Relationship Between Smoking and Psychiatric and Somatic Comorbidities in Older Age Bipolar Disorder: Lien entre le tabagisme et les affections psychiatriques et somatiques concomitantes chez les personnes âgées atteintes de trouble bipolaire.
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| Title: | Relationship Between Smoking and Psychiatric and Somatic Comorbidities in Older Age Bipolar Disorder: Lien entre le tabagisme et les affections psychiatriques et somatiques concomitantes chez les personnes âgées atteintes de trouble bipolaire. |
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| Authors: | Howland, Molly (AUTHOR), Mahajan, Arushi (AUTHOR), Chen, Peijun (AUTHOR), Almeida, Osvaldo (AUTHOR), Altınbaş, Kürşat (AUTHOR), Blumberg, Hilary (AUTHOR), Dols, Annemiek (AUTHOR), Fiorelli, Nicole (AUTHOR), Forlenza, Orestes (AUTHOR), Lafer, Beny (AUTHOR), Olagunju, Andrew (AUTHOR), Orhan, Melis (AUTHOR), Rej, Soham (AUTHOR), Sajatovic, Martha (AUTHOR), Schurr, Matthew (AUTHOR), Simhandl, Christian (AUTHOR), Soares, Jair (AUTHOR), Sutherland, Ashley (AUTHOR), Tsai, Shang-ying (AUTHOR), Weisenbach, Sara (AUTHOR) |
| Source: | Canadian Journal of Psychiatry. Jul2026, Vol. 71 Issue 7, p575-585. 11p. |
| Subjects: | Smoking, Bipolar disorder, Substance-induced disorders, Mental depression, Comorbidity, Older people, Cardiovascular diseases |
| Abstract (English): | Objective: Smoking has been associated with psychiatric and somatic comorbidities in bipolar disorder (BD) populations. However, studies in older age BD (OABD) populations are sparse. We hypothesized that among individuals with OABD, current and former smokers would have worse psychiatric and somatic comorbidities parameters compared to never smokers. Method: Our study used baseline cross-sectional data from 27 international studies reporting data on adults 50 years old and older (N = 984). Smoking status was categorized into current smokers, former smokers, and never smokers. The distribution of demographic and clinical variables was assessed. The associations between smoking status and the clinical variables were examined using multivariable models that adjusted for age, sex, and study. Multivariable models were repeated, restricting to individuals with and without cardiovascular or respiratory (cardiorespiratory) comorbidity. Results: Our study sample was 52.8% female with a mean age of 62 years and included 347 (35.3%) never smokers, 222 (22.6%) former smokers, and 415 (42.2%) current smokers. After controlling for age, sex, and study, current depression was more prevalent in former versus never smokers and current versus never smokers. Cardiovascular comorbidity was more prevalent among former than never smokers. More current versus never smokers were taking antipsychotic medications and more current versus never smokers having lifetime substance use disorders. When stratifying by the presence of cardiorespiratory comorbidity, the only statistically significant association was higher functioning in never versus current smokers in participants without cardiorespiratory comorbidity, though non-statistically significant relationships were present between lifetime smoking and depression across strata. Conclusions: The relationship of smoking with depression and substance use disorders is largely independent of age, sex, and, for the depression relationship, cardiorespiratory comorbidity. More smokers taking antipsychotic medications suggests that smoking is associated with a more severe BD course. Cardiovascular comorbidity may serve as a motivating factor for smoking cessation. Plain Language Summary: This study examines how smoking impacts mental and physical health in older adults with bipolar disorder (BD). It compares the health of individuals aged 50 and older with BD who currently smoke with those who formerly smoked and those who have never smoked. The study found that smoking is linked with worse health outcomes in this population. It shows that depression, cardiovascular issues, and possibly substance use disorders are more common in those who smoke than those who never smoked. As cardiovascular issues are especially common in patients who formerly smoked, these cardiovascular issues may motivate individuals with BD to quit smoking. [ABSTRACT FROM AUTHOR] |
| Abstract (French): | Le tabagisme est associé à des affections psychiatriques et somatiques concomitantes chez les personnes atteintes de trouble bipolaire (TB). Toutefois, les études portant sur des personnes âgées atteintes de TB (PATB) sont rares. Nous avons émis l'hypothèse que parmi les PATB, les personnes n'ayant jamais fumé obtiendraient de meilleurs résultats en matière de paramètres relatifs aux affections psychiatriques et somatiques concomitantes que ceux des fumeurs actuels ou des anciens fumeurs. Notre étude s'est appuyée sur des données transversales de référence provenant de 27 études internationales menées auprès d'adultes de 50 ans et plus (N = 984). Le statut tabagique a été classé en trois catégories : fumeurs actuels, anciens fumeurs et personnes n'ayant jamais fumé. La répartition des variables démographiques et cliniques a fait l'objet d'une évaluation. Les associations entre le statut tabagique et les variables cliniques ont été examinées à l'aide de modèles multivariables ajustés en fonction de l'âge, du sexe et de l'étude. L'utilisation de modèles multivariables a été répétée en se limitant aux personnes atteintes ou non d'affections cardiovasculaires ou respiratoires (cardiorespiratoires) concomitantes. Notre échantillon était composé à 52,8% de femmes, dont l'âge moyen était de 62 ans, et comprenait 347 (35,3%) personnes n'ayant jamais fumé, 222 (22,6%) anciens fumeurs et 415 (42,2%) fumeurs actuels. Après avoir pris en compte l'âge, le sexe et l'étude, la dépression actuelle était plus fréquente chez les anciens fumeurs et les fumeurs actuels que chez les personnes n'ayant jamais fumé. Les affections cardiovasculaires concomitantes étaient plus fréquentes chez les anciens fumeurs que chez les personnes n'ayant jamais fumé. Les fumeurs actuels étaient plus nombreux à prendre des antipsychotiques et à présenter des troubles liés à l'utilisation de substances psychoactives au cours de leur vie que les personnes n'ayant jamais fumé. Lors de la stratification en fonction de la présence d'affections cardiorespiratoires concomitantes, la seule association statistiquement significative était un meilleur fonctionnement chez les personnes n'ayant jamais fumé que chez les fumeurs actuels parmi les participants ne présentant pas d'affections cardiorespiratoires concomitantes, même si des associations non statistiquement significatives ont été observées entre l'usage du tabac au cours de la vie et la dépression dans toutes les strates. Le lien entre le tabagisme, la dépression et les troubles liés à l'utilisation de substances psychoactives est largement indépendant de l'âge et du sexe. Le lien avec la dépression est indépendant de la présence d'affections cardiorespiratoires concomitantes. Le fait que davantage de fumeurs prennent des antipsychotiques indique que le tabagisme est associé à une évolution vers un stade plus grave de trouble bipolaire. Les affections cardiovasculaires concomitantes peuvent servir de facteur de motivation pour arrêter de fumer. [ABSTRACT FROM AUTHOR] |
| Copyright of Canadian Journal of Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 194393516 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Relationship Between Smoking and Psychiatric and Somatic Comorbidities in Older Age Bipolar Disorder: Lien entre le tabagisme et les affections psychiatriques et somatiques concomitantes chez les personnes âgées atteintes de trouble bipolaire. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Howland%2C+Molly%22">Howland, Molly</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mahajan%2C+Arushi%22">Mahajan, Arushi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Peijun%22">Chen, Peijun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Almeida%2C+Osvaldo%22">Almeida, Osvaldo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Altınbaş%2C+Kürşat%22">Altınbaş, Kürşat</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blumberg%2C+Hilary%22">Blumberg, Hilary</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dols%2C+Annemiek%22">Dols, Annemiek</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fiorelli%2C+Nicole%22">Fiorelli, Nicole</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Forlenza%2C+Orestes%22">Forlenza, Orestes</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lafer%2C+Beny%22">Lafer, Beny</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Olagunju%2C+Andrew%22">Olagunju, Andrew</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Orhan%2C+Melis%22">Orhan, Melis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rej%2C+Soham%22">Rej, Soham</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sajatovic%2C+Martha%22">Sajatovic, Martha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schurr%2C+Matthew%22">Schurr, Matthew</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Simhandl%2C+Christian%22">Simhandl, Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soares%2C+Jair%22">Soares, Jair</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sutherland%2C+Ashley%22">Sutherland, Ashley</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tsai%2C+Shang-ying%22">Tsai, Shang-ying</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Weisenbach%2C+Sara%22">Weisenbach, Sara</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Canadian+Journal+of+Psychiatry%22">Canadian Journal of Psychiatry</searchLink>. Jul2026, Vol. 71 Issue 7, p575-585. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Smoking%22">Smoking</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Substance-induced+disorders%22">Substance-induced disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Older+people%22">Older people</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+diseases%22">Cardiovascular diseases</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Objective: Smoking has been associated with psychiatric and somatic comorbidities in bipolar disorder (BD) populations. However, studies in older age BD (OABD) populations are sparse. We hypothesized that among individuals with OABD, current and former smokers would have worse psychiatric and somatic comorbidities parameters compared to never smokers. Method: Our study used baseline cross-sectional data from 27 international studies reporting data on adults 50 years old and older (N = 984). Smoking status was categorized into current smokers, former smokers, and never smokers. The distribution of demographic and clinical variables was assessed. The associations between smoking status and the clinical variables were examined using multivariable models that adjusted for age, sex, and study. Multivariable models were repeated, restricting to individuals with and without cardiovascular or respiratory (cardiorespiratory) comorbidity. Results: Our study sample was 52.8% female with a mean age of 62 years and included 347 (35.3%) never smokers, 222 (22.6%) former smokers, and 415 (42.2%) current smokers. After controlling for age, sex, and study, current depression was more prevalent in former versus never smokers and current versus never smokers. Cardiovascular comorbidity was more prevalent among former than never smokers. More current versus never smokers were taking antipsychotic medications and more current versus never smokers having lifetime substance use disorders. When stratifying by the presence of cardiorespiratory comorbidity, the only statistically significant association was higher functioning in never versus current smokers in participants without cardiorespiratory comorbidity, though non-statistically significant relationships were present between lifetime smoking and depression across strata. Conclusions: The relationship of smoking with depression and substance use disorders is largely independent of age, sex, and, for the depression relationship, cardiorespiratory comorbidity. More smokers taking antipsychotic medications suggests that smoking is associated with a more severe BD course. Cardiovascular comorbidity may serve as a motivating factor for smoking cessation. Plain Language Summary: This study examines how smoking impacts mental and physical health in older adults with bipolar disorder (BD). It compares the health of individuals aged 50 and older with BD who currently smoke with those who formerly smoked and those who have never smoked. The study found that smoking is linked with worse health outcomes in this population. It shows that depression, cardiovascular issues, and possibly substance use disorders are more common in those who smoke than those who never smoked. As cardiovascular issues are especially common in patients who formerly smoked, these cardiovascular issues may motivate individuals with BD to quit smoking. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (French) Group: Ab Data: Le tabagisme est associé à des affections psychiatriques et somatiques concomitantes chez les personnes atteintes de trouble bipolaire (TB). Toutefois, les études portant sur des personnes âgées atteintes de TB (PATB) sont rares. Nous avons émis l'hypothèse que parmi les PATB, les personnes n'ayant jamais fumé obtiendraient de meilleurs résultats en matière de paramètres relatifs aux affections psychiatriques et somatiques concomitantes que ceux des fumeurs actuels ou des anciens fumeurs. Notre étude s'est appuyée sur des données transversales de référence provenant de 27 études internationales menées auprès d'adultes de 50 ans et plus (N = 984). Le statut tabagique a été classé en trois catégories : fumeurs actuels, anciens fumeurs et personnes n'ayant jamais fumé. La répartition des variables démographiques et cliniques a fait l'objet d'une évaluation. Les associations entre le statut tabagique et les variables cliniques ont été examinées à l'aide de modèles multivariables ajustés en fonction de l'âge, du sexe et de l'étude. L'utilisation de modèles multivariables a été répétée en se limitant aux personnes atteintes ou non d'affections cardiovasculaires ou respiratoires (cardiorespiratoires) concomitantes. Notre échantillon était composé à 52,8% de femmes, dont l'âge moyen était de 62 ans, et comprenait 347 (35,3%) personnes n'ayant jamais fumé, 222 (22,6%) anciens fumeurs et 415 (42,2%) fumeurs actuels. Après avoir pris en compte l'âge, le sexe et l'étude, la dépression actuelle était plus fréquente chez les anciens fumeurs et les fumeurs actuels que chez les personnes n'ayant jamais fumé. Les affections cardiovasculaires concomitantes étaient plus fréquentes chez les anciens fumeurs que chez les personnes n'ayant jamais fumé. Les fumeurs actuels étaient plus nombreux à prendre des antipsychotiques et à présenter des troubles liés à l'utilisation de substances psychoactives au cours de leur vie que les personnes n'ayant jamais fumé. Lors de la stratification en fonction de la présence d'affections cardiorespiratoires concomitantes, la seule association statistiquement significative était un meilleur fonctionnement chez les personnes n'ayant jamais fumé que chez les fumeurs actuels parmi les participants ne présentant pas d'affections cardiorespiratoires concomitantes, même si des associations non statistiquement significatives ont été observées entre l'usage du tabac au cours de la vie et la dépression dans toutes les strates. Le lien entre le tabagisme, la dépression et les troubles liés à l'utilisation de substances psychoactives est largement indépendant de l'âge et du sexe. Le lien avec la dépression est indépendant de la présence d'affections cardiorespiratoires concomitantes. Le fait que davantage de fumeurs prennent des antipsychotiques indique que le tabagisme est associé à une évolution vers un stade plus grave de trouble bipolaire. Les affections cardiovasculaires concomitantes peuvent servir de facteur de motivation pour arrêter de fumer. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Canadian Journal of Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/07067437251387658 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 575 Subjects: – SubjectFull: Smoking Type: general – SubjectFull: Bipolar disorder Type: general – SubjectFull: Substance-induced disorders Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Comorbidity Type: general – SubjectFull: Older people Type: general – SubjectFull: Cardiovascular diseases Type: general Titles: – TitleFull: Relationship Between Smoking and Psychiatric and Somatic Comorbidities in Older Age Bipolar Disorder: Lien entre le tabagisme et les affections psychiatriques et somatiques concomitantes chez les personnes âgées atteintes de trouble bipolaire. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Howland, Molly – PersonEntity: Name: NameFull: Mahajan, Arushi – PersonEntity: Name: NameFull: Chen, Peijun – PersonEntity: Name: NameFull: Almeida, Osvaldo – PersonEntity: Name: NameFull: Altınbaş, Kürşat – PersonEntity: Name: NameFull: Blumberg, Hilary – PersonEntity: Name: NameFull: Dols, Annemiek – PersonEntity: Name: NameFull: Fiorelli, Nicole – PersonEntity: Name: NameFull: Forlenza, Orestes – PersonEntity: Name: NameFull: Lafer, Beny – PersonEntity: Name: NameFull: Olagunju, Andrew – PersonEntity: Name: NameFull: Orhan, Melis – PersonEntity: Name: NameFull: Rej, Soham – PersonEntity: Name: NameFull: Sajatovic, Martha – PersonEntity: Name: NameFull: Schurr, Matthew – PersonEntity: Name: NameFull: Simhandl, Christian – PersonEntity: Name: NameFull: Soares, Jair – PersonEntity: Name: NameFull: Sutherland, Ashley – PersonEntity: Name: NameFull: Tsai, Shang-ying – PersonEntity: Name: NameFull: Weisenbach, Sara IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 07067437 Numbering: – Type: volume Value: 71 – Type: issue Value: 7 Titles: – TitleFull: Canadian Journal of Psychiatry Type: main |
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