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miR‐126‐3p Inhibits Microglial M1 Polarization via the AKT2/NF‐κB Pathway to Alleviate Migraine Pain.

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Title: miR‐126‐3p Inhibits Microglial M1 Polarization via the AKT2/NF‐κB Pathway to Alleviate Migraine Pain.
Authors: Tan, Binjie (AUTHOR), Liu, Yu (AUTHOR), Wang, Qianqian (AUTHOR), Zuo, Shilun (AUTHOR), Fee, Dominic B. (AUTHOR)
Source: Acta Neurologica Scandinavica. 6/9/2026, Vol. 2026, p1-12. 12p.
Subjects: Microglia, Migraine, MicroRNA, Neuroinflammation, Cellular signal transduction, Inflammatory mediators
Abstract: Background and Objectives: Migraine is a debilitating neurological disorder characterized by severe headache and neuroinflammation. This study investigates the role of miR‐126‐3p in regulating microglial M2 polarization via the AKT2/NF‐κB pathway to alleviate migraine pain. Methods: We employed the mouse model of migraine induced by nitroglycerin (NTG) and the BV‐2 microglial cell model stimulated by lipopolysaccharide (LPS) to examine how miR‐126‐3p affects microglia and alleviates migraine pain. Results: Our findings indicate that miR‐126‐3p promotes the transformation of microglia from the M1 type to the M2 type by inhibiting the AKT2/NF‐κB pathway, thereby reducing the expression of proinflammatory factors. This alleviation of neuroinflammation alleviates the neural pain associated with migraine. Conclusions: miR‐126‐3p regulates the polarization morphology of microglia through the AKT2/NF‐κB pathway and plays a crucial role in modulating neuroinflammation in migraine. This discovery may pave the way for developing improved therapeutic strategies to manage migraine pain. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: miR‐126‐3p Inhibits Microglial M1 Polarization via the AKT2/NF‐κB Pathway to Alleviate Migraine Pain.
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  Data: <searchLink fieldCode="AR" term="%22Tan%2C+Binjie%22">Tan, Binjie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Yu%22">Liu, Yu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Qianqian%22">Wang, Qianqian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zuo%2C+Shilun%22">Zuo, Shilun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fee%2C+Dominic+B%2E%22">Fee, Dominic B.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 6/9/2026, Vol. 2026, p1-12. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Microglia%22">Microglia</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink><br /><searchLink fieldCode="DE" term="%22MicroRNA%22">MicroRNA</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroinflammation%22">Neuroinflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+signal+transduction%22">Cellular signal transduction</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammatory+mediators%22">Inflammatory mediators</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and Objectives: Migraine is a debilitating neurological disorder characterized by severe headache and neuroinflammation. This study investigates the role of miR‐126‐3p in regulating microglial M2 polarization via the AKT2/NF‐κB pathway to alleviate migraine pain. Methods: We employed the mouse model of migraine induced by nitroglycerin (NTG) and the BV‐2 microglial cell model stimulated by lipopolysaccharide (LPS) to examine how miR‐126‐3p affects microglia and alleviates migraine pain. Results: Our findings indicate that miR‐126‐3p promotes the transformation of microglia from the M1 type to the M2 type by inhibiting the AKT2/NF‐κB pathway, thereby reducing the expression of proinflammatory factors. This alleviation of neuroinflammation alleviates the neural pain associated with migraine. Conclusions: miR‐126‐3p regulates the polarization morphology of microglia through the AKT2/NF‐κB pathway and plays a crucial role in modulating neuroinflammation in migraine. This discovery may pave the way for developing improved therapeutic strategies to manage migraine pain. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/ane/3615132
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        Text: English
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        Type: general
      – SubjectFull: Migraine
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      – SubjectFull: MicroRNA
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      – SubjectFull: Neuroinflammation
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      – SubjectFull: Cellular signal transduction
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              Text: 6/9/2026
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              Y: 2026
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