View in EDS

Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine (DMT).

Saved in:
Bibliographic Details
Title: Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine (DMT).
Authors: Lewis-Healey, Evan (AUTHOR), Pallavicini, Carla (AUTHOR), Cavanna, Federico (AUTHOR), D'Amelio, Tomas (AUTHOR), De La Fuente, Laura Alethia (AUTHOR), Copa, Debora (AUTHOR), Müller, Stephanie (AUTHOR), Bruno, Nicolas (AUTHOR), Tagliazucchi, Enzo (AUTHOR), Bekinschtein, Tristan (AUTHOR)
Source: Journal of Cognitive Neuroscience. Jun2026, Vol. 38 Issue 6, p1244-1263. 20p.
Subjects: Dimethyltryptamine, Electroencephalography, Hallucinogenic drugs, Hallucinations, Neurophysiology, Consciousness
Abstract: N,N-dimethyltryptamine (DMT) is a fast-acting psychedelic drug that induces a radical reorganization of conscious contents and brain dynamics. However, our understanding of how brain dynamics support psychedelic-induced conscious states remains unclear. We therefore present a repeated-measures dose-dependent study of the subjective and neural dynamics induced through DMT under naturalistic conditions. Nineteen participants received either a 20-mg or a 40-mg dose of freebase DMT across two sessions in a blinded, counterbalanced order. Electroencephalography data and time-resolved measures of subjective experience (Temporal Experience Tracing) were collected. Both doses of DMT induced rapid changes in experience dimensions, with the 40-mg dose inducing more extreme visual hallucinations and emotionally intense experiences. A variety of neural features were computed on the electroencephalography data, with oscillatory alpha power and permutation entropy most strongly associated with continuous subjective experience dimensions. Strikingly, Lempel–Ziv complexity, previously hailed as a robust correlate of subjective experiences within the psychedelic state, yielded the weakest associations. These findings suggest that the relationship between neural complexity and phenomenology in psychedelic states is less clear than originally hypothesized. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 194131763
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine (DMT).
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Lewis-Healey%2C+Evan%22">Lewis-Healey, Evan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pallavicini%2C+Carla%22">Pallavicini, Carla</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cavanna%2C+Federico%22">Cavanna, Federico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22D'Amelio%2C+Tomas%22">D'Amelio, Tomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+La+Fuente%2C+Laura+Alethia%22">De La Fuente, Laura Alethia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Copa%2C+Debora%22">Copa, Debora</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Müller%2C+Stephanie%22">Müller, Stephanie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bruno%2C+Nicolas%22">Bruno, Nicolas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tagliazucchi%2C+Enzo%22">Tagliazucchi, Enzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bekinschtein%2C+Tristan%22">Bekinschtein, Tristan</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Cognitive+Neuroscience%22">Journal of Cognitive Neuroscience</searchLink>. Jun2026, Vol. 38 Issue 6, p1244-1263. 20p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Dimethyltryptamine%22">Dimethyltryptamine</searchLink><br /><searchLink fieldCode="DE" term="%22Electroencephalography%22">Electroencephalography</searchLink><br /><searchLink fieldCode="DE" term="%22Hallucinogenic+drugs%22">Hallucinogenic drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Hallucinations%22">Hallucinations</searchLink><br /><searchLink fieldCode="DE" term="%22Neurophysiology%22">Neurophysiology</searchLink><br /><searchLink fieldCode="DE" term="%22Consciousness%22">Consciousness</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: N,N-dimethyltryptamine (DMT) is a fast-acting psychedelic drug that induces a radical reorganization of conscious contents and brain dynamics. However, our understanding of how brain dynamics support psychedelic-induced conscious states remains unclear. We therefore present a repeated-measures dose-dependent study of the subjective and neural dynamics induced through DMT under naturalistic conditions. Nineteen participants received either a 20-mg or a 40-mg dose of freebase DMT across two sessions in a blinded, counterbalanced order. Electroencephalography data and time-resolved measures of subjective experience (Temporal Experience Tracing) were collected. Both doses of DMT induced rapid changes in experience dimensions, with the 40-mg dose inducing more extreme visual hallucinations and emotionally intense experiences. A variety of neural features were computed on the electroencephalography data, with oscillatory alpha power and permutation entropy most strongly associated with continuous subjective experience dimensions. Strikingly, Lempel–Ziv complexity, previously hailed as a robust correlate of subjective experiences within the psychedelic state, yielded the weakest associations. These findings suggest that the relationship between neural complexity and phenomenology in psychedelic states is less clear than originally hypothesized. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=194131763
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1162/JOCN.a.2423
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 20
        StartPage: 1244
    Subjects:
      – SubjectFull: Dimethyltryptamine
        Type: general
      – SubjectFull: Electroencephalography
        Type: general
      – SubjectFull: Hallucinogenic drugs
        Type: general
      – SubjectFull: Hallucinations
        Type: general
      – SubjectFull: Neurophysiology
        Type: general
      – SubjectFull: Consciousness
        Type: general
    Titles:
      – TitleFull: Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine (DMT).
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lewis-Healey, Evan
      – PersonEntity:
          Name:
            NameFull: Pallavicini, Carla
      – PersonEntity:
          Name:
            NameFull: Cavanna, Federico
      – PersonEntity:
          Name:
            NameFull: D'Amelio, Tomas
      – PersonEntity:
          Name:
            NameFull: De La Fuente, Laura Alethia
      – PersonEntity:
          Name:
            NameFull: Copa, Debora
      – PersonEntity:
          Name:
            NameFull: Müller, Stephanie
      – PersonEntity:
          Name:
            NameFull: Bruno, Nicolas
      – PersonEntity:
          Name:
            NameFull: Tagliazucchi, Enzo
      – PersonEntity:
          Name:
            NameFull: Bekinschtein, Tristan
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 0898929X
          Numbering:
            – Type: volume
              Value: 38
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Journal of Cognitive Neuroscience
              Type: main
ResultId 1