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Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease.

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Title: Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease.
Authors: Martínez‐Tazo, Patricia (AUTHOR), Mejias‐Ortega, Marina (AUTHOR), López‐López, Verónica (AUTHOR), Bhojwani‐Cabrera, Aysha M. (AUTHOR), Saxton, Emma (AUTHOR), Canals, Santiago (AUTHOR), Hardingham, Giles (AUTHOR), Gutierrez, Antonia (AUTHOR), Lopez‐Atalaya, Jose P. (AUTHOR), De Santis, Silvia (AUTHOR)
Source: European Journal of Neuroscience. May2026, Vol. 63 Issue 9, p1-13. 13p.
Subjects: Microglia, Alzheimer's disease, Cytology, Molecular biology, Multiscale modeling, Neuroinflammation, Imaging systems, Genetics
Abstract: Microglia, the resident innate immune cells of the central nervous system, play a pivotal role in the pathogenesis of Alzheimer's disease (AD). Microglia are now recognized as a highly dynamic and heterogeneous population whose molecular and functional states vary with spatial context, disease stage, and genetic background. Recent discoveries across multiple scales from genetics, molecular and cellular biology, to systems‐level imaging and epidemiology have underscored the complex and context‐dependent contributions of microglia to the AD cascade. Together, these findings highlight the need for integrative, multiscale approaches that bridge molecular, cellular, and systemic perspectives to elucidate the diverse roles of microglia and their impact on disease progression. This mini‐review discusses recent advances in understanding microglial biology across these dimensions and outlines current challenges toward achieving a more unified and therapeutically oriented framework for studying microglia in AD. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease.
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  Data: <searchLink fieldCode="AR" term="%22Martínez‐Tazo%2C+Patricia%22">Martínez‐Tazo, Patricia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mejias‐Ortega%2C+Marina%22">Mejias‐Ortega, Marina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22López‐López%2C+Verónica%22">López‐López, Verónica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bhojwani‐Cabrera%2C+Aysha+M%2E%22">Bhojwani‐Cabrera, Aysha M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saxton%2C+Emma%22">Saxton, Emma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Canals%2C+Santiago%22">Canals, Santiago</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hardingham%2C+Giles%22">Hardingham, Giles</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gutierrez%2C+Antonia%22">Gutierrez, Antonia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lopez‐Atalaya%2C+Jose+P%2E%22">Lopez‐Atalaya, Jose P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Santis%2C+Silvia%22">De Santis, Silvia</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. May2026, Vol. 63 Issue 9, p1-13. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Microglia%22">Microglia</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Cytology%22">Cytology</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+biology%22">Molecular biology</searchLink><br /><searchLink fieldCode="DE" term="%22Multiscale+modeling%22">Multiscale modeling</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroinflammation%22">Neuroinflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Imaging+systems%22">Imaging systems</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink>
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  Data: Microglia, the resident innate immune cells of the central nervous system, play a pivotal role in the pathogenesis of Alzheimer's disease (AD). Microglia are now recognized as a highly dynamic and heterogeneous population whose molecular and functional states vary with spatial context, disease stage, and genetic background. Recent discoveries across multiple scales from genetics, molecular and cellular biology, to systems‐level imaging and epidemiology have underscored the complex and context‐dependent contributions of microglia to the AD cascade. Together, these findings highlight the need for integrative, multiscale approaches that bridge molecular, cellular, and systemic perspectives to elucidate the diverse roles of microglia and their impact on disease progression. This mini‐review discusses recent advances in understanding microglial biology across these dimensions and outlines current challenges toward achieving a more unified and therapeutically oriented framework for studying microglia in AD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=193814613
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        Value: 10.1111/ejn.70536
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        Text: English
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      – SubjectFull: Microglia
        Type: general
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      – SubjectFull: Cytology
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      – SubjectFull: Molecular biology
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      – SubjectFull: Multiscale modeling
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      – SubjectFull: Imaging systems
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      – TitleFull: Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease.
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              Text: May2026
              Type: published
              Y: 2026
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