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Performance of the 5‐SENSE score in a pediatric and young adult cohort of 100 consecutive stereoelectroencephalography cases.

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Title: Performance of the 5‐SENSE score in a pediatric and young adult cohort of 100 consecutive stereoelectroencephalography cases.
Authors: Trank, Lindsey (AUTHOR), Weber, Amanda R. B. (AUTHOR), Beatty, Christopher (AUTHOR), Brown‐Mitchell, Gabrielle (AUTHOR), Eisner, Mariah (AUTHOR), Pindrik, Jonathan (AUTHOR), Shaikhouni, Ammar (AUTHOR), Ostendorf, Adam (AUTHOR)
Source: Epilepsia (Series 4). May2026, Vol. 67 Issue 5, pe54-e59. 6p.
Subjects: Sensitivity & specificity (Statistics), Electroencephalography, Treatment effectiveness, Diagnosis, Partial epilepsy, Childhood epilepsy
Abstract: This study assesses the validity of the 5‐SENSE score in a cohort of pediatric patients with epilepsy and evaluates associations between the score, ancillary testing, and surgical outcomes. We retrospectively calculated the 5‐SENSE score in a single‐center predominantly pediatric cohort and calculated the sensitivity and specificity for predicting a non‐focal stereo‐electroencephalography (SEEG). In addition, we examined the relationship between score and post‐surgical outcome. Finally, we evaluated the association between ancillary testing and SEEG focality. One hundred cases were included. The 5‐SENSE score had a sensitivity (95% confidence interval [CI]) of 49% (35.6–62.2), specificity of 75% (63.6–85.5), and area under the curve of 0.673 (0.567–0.780). The sensitivity and specificity were similar in children 13 years or younger compared to those older than 13 years. Ancillary testing lateralized in agreement with a focal SEEG finding in 61% of patients, with sensitivity of 43% and specificity of 76% (p = 0.045). Ancillary testing confirmed the 5‐SENSE score but did not significantly improve sensitivity. Higher 5‐SENSE scores were associated with better Engel outcomes (p = 0.037). The 5‐SENSE score performed comparably to the published adult validation cohort. Use of the 5‐SENSE score in pediatric patients may improve patient selection for SEEG but is not a sole predictor of result or outcome. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Performance of the 5‐SENSE score in a pediatric and young adult cohort of 100 consecutive stereoelectroencephalography cases.
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  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. May2026, Vol. 67 Issue 5, pe54-e59. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Sensitivity+%26+specificity+%28Statistics%29%22">Sensitivity & specificity (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Electroencephalography%22">Electroencephalography</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Partial+epilepsy%22">Partial epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Childhood+epilepsy%22">Childhood epilepsy</searchLink>
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  Data: This study assesses the validity of the 5‐SENSE score in a cohort of pediatric patients with epilepsy and evaluates associations between the score, ancillary testing, and surgical outcomes. We retrospectively calculated the 5‐SENSE score in a single‐center predominantly pediatric cohort and calculated the sensitivity and specificity for predicting a non‐focal stereo‐electroencephalography (SEEG). In addition, we examined the relationship between score and post‐surgical outcome. Finally, we evaluated the association between ancillary testing and SEEG focality. One hundred cases were included. The 5‐SENSE score had a sensitivity (95% confidence interval [CI]) of 49% (35.6–62.2), specificity of 75% (63.6–85.5), and area under the curve of 0.673 (0.567–0.780). The sensitivity and specificity were similar in children 13 years or younger compared to those older than 13 years. Ancillary testing lateralized in agreement with a focal SEEG finding in 61% of patients, with sensitivity of 43% and specificity of 76% (p = 0.045). Ancillary testing confirmed the 5‐SENSE score but did not significantly improve sensitivity. Higher 5‐SENSE scores were associated with better Engel outcomes (p = 0.037). The 5‐SENSE score performed comparably to the published adult validation cohort. Use of the 5‐SENSE score in pediatric patients may improve patient selection for SEEG but is not a sole predictor of result or outcome. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=193814307
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        Value: 10.1002/epi.70214
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        Text: English
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      – SubjectFull: Electroencephalography
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Partial epilepsy
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      – SubjectFull: Childhood epilepsy
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      – TitleFull: Performance of the 5‐SENSE score in a pediatric and young adult cohort of 100 consecutive stereoelectroencephalography cases.
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              M: 05
              Text: May2026
              Type: published
              Y: 2026
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