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Safety and feasibility of implementing gym-based strength training for people with early onset Parkinson's disease: a phase 1 trial.

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Title: Safety and feasibility of implementing gym-based strength training for people with early onset Parkinson's disease: a phase 1 trial.
Authors: Harris, Dale M. (AUTHOR), Thwaites, Claire (AUTHOR), Callisaya, Michele L. (AUTHOR), Mouer, Rachel (AUTHOR), Blazé, Richard (AUTHOR), Clifford, Amanda M. (AUTHOR), Morris, Meg E. (AUTHOR)
Source: Disability & Rehabilitation. Jun2026, Vol. 48 Issue 12, p3760-3771. 12p.
Subjects: Leg physiology, Exercise physiology, Patient compliance, Motor ability, Patient selection, Physical therapy, Patient safety, Research funding, Health status indicators, T-test (Statistics), Data analysis, Physical fitness centers, Evaluation of human services programs, Clinical trials, Human research subjects, Fatigue (Physiology), Parkinson's disease, Descriptive statistics, Resistance training, Longitudinal method, Control groups, Pre-tests & post-tests, Exercise physiologists, Muscle strength, Quality of life, Statistics, Adverse health care events, Data analysis software, Confidence intervals, Patient participation, Nonparametric statistics
Abstract: Purpose: We examined the safety, feasibility, and preliminary outcomes of a gym-based strength training program for people living with early-onset Parkinson's disease (EOPD), implemented by exercise trainers under physiotherapist supervision. Methods: Ten individuals with EOPD (Hoehn and Yahr 1–3) and eight exercise trainers participated. Participants with EOPD completed up to 16 supervised strength training sessions over eight weeks. A train-the-trainer program was used to educate the exercise trainers who were also supervised by physiotherapists with expertise in PD. The trainers were educated on modifying exercises based on the motor and nonmotor symptoms of EOPD. Safety was evaluated by monitoring both minor and major adverse events. Feasibility measures focused on recruitment, retention, attendance and exercise adherence. Secondary outcomes included strength (3RM testing), motor disability (UPDRS-III), and health status (EQ-VAS). Results: The program was safe without adverse events. Recruitment and retention targets were met, with no dropouts. Attendance was 70.6%, and 88.5% of sessions were fully adhered to. Participant abilities varied, especially in strength and motor performance. For those with EOPD, upper limb strength improved. Conclusion: Gym-based progressive resistance strength training is safe and feasible for some individuals with EOPD when supervised by exercise trainers educated in PD and supervised by physiotherapists. IMPLICATIONS FOR REHABILITATION: Progressive resistance strength training can be delivered safely and effectively in community gyms for people with EOPD when trainers receive PD-specific education, sessions are 1:1, and clinician oversight and clear safety policies/protocols are in place. A comprehensive train-the-trainer model (education covering PD symptoms/medications, exercise selection, intensity/volume progressions, environmental risk mitigation) is essential to ensure high-quality, adaptable programming. Participation barriers for people with EOPD (work/caregiving demands, fluctuating motor symptoms, fatigue) require flexible, highly individualised programs with symptom-responsive modifications and scheduling. Future RCTs should set clear selection criteria (people on stable medication and able to attend 2–3 gym sessions/week), recruit via neurologists/PD organisations/community gyms, and monitor long-term adherence using electronic logs and e-reminders. Adopting 6–12-month follow-ups documenting maintenance, reasons for drop-off, and any delayed adverse events would also be valuable. [ABSTRACT FROM AUTHOR]
Copyright of Disability & Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Safety and feasibility of implementing gym-based strength training for people with early onset Parkinson's disease: a phase 1 trial.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: We examined the safety, feasibility, and preliminary outcomes of a gym-based strength training program for people living with early-onset Parkinson's disease (EOPD), implemented by exercise trainers under physiotherapist supervision. Methods: Ten individuals with EOPD (Hoehn and Yahr 1–3) and eight exercise trainers participated. Participants with EOPD completed up to 16 supervised strength training sessions over eight weeks. A train-the-trainer program was used to educate the exercise trainers who were also supervised by physiotherapists with expertise in PD. The trainers were educated on modifying exercises based on the motor and nonmotor symptoms of EOPD. Safety was evaluated by monitoring both minor and major adverse events. Feasibility measures focused on recruitment, retention, attendance and exercise adherence. Secondary outcomes included strength (3RM testing), motor disability (UPDRS-III), and health status (EQ-VAS). Results: The program was safe without adverse events. Recruitment and retention targets were met, with no dropouts. Attendance was 70.6%, and 88.5% of sessions were fully adhered to. Participant abilities varied, especially in strength and motor performance. For those with EOPD, upper limb strength improved. Conclusion: Gym-based progressive resistance strength training is safe and feasible for some individuals with EOPD when supervised by exercise trainers educated in PD and supervised by physiotherapists. IMPLICATIONS FOR REHABILITATION: Progressive resistance strength training can be delivered safely and effectively in community gyms for people with EOPD when trainers receive PD-specific education, sessions are 1:1, and clinician oversight and clear safety policies/protocols are in place. A comprehensive train-the-trainer model (education covering PD symptoms/medications, exercise selection, intensity/volume progressions, environmental risk mitigation) is essential to ensure high-quality, adaptable programming. Participation barriers for people with EOPD (work/caregiving demands, fluctuating motor symptoms, fatigue) require flexible, highly individualised programs with symptom-responsive modifications and scheduling. Future RCTs should set clear selection criteria (people on stable medication and able to attend 2–3 gym sessions/week), recruit via neurologists/PD organisations/community gyms, and monitor long-term adherence using electronic logs and e-reminders. Adopting 6–12-month follow-ups documenting maintenance, reasons for drop-off, and any delayed adverse events would also be valuable. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Disability & Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=195034198
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/09638288.2025.2595898
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 3760
    Subjects:
      – SubjectFull: Leg physiology
        Type: general
      – SubjectFull: Exercise physiology
        Type: general
      – SubjectFull: Patient compliance
        Type: general
      – SubjectFull: Motor ability
        Type: general
      – SubjectFull: Patient selection
        Type: general
      – SubjectFull: Physical therapy
        Type: general
      – SubjectFull: Patient safety
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Health status indicators
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Physical fitness centers
        Type: general
      – SubjectFull: Evaluation of human services programs
        Type: general
      – SubjectFull: Clinical trials
        Type: general
      – SubjectFull: Human research subjects
        Type: general
      – SubjectFull: Fatigue (Physiology)
        Type: general
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Resistance training
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Control groups
        Type: general
      – SubjectFull: Pre-tests & post-tests
        Type: general
      – SubjectFull: Exercise physiologists
        Type: general
      – SubjectFull: Muscle strength
        Type: general
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Adverse health care events
        Type: general
      – SubjectFull: Data analysis software
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      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Patient participation
        Type: general
      – SubjectFull: Nonparametric statistics
        Type: general
    Titles:
      – TitleFull: Safety and feasibility of implementing gym-based strength training for people with early onset Parkinson's disease: a phase 1 trial.
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              Text: Jun2026
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              Y: 2026
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