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Actionable medications in Australian Vietnam War veterans: Implications for pre-emptive pharmacogenetic testing.

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Title: Actionable medications in Australian Vietnam War veterans: Implications for pre-emptive pharmacogenetic testing.
Authors: Tan, Wei Liang Andre (AUTHOR), Mellor, Rebecca (AUTHOR), Bennett, Darcy (AUTHOR), Shu, Danhua (AUTHOR), Leite de Castro, Cecilia Werneck de Senna (AUTHOR), Voisey, Joanne (AUTHOR), Guindalini, Camila (AUTHOR), Semmler, Annalese (AUTHOR)
Source: Australasian Psychiatry. Jun2026, Vol. 34 Issue 3, p275-283. 9p.
Subjects: Cytochrome P-450 CYP2C19, Polypharmacy, Drug interactions, Pharmacogenomics, Medication safety, Vietnam veterans, Drug metabolism, Predictive tests
Abstract: Purpose of research: Describe prescribing patterns in Australian Vietnam veterans, identify CYP2C19-metabolised medications using established pharmacogenetic (PGx) resources, characterise CYP2C19 profiles of veterans and assess the potential clinical impact of these medications. Major findings: Among 283 veterans with CYP2C19 profiles, 256 reported current medications use, with a mean prescribed medication of 5.4. Of these, 89 veterans (34.7%) were prescribed at least one medication with CYP2C19 PGx recommendation. Notably, 52 veterans (58.4%) had CYP2C19 profiles that may be at risk of therapeutic failure or adverse effects. Prescribed medications also included six CYP2C19 inhibitors and one inducer, with potential to induce phenoconversion and impact drug metabolism. Conclusion: Veterans experienced high levels of polypharmacy and frequently carried CYP2C19 phenotypes associated with increased risk of therapeutic failure or adverse effects. The presence of CYP2C19 inhibitors and inducers raises the potential for phenoconversion, where CYP2C19 profiles may be placed at risk. Given their similarities to the broader older population, these findings suggest that both groups may benefit from pre-emptive PGx testing. Furthermore, ongoing monitoring of drug–gene and drug–drug interactions remains essential to optimise medication safety and efficacy in these high-risk individuals. [ABSTRACT FROM AUTHOR]
Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Actionable medications in Australian Vietnam War veterans: Implications for pre-emptive pharmacogenetic testing.
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  Data: <searchLink fieldCode="JN" term="%22Australasian+Psychiatry%22">Australasian Psychiatry</searchLink>. Jun2026, Vol. 34 Issue 3, p275-283. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Cytochrome+P-450+CYP2C19%22">Cytochrome P-450 CYP2C19</searchLink><br /><searchLink fieldCode="DE" term="%22Polypharmacy%22">Polypharmacy</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+interactions%22">Drug interactions</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacogenomics%22">Pharmacogenomics</searchLink><br /><searchLink fieldCode="DE" term="%22Medication+safety%22">Medication safety</searchLink><br /><searchLink fieldCode="DE" term="%22Vietnam+veterans%22">Vietnam veterans</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+metabolism%22">Drug metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Predictive+tests%22">Predictive tests</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Purpose of research: Describe prescribing patterns in Australian Vietnam veterans, identify CYP2C19-metabolised medications using established pharmacogenetic (PGx) resources, characterise CYP2C19 profiles of veterans and assess the potential clinical impact of these medications. Major findings: Among 283 veterans with CYP2C19 profiles, 256 reported current medications use, with a mean prescribed medication of 5.4. Of these, 89 veterans (34.7%) were prescribed at least one medication with CYP2C19 PGx recommendation. Notably, 52 veterans (58.4%) had CYP2C19 profiles that may be at risk of therapeutic failure or adverse effects. Prescribed medications also included six CYP2C19 inhibitors and one inducer, with potential to induce phenoconversion and impact drug metabolism. Conclusion: Veterans experienced high levels of polypharmacy and frequently carried CYP2C19 phenotypes associated with increased risk of therapeutic failure or adverse effects. The presence of CYP2C19 inhibitors and inducers raises the potential for phenoconversion, where CYP2C19 profiles may be placed at risk. Given their similarities to the broader older population, these findings suggest that both groups may benefit from pre-emptive PGx testing. Furthermore, ongoing monitoring of drug–gene and drug–drug interactions remains essential to optimise medication safety and efficacy in these high-risk individuals. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1177/10398562251408237
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 275
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      – SubjectFull: Cytochrome P-450 CYP2C19
        Type: general
      – SubjectFull: Polypharmacy
        Type: general
      – SubjectFull: Drug interactions
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      – SubjectFull: Pharmacogenomics
        Type: general
      – SubjectFull: Medication safety
        Type: general
      – SubjectFull: Vietnam veterans
        Type: general
      – SubjectFull: Drug metabolism
        Type: general
      – SubjectFull: Predictive tests
        Type: general
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      – TitleFull: Actionable medications in Australian Vietnam War veterans: Implications for pre-emptive pharmacogenetic testing.
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              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
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