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Frequency‐Tagging Captures Distinct Neural Responses Elicited by Bilateral Periodic Thermonociceptive Stimulation.

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Title: Frequency‐Tagging Captures Distinct Neural Responses Elicited by Bilateral Periodic Thermonociceptive Stimulation.
Authors: Leu, Chiara (AUTHOR), Herbillon, Gabrielle (AUTHOR), Liberati, Giulia (AUTHOR), Legrain, Valéry (AUTHOR)
Source: European Journal of Neuroscience. May2026, Vol. 63 Issue 9, p1-11. 11p.
Subjects: Intermodulation, Sensory stimulation, Nociceptors, Evoked potentials (Electrophysiology), Sensorimotor integration
Abstract: Sustained periodic stimuli are known to elicit a periodic neural response (i.e., steady‐state evoked potential) in the EEG frequency spectrum. These responses can easily be traced at their frequency of stimulation and corresponding harmonics using a frequency‐tagging approach. To date, sustained periodic thermonociceptive stimuli have only been used on one extremity (e.g., right volar forearm) at a time. Extending this procedure to sustained stimulation applied concomitantly to distinct limbs would allow us to study the mechanisms of integration or competition between sensory signals from these different body locations. This study demonstrates that slow, sustained, sinusoidal thermonociceptive stimuli, bilaterally applied using two different stimulation frequencies (i.e., f1, f2, one on each forearm), elicit two distinct neural periodic responses at the respective frequency of stimulation and their harmonics. Additionally, we showed preliminary evidence for an interaction between the neural populations involved in the response to these stimuli, marked by neural activity at intermodulation frequencies (n* f1 ± m* f2). While encouraging, further studies designed specifically to tease out these intermodulation responses are needed to corroborate our findings. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Frequency‐Tagging Captures Distinct Neural Responses Elicited by Bilateral Periodic Thermonociceptive Stimulation.
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  Data: <searchLink fieldCode="AR" term="%22Leu%2C+Chiara%22">Leu, Chiara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Herbillon%2C+Gabrielle%22">Herbillon, Gabrielle</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liberati%2C+Giulia%22">Liberati, Giulia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Legrain%2C+Valéry%22">Legrain, Valéry</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. May2026, Vol. 63 Issue 9, p1-11. 11p.
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– Name: Abstract
  Label: Abstract
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  Data: Sustained periodic stimuli are known to elicit a periodic neural response (i.e., steady‐state evoked potential) in the EEG frequency spectrum. These responses can easily be traced at their frequency of stimulation and corresponding harmonics using a frequency‐tagging approach. To date, sustained periodic thermonociceptive stimuli have only been used on one extremity (e.g., right volar forearm) at a time. Extending this procedure to sustained stimulation applied concomitantly to distinct limbs would allow us to study the mechanisms of integration or competition between sensory signals from these different body locations. This study demonstrates that slow, sustained, sinusoidal thermonociceptive stimuli, bilaterally applied using two different stimulation frequencies (i.e., f1, f2, one on each forearm), elicit two distinct neural periodic responses at the respective frequency of stimulation and their harmonics. Additionally, we showed preliminary evidence for an interaction between the neural populations involved in the response to these stimuli, marked by neural activity at intermodulation frequencies (n* f1 ± m* f2). While encouraging, further studies designed specifically to tease out these intermodulation responses are needed to corroborate our findings. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=193814616
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      – Type: doi
        Value: 10.1111/ejn.70539
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Sensory stimulation
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      – SubjectFull: Nociceptors
        Type: general
      – SubjectFull: Evoked potentials (Electrophysiology)
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      – SubjectFull: Sensorimotor integration
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      – TitleFull: Frequency‐Tagging Captures Distinct Neural Responses Elicited by Bilateral Periodic Thermonociceptive Stimulation.
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            NameFull: Leu, Chiara
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            NameFull: Herbillon, Gabrielle
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            NameFull: Liberati, Giulia
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            NameFull: Legrain, Valéry
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            – D: 01
              M: 05
              Text: May2026
              Type: published
              Y: 2026
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            – TitleFull: European Journal of Neuroscience
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