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Insomnia is associated with psychological distress in individuals with methamphetamine dependence.

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Title: Insomnia is associated with psychological distress in individuals with methamphetamine dependence.
Authors: Matepi, Quinton G. J. (AUTHOR), Clifford, Brendan (AUTHOR), Acheson, Liam S. (AUTHOR), McKetin, Rebecca (AUTHOR), Montebello, Mark (AUTHOR), Siefried, Krista J. (AUTHOR), Chan, David K. E. (AUTHOR), Olsen, Nick (AUTHOR), May, Robert (AUTHOR), Ezard, Nadine (AUTHOR)
Source: Australasian Psychiatry. Jun2026, Vol. 34 Issue 3, p246-252. 7p.
Subjects: Insomnia, Psychological distress, Treatment programs, Mental depression, Sleep, Anxiety, Psychological stress, Methamphetamine abuse
Abstract: Introduction: Methamphetamine dependence is associated with psychological distress (stress, anxiety, and depression). Insomnia is common in this population, yet its association with distress remains underexplored. This study examined the relationship between insomnia severity and psychological distress in treatment-seeking individuals with methamphetamine dependence. Methods: This is a secondary cross-sectional analysis of baseline data from 152 participants enrolled in a randomised controlled trial of lisdexamfetamine versus placebo for methamphetamine dependence. Insomnia severity was assessed using the Insomnia Severity Index (ISI), and distress was measured via the Depression Anxiety and Stress Scale (DASS-21). Associations were analysed using Spearman's correlations and regression models adjusted for demographics, methamphetamine use, concomitant medication, and co-occurring distress. Results: Insomnia severity showed moderate correlations with depression, anxiety, stress, and total distress (ρ = 0.46–0.59, p <.001). In adjusted models, insomnia remained associated with distress: each 1-point ISI increase related to a 2.1–2.5% rise in DASS-21 depression and stress scores (β = 0.021–0.025, p =.003–.007), and a 6.5% increase in total scores (β = 0.063, p <.001); the association with anxiety was attenuated. Conclusions: Our study identified insomnia as an independent correlate of psychological distress in treatment-seeking individuals with methamphetamine dependence. Findings underscore sleep problems' relevance and support further research into sleep-focused interventions. [ABSTRACT FROM AUTHOR]
Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Insomnia is associated with psychological distress in individuals with methamphetamine dependence.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Matepi%2C+Quinton+G%2E+J%2E%22&quot;&gt;Matepi, Quinton G. J.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Clifford%2C+Brendan%22&quot;&gt;Clifford, Brendan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Acheson%2C+Liam+S%2E%22&quot;&gt;Acheson, Liam S.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22McKetin%2C+Rebecca%22&quot;&gt;McKetin, Rebecca&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Montebello%2C+Mark%22&quot;&gt;Montebello, Mark&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Siefried%2C+Krista+J%2E%22&quot;&gt;Siefried, Krista J.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chan%2C+David+K%2E+E%2E%22&quot;&gt;Chan, David K. E.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Olsen%2C+Nick%22&quot;&gt;Olsen, Nick&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22May%2C+Robert%22&quot;&gt;May, Robert&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ezard%2C+Nadine%22&quot;&gt;Ezard, Nadine&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Australasian+Psychiatry%22&quot;&gt;Australasian Psychiatry&lt;/searchLink&gt;. Jun2026, Vol. 34 Issue 3, p246-252. 7p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Insomnia%22&quot;&gt;Insomnia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychological+distress%22&quot;&gt;Psychological distress&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Treatment+programs%22&quot;&gt;Treatment programs&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression%22&quot;&gt;Mental depression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sleep%22&quot;&gt;Sleep&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Anxiety%22&quot;&gt;Anxiety&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychological+stress%22&quot;&gt;Psychological stress&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Methamphetamine+abuse%22&quot;&gt;Methamphetamine abuse&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Methamphetamine dependence is associated with psychological distress (stress, anxiety, and depression). Insomnia is common in this population, yet its association with distress remains underexplored. This study examined the relationship between insomnia severity and psychological distress in treatment-seeking individuals with methamphetamine dependence. Methods: This is a secondary cross-sectional analysis of baseline data from 152 participants enrolled in a randomised controlled trial of lisdexamfetamine versus placebo for methamphetamine dependence. Insomnia severity was assessed using the Insomnia Severity Index (ISI), and distress was measured via the Depression Anxiety and Stress Scale (DASS-21). Associations were analysed using Spearman&#39;s correlations and regression models adjusted for demographics, methamphetamine use, concomitant medication, and co-occurring distress. Results: Insomnia severity showed moderate correlations with depression, anxiety, stress, and total distress (ρ = 0.46–0.59, p &lt;.001). In adjusted models, insomnia remained associated with distress: each 1-point ISI increase related to a 2.1–2.5% rise in DASS-21 depression and stress scores (β = 0.021–0.025, p =.003–.007), and a 6.5% increase in total scores (β = 0.063, p &lt;.001); the association with anxiety was attenuated. Conclusions: Our study identified insomnia as an independent correlate of psychological distress in treatment-seeking individuals with methamphetamine dependence. Findings underscore sleep problems&#39; relevance and support further research into sleep-focused interventions. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1177/10398562251406035
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 246
    Subjects:
      – SubjectFull: Insomnia
        Type: general
      – SubjectFull: Psychological distress
        Type: general
      – SubjectFull: Treatment programs
        Type: general
      – SubjectFull: Mental depression
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      – SubjectFull: Sleep
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      – SubjectFull: Anxiety
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      – SubjectFull: Psychological stress
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      – SubjectFull: Methamphetamine abuse
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      – TitleFull: Insomnia is associated with psychological distress in individuals with methamphetamine dependence.
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              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
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