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The Central Role of Oxidative Stress in the Pathogenesis of Obstructive Sleep Apnea Syndrome: Mechanisms, Biomarkers, and Clinical Implications.

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Title: The Central Role of Oxidative Stress in the Pathogenesis of Obstructive Sleep Apnea Syndrome: Mechanisms, Biomarkers, and Clinical Implications.
Authors: Öztürk, Mustafa Murat (AUTHOR)
Source: Journal of Turkish Sleep Medicine / Türk Uyku Tıbbı Dergisi. Jun2026, Vol. 13 Issue 2, p1-9. 9p.
Subjects: Sleep apnea syndrome treatment, Risk assessment, Superoxide dismutase, Metabolic disorders, Mitochondria, Adenosine triphosphate, Oxidative stress, Respiratory obstructions, Cardiovascular diseases risk factors, Reactive oxygen species, Reactive nitrogen species, Neurological disorders, Sleep apnea syndromes, Inflammation, Biomarkers, Hypoxemia, Disease risk factors, Disease complications
Abstract: Obstructive sleep apnea (OSA) syndrome is an increasingly prevalent sleep disorder characterized by recurrent upper airway obstructions and associated intermittent episodes of hypoxia. OSA is associated with cardiovascular, metabolic, and neurological morbidity. Recent evidence indicates that the oxidative stress and inflammation caused by intermittent hypoxia play a central role in the pathophysiological consequences of OSA. This review aims to summarize the mechanistic links between OSA and oxidative stress, biomarkers, clinical implications, and treatment approaches. Future research directions are also discussed in light of emerging data from human and animal studies. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Turkish Sleep Medicine / Türk Uyku Tıbbı Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Öztürk%2C+Mustafa+Murat%22">Öztürk, Mustafa Murat</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="DE" term="%22Sleep+apnea+syndrome+treatment%22">Sleep apnea syndrome treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Superoxide+dismutase%22">Superoxide dismutase</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolic+disorders%22">Metabolic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Mitochondria%22">Mitochondria</searchLink><br /><searchLink fieldCode="DE" term="%22Adenosine+triphosphate%22">Adenosine triphosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+obstructions%22">Respiratory obstructions</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+diseases+risk+factors%22">Cardiovascular diseases risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+nitrogen+species%22">Reactive nitrogen species</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+apnea+syndromes%22">Sleep apnea syndromes</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Hypoxemia%22">Hypoxemia</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
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  Data: Obstructive sleep apnea (OSA) syndrome is an increasingly prevalent sleep disorder characterized by recurrent upper airway obstructions and associated intermittent episodes of hypoxia. OSA is associated with cardiovascular, metabolic, and neurological morbidity. Recent evidence indicates that the oxidative stress and inflammation caused by intermittent hypoxia play a central role in the pathophysiological consequences of OSA. This review aims to summarize the mechanistic links between OSA and oxidative stress, biomarkers, clinical implications, and treatment approaches. Future research directions are also discussed in light of emerging data from human and animal studies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Journal of Turkish Sleep Medicine / Türk Uyku Tıbbı Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.4274/jtsm.galenos.2026.25349
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 1
    Subjects:
      – SubjectFull: Sleep apnea syndrome treatment
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Superoxide dismutase
        Type: general
      – SubjectFull: Metabolic disorders
        Type: general
      – SubjectFull: Mitochondria
        Type: general
      – SubjectFull: Adenosine triphosphate
        Type: general
      – SubjectFull: Oxidative stress
        Type: general
      – SubjectFull: Respiratory obstructions
        Type: general
      – SubjectFull: Cardiovascular diseases risk factors
        Type: general
      – SubjectFull: Reactive oxygen species
        Type: general
      – SubjectFull: Reactive nitrogen species
        Type: general
      – SubjectFull: Neurological disorders
        Type: general
      – SubjectFull: Sleep apnea syndromes
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Hypoxemia
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
      – SubjectFull: Disease complications
        Type: general
    Titles:
      – TitleFull: The Central Role of Oxidative Stress in the Pathogenesis of Obstructive Sleep Apnea Syndrome: Mechanisms, Biomarkers, and Clinical Implications.
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            NameFull: Öztürk, Mustafa Murat
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          Dates:
            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
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              Value: 21481504
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              Value: 13
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              Value: 2
          Titles:
            – TitleFull: Journal of Turkish Sleep Medicine / Türk Uyku Tıbbı Dergisi
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