View in EDS

Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations.

Saved in:
Bibliographic Details
Title: Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations.
Authors: Dickson, Price E. (AUTHOR), Datta, Udita (AUTHOR), Wilcox, Troy D. (AUTHOR), Auth, Ashley A. (AUTHOR), Ball, Robyn L. (AUTHOR), Dunn, Matt (AUTHOR), Fisher, Heidi S. (AUTHOR), Klein, Alyssa (AUTHOR), Leonardo, Michael R. (AUTHOR), Roy, Tyler A. (AUTHOR), Saul, Michael C. (AUTHOR), Bubier, Jason A. (AUTHOR), Gagnon, Leona H. (AUTHOR), Philip, Vivek M. (AUTHOR), Tarantino, Lisa M. (AUTHOR), Jentsch, James D. (AUTHOR), Chesler, Elissa J. (AUTHOR)
Source: Psychopharmacology. Jun2026, Vol. 243 Issue 6, p1513-1528. 16p.
Subjects: Substance abuse, Mice genetics, Human behavior, Operant conditioning, Genetic variation, Phenotypic plasticity, Gender differences (Sociology)
Abstract: Genetic and other predisposing factors can influence the progression from initiation of drug intake to compulsive substance use through distinct biobehavioral processes. Operant cocaine self-administration studies in laboratory mice offer a powerful method to dissect the biology of this progression from initiation, dose-response, extinction, and cued reinstatement in a controlled, tractable system. However, many such studies encompass limited genetic diversity and rarely examine self-administration behaviors beyond the acquisition stage. Here, we study three high-diversity mouse populations – 50 strains from the Collaborative Cross (CC) reference panel, a large sample of Diversity Outbred (J: DO) population and their eight founder strains – to characterize the varied phenotypic manifestation of behaviors across multiple phases of cocaine intravenous self-administration (IVSA) in both sexes. We observed distinct strain differences among the founders and CC strains in all phases of self-administration, with heritability estimates ranging from 0 to 0.585 and many CC and J: DO phenotypic values exceeding the range of founders including the C57BL/6J strain. Sex differences were common across behaviors, some manifesting as main effects, others as strain interactions. Finally, by adopting a multi-stage design, we identified extreme strains for various cocaine intake and response traits. Together, these findings demonstrate the utility of extended self-administration protocols in high-diversity mouse populations and establish feasibility for their use in the discovery and characterization of biological mechanisms of substance use traits and for preclinical studies in relevant, complex mouse models. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 194995504
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Dickson%2C+Price+E%2E%22">Dickson, Price E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Datta%2C+Udita%22">Datta, Udita</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wilcox%2C+Troy+D%2E%22">Wilcox, Troy D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Auth%2C+Ashley+A%2E%22">Auth, Ashley A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ball%2C+Robyn+L%2E%22">Ball, Robyn L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dunn%2C+Matt%22">Dunn, Matt</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fisher%2C+Heidi+S%2E%22">Fisher, Heidi S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Klein%2C+Alyssa%22">Klein, Alyssa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leonardo%2C+Michael+R%2E%22">Leonardo, Michael R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roy%2C+Tyler+A%2E%22">Roy, Tyler A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saul%2C+Michael+C%2E%22">Saul, Michael C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bubier%2C+Jason+A%2E%22">Bubier, Jason A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gagnon%2C+Leona+H%2E%22">Gagnon, Leona H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Philip%2C+Vivek+M%2E%22">Philip, Vivek M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tarantino%2C+Lisa+M%2E%22">Tarantino, Lisa M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jentsch%2C+James+D%2E%22">Jentsch, James D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chesler%2C+Elissa+J%2E%22">Chesler, Elissa J.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jun2026, Vol. 243 Issue 6, p1513-1528. 16p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Substance+abuse%22">Substance abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Mice+genetics%22">Mice genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Human+behavior%22">Human behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Operant+conditioning%22">Operant conditioning</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+variation%22">Genetic variation</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypic+plasticity%22">Phenotypic plasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Gender+differences+%28Sociology%29%22">Gender differences (Sociology)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Genetic and other predisposing factors can influence the progression from initiation of drug intake to compulsive substance use through distinct biobehavioral processes. Operant cocaine self-administration studies in laboratory mice offer a powerful method to dissect the biology of this progression from initiation, dose-response, extinction, and cued reinstatement in a controlled, tractable system. However, many such studies encompass limited genetic diversity and rarely examine self-administration behaviors beyond the acquisition stage. Here, we study three high-diversity mouse populations – 50 strains from the Collaborative Cross (CC) reference panel, a large sample of Diversity Outbred (J: DO) population and their eight founder strains – to characterize the varied phenotypic manifestation of behaviors across multiple phases of cocaine intravenous self-administration (IVSA) in both sexes. We observed distinct strain differences among the founders and CC strains in all phases of self-administration, with heritability estimates ranging from 0 to 0.585 and many CC and J: DO phenotypic values exceeding the range of founders including the C57BL/6J strain. Sex differences were common across behaviors, some manifesting as main effects, others as strain interactions. Finally, by adopting a multi-stage design, we identified extreme strains for various cocaine intake and response traits. Together, these findings demonstrate the utility of extended self-administration protocols in high-diversity mouse populations and establish feasibility for their use in the discovery and characterization of biological mechanisms of substance use traits and for preclinical studies in relevant, complex mouse models. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=194995504
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00213-025-06904-w
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 1513
    Subjects:
      – SubjectFull: Substance abuse
        Type: general
      – SubjectFull: Mice genetics
        Type: general
      – SubjectFull: Human behavior
        Type: general
      – SubjectFull: Operant conditioning
        Type: general
      – SubjectFull: Genetic variation
        Type: general
      – SubjectFull: Phenotypic plasticity
        Type: general
      – SubjectFull: Gender differences (Sociology)
        Type: general
    Titles:
      – TitleFull: Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Dickson, Price E.
      – PersonEntity:
          Name:
            NameFull: Datta, Udita
      – PersonEntity:
          Name:
            NameFull: Wilcox, Troy D.
      – PersonEntity:
          Name:
            NameFull: Auth, Ashley A.
      – PersonEntity:
          Name:
            NameFull: Ball, Robyn L.
      – PersonEntity:
          Name:
            NameFull: Dunn, Matt
      – PersonEntity:
          Name:
            NameFull: Fisher, Heidi S.
      – PersonEntity:
          Name:
            NameFull: Klein, Alyssa
      – PersonEntity:
          Name:
            NameFull: Leonardo, Michael R.
      – PersonEntity:
          Name:
            NameFull: Roy, Tyler A.
      – PersonEntity:
          Name:
            NameFull: Saul, Michael C.
      – PersonEntity:
          Name:
            NameFull: Bubier, Jason A.
      – PersonEntity:
          Name:
            NameFull: Gagnon, Leona H.
      – PersonEntity:
          Name:
            NameFull: Philip, Vivek M.
      – PersonEntity:
          Name:
            NameFull: Tarantino, Lisa M.
      – PersonEntity:
          Name:
            NameFull: Jentsch, James D.
      – PersonEntity:
          Name:
            NameFull: Chesler, Elissa J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 00333158
          Numbering:
            – Type: volume
              Value: 243
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Psychopharmacology
              Type: main
ResultId 1