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Aberrant fronto-limbic network in adolescents with attention-deficit/hyperactivity disorder: a multimodal MRI study using parallel ICA.

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Title: Aberrant fronto-limbic network in adolescents with attention-deficit/hyperactivity disorder: a multimodal MRI study using parallel ICA.
Authors: He, Jingqi (AUTHOR), Li, Jinguang (AUTHOR), Pei, Hongdi (AUTHOR), Benhouhou, Ismael (AUTHOR), He, Zhangyin (AUTHOR), Gu, Lin (AUTHOR), Tang, Jinsong (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Jun2026, Vol. 276 Issue 4, p1671-1682. 12p.
Subjects: Attention-deficit hyperactivity disorder, Independent component analysis, Teenagers, Prefrontal cortex, Functional magnetic resonance imaging, Brain anatomy, Cognitive ability, Neural development
Abstract: Background: Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental conditions in children and adolescents, characterized as inattentive, impulsive, and hyperactive. Numerous magnetic resonance imaging (MRI) studies have revealed atypical brain function and structure in ADHD, and multimodal MRI studies contribute to a better understanding of the neurobiological underpinnings of ADHD. Methods: The demographic and clinical information and the structural and functional MRI scans used in this study were all obtained from the New York University Child Study Center site of the ADHD-200 database. Forty-eight typically developing children (TDC) and 87 boys with ADHD were included. Parallel independent component analysis (pICA) was performed to the fusion of fractional amplitude of low-frequency fluctuation (fALFF) and gray matter volume (GMV). Result: We found two correlated component pairs, containing the anterior cingulate cortex, orbitofrontal cortex, and amygdala. Based on the spatial patterns of both functional and structural components, both IC pairs were classified as representing the fronto-limbic network. One component pair showed significant group differences in loading coefficients between the ADHD and TDC groups. However, no correlations between structural or functional alterations and symptom or cognitive function were observed. Conclusion: Using parallel ICA, we identified two correlated IC pairs involving regions of the fronto-limbic network across all participants, suggesting structure-function coupling within this network during adolescence. One of these IC pairs showed significant group differences in loading coefficients between ADHD and TDC participants, indicating a partial disruption of fronto-limbic structure-function integration in the ADHD group. Future studies should examine the link between these alterations and specific symptom dimensions. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Aberrant fronto-limbic network in adolescents with attention-deficit/hyperactivity disorder: a multimodal MRI study using parallel ICA.
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  Data: <searchLink fieldCode="AR" term="%22He%2C+Jingqi%22">He, Jingqi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Jinguang%22">Li, Jinguang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pei%2C+Hongdi%22">Pei, Hongdi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Benhouhou%2C+Ismael%22">Benhouhou, Ismael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22He%2C+Zhangyin%22">He, Zhangyin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gu%2C+Lin%22">Gu, Lin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Jinsong%22">Tang, Jinsong</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Jun2026, Vol. 276 Issue 4, p1671-1682. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Independent+component+analysis%22">Independent component analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Teenagers%22">Teenagers</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+anatomy%22">Brain anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink>
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  Data: Background: Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental conditions in children and adolescents, characterized as inattentive, impulsive, and hyperactive. Numerous magnetic resonance imaging (MRI) studies have revealed atypical brain function and structure in ADHD, and multimodal MRI studies contribute to a better understanding of the neurobiological underpinnings of ADHD. Methods: The demographic and clinical information and the structural and functional MRI scans used in this study were all obtained from the New York University Child Study Center site of the ADHD-200 database. Forty-eight typically developing children (TDC) and 87 boys with ADHD were included. Parallel independent component analysis (pICA) was performed to the fusion of fractional amplitude of low-frequency fluctuation (fALFF) and gray matter volume (GMV). Result: We found two correlated component pairs, containing the anterior cingulate cortex, orbitofrontal cortex, and amygdala. Based on the spatial patterns of both functional and structural components, both IC pairs were classified as representing the fronto-limbic network. One component pair showed significant group differences in loading coefficients between the ADHD and TDC groups. However, no correlations between structural or functional alterations and symptom or cognitive function were observed. Conclusion: Using parallel ICA, we identified two correlated IC pairs involving regions of the fronto-limbic network across all participants, suggesting structure-function coupling within this network during adolescence. One of these IC pairs showed significant group differences in loading coefficients between ADHD and TDC participants, indicating a partial disruption of fronto-limbic structure-function integration in the ADHD group. Future studies should examine the link between these alterations and specific symptom dimensions. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jun2026
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