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Validation of the ND-PAE Diagnosis in Children with Heavy Prenatal Alcohol Exposure.

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Title: Validation of the ND-PAE Diagnosis in Children with Heavy Prenatal Alcohol Exposure.
Authors: Veziris, Christina R. (AUTHOR), Hyland, Matthew T. (AUTHOR), Kable, Julie A. (AUTHOR), Wozniak, Jeffrey R. (AUTHOR), Coles, Claire D. (AUTHOR), May, Philip A. (AUTHOR), Kalberg, Wendy O. (AUTHOR), Sowell, Elizabeth R. (AUTHOR), Jones, Kenneth L. (AUTHOR), Riley, Edward P. (AUTHOR), Mattson, Sarah N. (AUTHOR)
Source: Child Psychiatry & Human Development. Jun2026, Vol. 57 Issue 3, p731-745. 15p.
Subjects: Prenatal alcohol exposure, Neurobehavioral disorders, Fetal alcohol syndrome, Neuropsychological tests, Activities of daily living, Pediatric neurology
Abstract: This study evaluated criteria for neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE). Kable et al. (Child Psychiatry Hum Dev 55:426, 2022) assessed the validity of this diagnosis in a sample with low exposure to alcohol. The current study expanded this assessment to a sample with a wider age range and heavier alcohol exposure. Data were collected from participants (5–17 years) with prenatal alcohol exposure (PAE) and typically developing controls at six Collaborative Initiative on Fetal Alcohol Spectrum Disorders sites using neuropsychological assessment and caregiver reports. Impairment was tested at 1SD, 1.5SD, and 2SD below the normative average and a modification of the adaptive functioning requirement was tested. Testing impairment at 1SD resulted in the highest endorsement rates in both groups. Our findings replicated the study by Kable et al. and show that current criteria captured a high rate of those with PAE and that requiring fewer adaptive functioning criteria resulted in higher sensitivity to PAE. [ABSTRACT FROM AUTHOR]
Copyright of Child Psychiatry & Human Development is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Validation of the ND-PAE Diagnosis in Children with Heavy Prenatal Alcohol Exposure.
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  Data: <searchLink fieldCode="AR" term="%22Veziris%2C+Christina+R%2E%22">Veziris, Christina R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hyland%2C+Matthew+T%2E%22">Hyland, Matthew T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kable%2C+Julie+A%2E%22">Kable, Julie A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wozniak%2C+Jeffrey+R%2E%22">Wozniak, Jeffrey R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coles%2C+Claire+D%2E%22">Coles, Claire D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22May%2C+Philip+A%2E%22">May, Philip A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kalberg%2C+Wendy+O%2E%22">Kalberg, Wendy O.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sowell%2C+Elizabeth+R%2E%22">Sowell, Elizabeth R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jones%2C+Kenneth+L%2E%22">Jones, Kenneth L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riley%2C+Edward+P%2E%22">Riley, Edward P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mattson%2C+Sarah+N%2E%22">Mattson, Sarah N.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Child+Psychiatry+%26+Human+Development%22">Child Psychiatry & Human Development</searchLink>. Jun2026, Vol. 57 Issue 3, p731-745. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Prenatal+alcohol+exposure%22">Prenatal alcohol exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Neurobehavioral+disorders%22">Neurobehavioral disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Fetal+alcohol+syndrome%22">Fetal alcohol syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Activities+of+daily+living%22">Activities of daily living</searchLink><br /><searchLink fieldCode="DE" term="%22Pediatric+neurology%22">Pediatric neurology</searchLink>
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  Data: This study evaluated criteria for neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE). Kable et al. (Child Psychiatry Hum Dev 55:426, 2022) assessed the validity of this diagnosis in a sample with low exposure to alcohol. The current study expanded this assessment to a sample with a wider age range and heavier alcohol exposure. Data were collected from participants (5–17 years) with prenatal alcohol exposure (PAE) and typically developing controls at six Collaborative Initiative on Fetal Alcohol Spectrum Disorders sites using neuropsychological assessment and caregiver reports. Impairment was tested at 1SD, 1.5SD, and 2SD below the normative average and a modification of the adaptive functioning requirement was tested. Testing impairment at 1SD resulted in the highest endorsement rates in both groups. Our findings replicated the study by Kable et al. and show that current criteria captured a high rate of those with PAE and that requiring fewer adaptive functioning criteria resulted in higher sensitivity to PAE. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Child Psychiatry & Human Development is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jun2026
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