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Research progress of biomaterial conduit in repairing facial nerve injury.

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Title: Research progress of biomaterial conduit in repairing facial nerve injury.
Authors: Li, Yunuo (AUTHOR), Gao, Li (AUTHOR), Xie, Miao (AUTHOR), Yang, Rui (AUTHOR), Duan, Maoli (AUTHOR), Lu, Ling (AUTHOR)
Source: Acta Oto-Laryngologica. Jun2026, Vol. 146 Issue 6, p691-697. 7p.
Subjects: Hematopoietic stem cell transplantation, Nanostructures, Vascular endothelial growth factors, Autografts, Tissue engineering, Mesenchymal stem cells, Cell motility, Immune system, Biomedical materials, Facial nerve diseases, Facial nerve, Nervous system regeneration, Growth factors, Electric stimulation, Biodegradable materials, Three-dimensional printing, Pathologic neovascularization, Cell differentiation, Nerve growth factor
Abstract (English): Background: Facial nerve injury poses a major challenge in otolaryngology, where functional restoration remains critical. As autologous nerve grafts present limitations, biomaterial-based nerve guidance conduits (NGCs) offer a viable alternative for bridging nerve defects. Objective: This review covers the updated research results in NGCs in the past five years. Material and methods: Recent publications were critically reviewed. Results: This review highlights recent progress in advanced biomaterials and manufacturing methods for NGC fabrication, with emphasis on functionalization strategies—such as incorporation of stem cells, bioactive factors, topographic cues, and electrical stimulation—to synergistically enhance axonal regrowth, myelination, and functional recovery. Overall, biomaterial conduits are advancing as multifunctional integrated systems, showing strong translational potential for precision repair of facial nerves. Conclusion and significance: Over the past five years, research emphasis in this field has shifted toward developing composite conduit materials capable of actively guiding neural regeneration through the incorporation of biochemical and biological cues. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 面神经损伤是耳鼻喉科面临的一项重大挑战, 因为功能重建至关重要。由于自体神经移植存在局限性, 基于生物材料的神经导管(NGC)为修复神经缺损提供了一种可行的替代方案。 本综述涵盖了近五年来关于NGC的最新研究成果。 对近期发表的文献进行了批判性回顾。 本综述重点介绍了用于NGC制备的先进生物材料和制造方法的最新进展, 尤其强调了功能化策略, 例如整合干细胞、生物活性因子、拓扑结构和电刺激, 以协同增强轴突再生、髓鞘形成和功能恢复。总体而言, 生物材料导管正作为多功能集成系统不断发展, 展现出在面神经精准修复方面的巨大转化潜力。 过去五年, 该领域的研究重点已转向开发能够通过整合生物化学和生物信号主动引导神经再生的复合导管材料。 [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Research progress of biomaterial conduit in repairing facial nerve injury.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Li%2C+Yunuo%22">Li, Yunuo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gao%2C+Li%22">Gao, Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xie%2C+Miao%22">Xie, Miao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Rui%22">Yang, Rui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duan%2C+Maoli%22">Duan, Maoli</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Ling%22">Lu, Ling</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Jun2026, Vol. 146 Issue 6, p691-697. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Hematopoietic+stem+cell+transplantation%22">Hematopoietic stem cell transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Nanostructures%22">Nanostructures</searchLink><br /><searchLink fieldCode="DE" term="%22Vascular+endothelial+growth+factors%22">Vascular endothelial growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22Autografts%22">Autografts</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Mesenchymal+stem+cells%22">Mesenchymal stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+motility%22">Cell motility</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+system%22">Immune system</searchLink><br /><searchLink fieldCode="DE" term="%22Biomedical+materials%22">Biomedical materials</searchLink><br /><searchLink fieldCode="DE" term="%22Facial+nerve+diseases%22">Facial nerve diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Facial+nerve%22">Facial nerve</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system+regeneration%22">Nervous system regeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Growth+factors%22">Growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+stimulation%22">Electric stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Biodegradable+materials%22">Biodegradable materials</searchLink><br /><searchLink fieldCode="DE" term="%22Three-dimensional+printing%22">Three-dimensional printing</searchLink><br /><searchLink fieldCode="DE" term="%22Pathologic+neovascularization%22">Pathologic neovascularization</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+differentiation%22">Cell differentiation</searchLink><br /><searchLink fieldCode="DE" term="%22Nerve+growth+factor%22">Nerve growth factor</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Background: Facial nerve injury poses a major challenge in otolaryngology, where functional restoration remains critical. As autologous nerve grafts present limitations, biomaterial-based nerve guidance conduits (NGCs) offer a viable alternative for bridging nerve defects. Objective: This review covers the updated research results in NGCs in the past five years. Material and methods: Recent publications were critically reviewed. Results: This review highlights recent progress in advanced biomaterials and manufacturing methods for NGC fabrication, with emphasis on functionalization strategies—such as incorporation of stem cells, bioactive factors, topographic cues, and electrical stimulation—to synergistically enhance axonal regrowth, myelination, and functional recovery. Overall, biomaterial conduits are advancing as multifunctional integrated systems, showing strong translational potential for precision repair of facial nerves. Conclusion and significance: Over the past five years, research emphasis in this field has shifted toward developing composite conduit materials capable of actively guiding neural regeneration through the incorporation of biochemical and biological cues. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Chinese)
  Group: Ab
  Data: 面神经损伤是耳鼻喉科面临的一项重大挑战, 因为功能重建至关重要。由于自体神经移植存在局限性, 基于生物材料的神经导管(NGC)为修复神经缺损提供了一种可行的替代方案。 本综述涵盖了近五年来关于NGC的最新研究成果。 对近期发表的文献进行了批判性回顾。 本综述重点介绍了用于NGC制备的先进生物材料和制造方法的最新进展, 尤其强调了功能化策略, 例如整合干细胞、生物活性因子、拓扑结构和电刺激, 以协同增强轴突再生、髓鞘形成和功能恢复。总体而言, 生物材料导管正作为多功能集成系统不断发展, 展现出在面神经精准修复方面的巨大转化潜力。 过去五年, 该领域的研究重点已转向开发能够通过整合生物化学和生物信号主动引导神经再生的复合导管材料。 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2026.2627633
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 691
    Subjects:
      – SubjectFull: Hematopoietic stem cell transplantation
        Type: general
      – SubjectFull: Nanostructures
        Type: general
      – SubjectFull: Vascular endothelial growth factors
        Type: general
      – SubjectFull: Autografts
        Type: general
      – SubjectFull: Tissue engineering
        Type: general
      – SubjectFull: Mesenchymal stem cells
        Type: general
      – SubjectFull: Cell motility
        Type: general
      – SubjectFull: Immune system
        Type: general
      – SubjectFull: Biomedical materials
        Type: general
      – SubjectFull: Facial nerve diseases
        Type: general
      – SubjectFull: Facial nerve
        Type: general
      – SubjectFull: Nervous system regeneration
        Type: general
      – SubjectFull: Growth factors
        Type: general
      – SubjectFull: Electric stimulation
        Type: general
      – SubjectFull: Biodegradable materials
        Type: general
      – SubjectFull: Three-dimensional printing
        Type: general
      – SubjectFull: Pathologic neovascularization
        Type: general
      – SubjectFull: Cell differentiation
        Type: general
      – SubjectFull: Nerve growth factor
        Type: general
    Titles:
      – TitleFull: Research progress of biomaterial conduit in repairing facial nerve injury.
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            NameFull: Li, Yunuo
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            NameFull: Gao, Li
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            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
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