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Evaluating the heterogeneous treatment effects of major depression polygenic risk scores on self-harm using causal forest.

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Title: Evaluating the heterogeneous treatment effects of major depression polygenic risk scores on self-harm using causal forest.
Authors: Jeong, Eunji (AUTHOR), Lee, Chanhui (AUTHOR), Kim, Hyejin (AUTHOR), Yu, Hyeona (AUTHOR), Lee, Jakyung (AUTHOR), Ha, Tae Hyon (AUTHOR), Won, Hong-Hee (AUTHOR), Myung, Woojae (AUTHOR), Kang, Hyo Shin (AUTHOR), Park, Jungkyu (AUTHOR)
Source: Journal of Mental Health. Jun2026, Vol. 35 Issue 3, p330-343. 14p.
Subjects: Self-injurious behavior, T-test (Statistics), Research funding, Europeans, Social factors, Treatment effectiveness, Genetic risk score, Uk Biobank Ltd., Causality (Physics), Data analysis software, Mental depression
Abstract: Background: Self-harm, defined as non-fatal self-inflicted harm regardless of suicidal intent, is a critical global health issue influenced by the interaction between genetic and environmental factors. Aims: This study investigates the causal effect of major depression polygenic risk scores (MD PRS) on self-harm in individuals of European ancestry and explores how environmental and personal factors moderate this effect. Methods: Using data from 91,778 UK Biobank participants, we compared the top 10% with the highest MD PRS (the genetically vulnerable group) against the remainder. The causal relationship was examined using a causal forest approach to estimate average and heterogeneous treatment effects across non-genetic contributors. Results: Higher MD PRS was associated with an increased risk of self-harm. Significant heterogeneity was observed: the association was stronger among individuals exposed to physical violence or partner belittlement, but weaker among older adults and those with higher income. Conclusions: These findings highlight the importance of personalized prevention. Genetic vulnerability to depression reflects a heightened sensitivity to adverse environments, suggesting that genetic risk should be considered alongside trauma and socioeconomic contexts. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Mental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 194088910
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: Evaluating the heterogeneous treatment effects of major depression polygenic risk scores on self-harm using causal forest.
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  Data: <searchLink fieldCode="AR" term="%22Jeong%2C+Eunji%22">Jeong, Eunji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Chanhui%22">Lee, Chanhui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Hyejin%22">Kim, Hyejin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu%2C+Hyeona%22">Yu, Hyeona</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jakyung%22">Lee, Jakyung</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ha%2C+Tae+Hyon%22">Ha, Tae Hyon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Won%2C+Hong-Hee%22">Won, Hong-Hee</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Myung%2C+Woojae%22">Myung, Woojae</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kang%2C+Hyo+Shin%22">Kang, Hyo Shin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Jungkyu%22">Park, Jungkyu</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Mental+Health%22">Journal of Mental Health</searchLink>. Jun2026, Vol. 35 Issue 3, p330-343. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Self-injurious+behavior%22">Self-injurious behavior</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Europeans%22">Europeans</searchLink><br /><searchLink fieldCode="DE" term="%22Social+factors%22">Social factors</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+risk+score%22">Genetic risk score</searchLink><br /><searchLink fieldCode="DE" term="%22Uk+Biobank+Ltd%2E%22">Uk Biobank Ltd.</searchLink><br /><searchLink fieldCode="DE" term="%22Causality+%28Physics%29%22">Causality (Physics)</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Self-harm, defined as non-fatal self-inflicted harm regardless of suicidal intent, is a critical global health issue influenced by the interaction between genetic and environmental factors. Aims: This study investigates the causal effect of major depression polygenic risk scores (MD PRS) on self-harm in individuals of European ancestry and explores how environmental and personal factors moderate this effect. Methods: Using data from 91,778 UK Biobank participants, we compared the top 10% with the highest MD PRS (the genetically vulnerable group) against the remainder. The causal relationship was examined using a causal forest approach to estimate average and heterogeneous treatment effects across non-genetic contributors. Results: Higher MD PRS was associated with an increased risk of self-harm. Significant heterogeneity was observed: the association was stronger among individuals exposed to physical violence or partner belittlement, but weaker among older adults and those with higher income. Conclusions: These findings highlight the importance of personalized prevention. Genetic vulnerability to depression reflects a heightened sensitivity to adverse environments, suggesting that genetic risk should be considered alongside trauma and socioeconomic contexts. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Mental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=194088910
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/09638237.2026.2645539
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 14
        StartPage: 330
    Subjects:
      – SubjectFull: Self-injurious behavior
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Europeans
        Type: general
      – SubjectFull: Social factors
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Genetic risk score
        Type: general
      – SubjectFull: Uk Biobank Ltd.
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      – SubjectFull: Causality (Physics)
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      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Mental depression
        Type: general
    Titles:
      – TitleFull: Evaluating the heterogeneous treatment effects of major depression polygenic risk scores on self-harm using causal forest.
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            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
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