Dopamine modulation of aggression.
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| Title: | Dopamine modulation of aggression. |
|---|---|
| Authors: | Dai, Bing (AUTHOR), Lin, Dayu (AUTHOR) |
| Source: | Psychopharmacology. May2026, Vol. 243 Issue 5, p925-948. 24p. |
| Subjects: | Dopamine, Aggression (Psychology), Antipsychotic agents, Genetics, Neural circuitry, Social psychology, Reward (Psychology), Pharmacology |
| Abstract: | Rationale: Aggression is an innate social behavior prevalent across animal species. However, in modern human society, inter-personal aggression is considered disruptive and detrimental to both families and communities. Clinically, antipsychotics, which primarily target dopamine (DA) receptors, have been widely used to suppress hyper-aggression. However, the mechanisms underlying the effect of the antipsychotics remain incompletely understood. Objectives: We reviewed key steps in brain DA synthesis and summarized genetic and pharmacological evidence supporting the role of the mesolimbic DA system in aggression. Next, we discussed recent circuit studies that elucidate the DA action in modulating aggression-related brain regions. These lines of evidence collectively suggest that DA acts on different brain regions to facilitate aggression and self-learning, and signals the valence of the fighting experience. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 194358474 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dopamine modulation of aggression. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dai%2C+Bing%22">Dai, Bing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Dayu%22">Lin, Dayu</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. May2026, Vol. 243 Issue 5, p925-948. 24p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Aggression+%28Psychology%29%22">Aggression (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+circuitry%22">Neural circuitry</searchLink><br /><searchLink fieldCode="DE" term="%22Social+psychology%22">Social psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Reward+%28Psychology%29%22">Reward (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacology%22">Pharmacology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Aggression is an innate social behavior prevalent across animal species. However, in modern human society, inter-personal aggression is considered disruptive and detrimental to both families and communities. Clinically, antipsychotics, which primarily target dopamine (DA) receptors, have been widely used to suppress hyper-aggression. However, the mechanisms underlying the effect of the antipsychotics remain incompletely understood. Objectives: We reviewed key steps in brain DA synthesis and summarized genetic and pharmacological evidence supporting the role of the mesolimbic DA system in aggression. Next, we discussed recent circuit studies that elucidate the DA action in modulating aggression-related brain regions. These lines of evidence collectively suggest that DA acts on different brain regions to facilitate aggression and self-learning, and signals the valence of the fighting experience. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=194358474 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-025-06893-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 24 StartPage: 925 Subjects: – SubjectFull: Dopamine Type: general – SubjectFull: Aggression (Psychology) Type: general – SubjectFull: Antipsychotic agents Type: general – SubjectFull: Genetics Type: general – SubjectFull: Neural circuitry Type: general – SubjectFull: Social psychology Type: general – SubjectFull: Reward (Psychology) Type: general – SubjectFull: Pharmacology Type: general Titles: – TitleFull: Dopamine modulation of aggression. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dai, Bing – PersonEntity: Name: NameFull: Lin, Dayu IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 243 – Type: issue Value: 5 Titles: – TitleFull: Psychopharmacology Type: main |
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