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Admission Net Water Uptake Predicts Short‐Term Functional Outcomes After Endovascular Therapy in Anterior Circulation Large Vessel Occlusion Stroke.

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Title: Admission Net Water Uptake Predicts Short‐Term Functional Outcomes After Endovascular Therapy in Anterior Circulation Large Vessel Occlusion Stroke.
Authors: Li, Junying (AUTHOR), Kuang, Min (AUTHOR), Zhong, Xuemin (AUTHOR), Lu, Zhongjiao (AUTHOR), Gou, Jing (AUTHOR), Zhou, Wen (AUTHOR), Li, Yanhui (AUTHOR), He, Lanying (AUTHOR), Wang, Jian (AUTHOR), Chauhan, Anjali (AUTHOR)
Source: Acta Neurologica Scandinavica. 6/24/2026, Vol. 2026, p1-10. 10p.
Subjects: Ischemic stroke, Computed tomography, Biomarkers, Arterial occlusions, Functional status, Endovascular surgery
Abstract: Background and Purpose: Net water uptake (NWU) on noncontrast computed tomography (NCCT) has emerged as a potential imaging biomarker for infarct age and tissue viability in acute ischemic stroke (AIS). This study is aimed at investigating the association between NWU and short‐term clinical outcomes in AIS patients treated with endovascular therapy (EVT). Methods: In this retrospective single‐center study, 193 AIS patients with large vessel occlusion (LVO) who underwent EVT at Chengdu Second People′s Hospital between January 2021 and March 2025 were included. NWU was quantified using automated segmentation of ischemic lesions on NCCT. Functional outcomes were assessed by the modified Rankin Scale (mRS) at 90 days, with good functional outcome defined as mRS ≤ 2. Multivariable logistic regression and receiver operating characteristic (ROC) analyses were used to assess the predictive value of NWU. Results: Among the 193 patients (mean age: 72.88 ± 12.45 years; 92 males), 37.82% achieved good functional outcomes at 90 days. Higher NWU values were significantly associated with poor functional outcomes (median NWU: 8.7% vs. 5.2%, p = 0.001). NWU was independently associated with unfavorable outcome (OR = 1.064; 95% CI, 1.003–1.129; p = 0.039). ROC analysis showed that NWU had moderate predictive accuracy (AUC = 0.645), which improved when combined with admission NIHSS (AUC = 0.802). NWU was also significantly associated with 90‐day mortality or intracranial hemorrhage. Conclusion: Admission CT‐derived NWU shows promise as a predictive marker for outcomes in patients with anterior circulation LVO stroke undergoing EVT. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Label: Title
  Group: Ti
  Data: Admission Net Water Uptake Predicts Short‐Term Functional Outcomes After Endovascular Therapy in Anterior Circulation Large Vessel Occlusion Stroke.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Junying%22">Li, Junying</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kuang%2C+Min%22">Kuang, Min</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhong%2C+Xuemin%22">Zhong, Xuemin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Zhongjiao%22">Lu, Zhongjiao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gou%2C+Jing%22">Gou, Jing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Wen%22">Zhou, Wen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yanhui%22">Li, Yanhui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22He%2C+Lanying%22">He, Lanying</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jian%22">Wang, Jian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chauhan%2C+Anjali%22">Chauhan, Anjali</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 6/24/2026, Vol. 2026, p1-10. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Ischemic+stroke%22">Ischemic stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Arterial+occlusions%22">Arterial occlusions</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+status%22">Functional status</searchLink><br /><searchLink fieldCode="DE" term="%22Endovascular+surgery%22">Endovascular surgery</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and Purpose: Net water uptake (NWU) on noncontrast computed tomography (NCCT) has emerged as a potential imaging biomarker for infarct age and tissue viability in acute ischemic stroke (AIS). This study is aimed at investigating the association between NWU and short‐term clinical outcomes in AIS patients treated with endovascular therapy (EVT). Methods: In this retrospective single‐center study, 193 AIS patients with large vessel occlusion (LVO) who underwent EVT at Chengdu Second People′s Hospital between January 2021 and March 2025 were included. NWU was quantified using automated segmentation of ischemic lesions on NCCT. Functional outcomes were assessed by the modified Rankin Scale (mRS) at 90 days, with good functional outcome defined as mRS ≤ 2. Multivariable logistic regression and receiver operating characteristic (ROC) analyses were used to assess the predictive value of NWU. Results: Among the 193 patients (mean age: 72.88 ± 12.45 years; 92 males), 37.82% achieved good functional outcomes at 90 days. Higher NWU values were significantly associated with poor functional outcomes (median NWU: 8.7% vs. 5.2%, p = 0.001). NWU was independently associated with unfavorable outcome (OR = 1.064; 95% CI, 1.003–1.129; p = 0.039). ROC analysis showed that NWU had moderate predictive accuracy (AUC = 0.645), which improved when combined with admission NIHSS (AUC = 0.802). NWU was also significantly associated with 90‐day mortality or intracranial hemorrhage. Conclusion: Admission CT‐derived NWU shows promise as a predictive marker for outcomes in patients with anterior circulation LVO stroke undergoing EVT. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/ane/7000745
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        Text: English
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        PageCount: 10
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      – SubjectFull: Ischemic stroke
        Type: general
      – SubjectFull: Computed tomography
        Type: general
      – SubjectFull: Biomarkers
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      – SubjectFull: Arterial occlusions
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      – SubjectFull: Functional status
        Type: general
      – SubjectFull: Endovascular surgery
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      – TitleFull: Admission Net Water Uptake Predicts Short‐Term Functional Outcomes After Endovascular Therapy in Anterior Circulation Large Vessel Occlusion Stroke.
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              M: 06
              Text: 6/24/2026
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