Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo.
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| Title: | Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo. |
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| Authors: | Coles, Brenda L. K. (AUTHOR), Horsford, D. Jonathan (AUTHOR), McInnes, Roderick R. (AUTHOR), Kooy, Derek (AUTHOR) |
| Source: | European Journal of Neuroscience. Jan2006, Vol. 23 Issue 1, p75-82. 8p. 5 Graphs. |
| Subjects: | Retina cytology, Stem cells, Retina, Cell proliferation, Cell populations, Cytology |
| Abstract: | Retinal stem cells [with the potential to produce either neural retinal progenitors or retinal pigment epithelial (RPE) progenitors] exist in the mammalian eye throughout life, and indeed the greatest absolute increase in the stem population occurs postnatally. The stem cells proliferate embryonically and thus may help to build the retina initially, but in postnatal mammals they clearly do not proliferate to regenerate the retina in response to injury. Using Chx10 orJ/orJ and Mitf mi/mi mice, with small eye phenotypes due to the reduction of the neural retinal progenitor population and the retinal pigmented epithelial progenitor population, respectively, we now report that the retinal stem cell population, when assayed from the ciliary margin, increases 3–8-fold in both mutants. These findings suggest that the mammalian retinal stem cell population may be capable of responding to genetically induced signals from the progenitor populations. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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