Developmental Perspectives on Eating Disorders: A Review and Research Update on the ABCD Study.

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Title: Developmental Perspectives on Eating Disorders: A Review and Research Update on the ABCD Study.
Authors: Martin, Elizabeth (AUTHOR), Schulz, Kurt P. (AUTHOR), Hildebrandt, Tom (AUTHOR), Sysko, Robyn (AUTHOR), Li, Xiaobo (AUTHOR)
Source: International Journal of Eating Disorders. Jun2026, Vol. 59 Issue 6, p1195-1207. 13p.
Subjects: Risk assessment, Data analysis, T-test (Statistics), Research funding, Magnetic resonance imaging, Descriptive statistics, Classification of mental disorders, Eating disorders, Systematic reviews, MEDLINE, Statistics, Online information services, Adolescence
Abstract: Objective: Numerous publications utilize data from the Adolescent Brain and Cognitive Development (ABCD) Study. This review aimed to evaluate how data from the ABCD cohort contributes to understanding the pathophysiology of incipient eating disorders. Method: Searches were completed using PubMed and the ABCD Study research publications database. All available neuroimaging articles assessing prevalence and predictors of disordered eating/eating disorders were included. Results: Thirty‐eight articles met inclusion criteria, 10 of which presented neuroimaging results, all analyzing baseline brain data. The majority (n = 9) assessed brain structure and function in children with binge eating (BE)/binge eating disorder (BED). Results were inconsistent across imaging modalities. Structural MRI studies included widespread increases in gray matter density and reductions in cortical thickness associated with eating pathology. Task‐based fMRI studies reported conflicting findings, with frontostriatal activation during reward processing in children with BE/BED reduced, increased, or not different compared to controls. Resting‐state fMRI analyses consistently identified reduced functional connectivity in key frontal circuits, although patterns differed when samples were stratified by sex or BMI. Non‐imaging studies showed positive associations between eating disorders/disordered eating and several sociodemographic, cognitive, behavioral, and biological correlates. Discussion: Alterations in brain structure and function associated with binge eating are identified in neuroimaging analyses of baseline scans from the ABCD cohort, with inconsistent results. One potential pattern suggests alterations in reward system function, although the direction and exact location of such alterations are unclear. Consistency in methodological approaches is necessary to allow patterns in neural alterations to be more clearly identified. There is significant and ongoing potential for the ABCD Study dataset to quantify developmental aspects of binge eating. Recommendations for future analyses as the sample progresses through puberty and eating disorder prevalence increases are also presented. Summary Points: The ABCD Study offers a unique opportunity to analyze the etiology and trajectory of disordered eating and eating disorders.Thirty‐eight studies, 10 of which used neuroimaging, have analyzed data from the ABCD Study. While there are some patterns emerging, for example, reward system abnormalities, a clear neural signature for pediatric eating disorders/disordered eating has emerged.While there is great potential for the ABCD Study dataset, the lack of consistent results reported to date is disappointing. Ongoing analysis of ABCD Study data must ensure methodological transparency and rigor. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Developmental Perspectives on Eating Disorders: A Review and Research Update on the ABCD Study.
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  Data: <searchLink fieldCode="AR" term="%22Martin%2C+Elizabeth%22">Martin, Elizabeth</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schulz%2C+Kurt+P%2E%22">Schulz, Kurt P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hildebrandt%2C+Tom%22">Hildebrandt, Tom</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sysko%2C+Robyn%22">Sysko, Robyn</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Xiaobo%22">Li, Xiaobo</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Eating+Disorders%22">International Journal of Eating Disorders</searchLink>. Jun2026, Vol. 59 Issue 6, p1195-1207. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Classification+of+mental+disorders%22">Classification of mental disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Eating+disorders%22">Eating disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Online+information+services%22">Online information services</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Numerous publications utilize data from the Adolescent Brain and Cognitive Development (ABCD) Study. This review aimed to evaluate how data from the ABCD cohort contributes to understanding the pathophysiology of incipient eating disorders. Method: Searches were completed using PubMed and the ABCD Study research publications database. All available neuroimaging articles assessing prevalence and predictors of disordered eating/eating disorders were included. Results: Thirty‐eight articles met inclusion criteria, 10 of which presented neuroimaging results, all analyzing baseline brain data. The majority (n = 9) assessed brain structure and function in children with binge eating (BE)/binge eating disorder (BED). Results were inconsistent across imaging modalities. Structural MRI studies included widespread increases in gray matter density and reductions in cortical thickness associated with eating pathology. Task‐based fMRI studies reported conflicting findings, with frontostriatal activation during reward processing in children with BE/BED reduced, increased, or not different compared to controls. Resting‐state fMRI analyses consistently identified reduced functional connectivity in key frontal circuits, although patterns differed when samples were stratified by sex or BMI. Non‐imaging studies showed positive associations between eating disorders/disordered eating and several sociodemographic, cognitive, behavioral, and biological correlates. Discussion: Alterations in brain structure and function associated with binge eating are identified in neuroimaging analyses of baseline scans from the ABCD cohort, with inconsistent results. One potential pattern suggests alterations in reward system function, although the direction and exact location of such alterations are unclear. Consistency in methodological approaches is necessary to allow patterns in neural alterations to be more clearly identified. There is significant and ongoing potential for the ABCD Study dataset to quantify developmental aspects of binge eating. Recommendations for future analyses as the sample progresses through puberty and eating disorder prevalence increases are also presented. Summary Points: The ABCD Study offers a unique opportunity to analyze the etiology and trajectory of disordered eating and eating disorders.Thirty‐eight studies, 10 of which used neuroimaging, have analyzed data from the ABCD Study. While there are some patterns emerging, for example, reward system abnormalities, a clear neural signature for pediatric eating disorders/disordered eating has emerged.While there is great potential for the ABCD Study dataset, the lack of consistent results reported to date is disappointing. Ongoing analysis of ABCD Study data must ensure methodological transparency and rigor. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/eat.70066
    Languages:
      – Code: eng
        Text: English
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        PageCount: 13
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      – SubjectFull: Risk assessment
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      – SubjectFull: Data analysis
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      – SubjectFull: T-test (Statistics)
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      – SubjectFull: Research funding
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      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Classification of mental disorders
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      – SubjectFull: Online information services
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      – SubjectFull: Adolescence
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      – TitleFull: Developmental Perspectives on Eating Disorders: A Review and Research Update on the ABCD Study.
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              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
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