vol. 67 Issue 5, pe67-e71. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Autoimmune+encephalitis%22">Autoimmune encephalitis</searchLink><br /><searchLink fieldCode="DE" term="%22Seizures+%28Medicine%29%22">Seizures (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Electroencephalography%22">Electroencephalography</searchLink><br /><searchLink fieldCode="DE" term="%22Somatosensory+cortex%22">Somatosensory cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+cortex%22">Motor cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+function+localization%22">Brain function localization</searchLink><br /><searchLink fieldCode="DE" term="%22Insular+cortex%22">Insular cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetoencephalography%22">Magnetoencephalography</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Faciobrachial dystonic seizures (FBDS), paroxysmal dizziness spells, and thermal sensory attacks are highly frequent and stereotypic phenomena experienced in leucine‐rich glioma inactivated 1 (LGI1)‐antibody encephalitis. This study aims to describe the electrophysiologic mechanism underlying these pathognomonic symptoms. LGI1‐antibody encephalitis patients with active symptoms were enrolled from two separate centers in South Korea and the United States. Patients were evaluated with simultaneous magnetoencephalography (306 channels) and electroencephalography. Regional alterations in neuronal excitability represented by interictal epileptiform discharges were present in the faciobrachial area of the motor cortex, insula, and somatosensory cortex, somatotopically aligned with each of the ictal semiologies observed in patients. FBDS and other LGI1‐antibody encephalitis‐specific spells localized to cortical regions neuroanatomically corresponding to ictal semiologies: the faciobrachial homunculus (FBDS), insular cortex (paroxysmal dizziness spells), and somatosensory cortex (thermal sensory attacks). Our findings support the ictal hypothesis underlying these unique phenomena. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=193814303
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      – Type: doi
        Value: 10.1002/epi.70197
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: e67
    Subjects:
      – SubjectFull: Autoimmune encephalitis
        Type: general
      – SubjectFull: Seizures (Medicine)
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      – SubjectFull: Electroencephalography
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      – SubjectFull: Somatosensory cortex
        Type: general
      – SubjectFull: Motor cortex
        Type: general
      – SubjectFull: Brain function localization
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      – SubjectFull: Insular cortex
        Type: general
      – SubjectFull: Magnetoencephalography
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    Titles:
      – TitleFull: Neuroanatomical localization of faciobrachial dystonic seizures in LGI1‐antibody encephalitis.
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              M: 05
              Text: May2026
              Type: published
              Y: 2026
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