Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross‐sectional study.
Saved in:
| Title: | Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross‐sectional study. |
|---|---|
| Authors: | Jin, Minxia (AUTHOR), Xia, Adam W.L. (AUTHOR), Chau, Wanda M.W. (AUTHOR), Shi, Nancy M.X.Y. (AUTHOR), Qin, Penny P. (AUTHOR), Zhang, Bella B.B. (AUTHOR), Kan, Rebecca L.D. (AUTHOR), Tang, Alvin H.P. (AUTHOR), Lin, Tim T.Z. (AUTHOR), Wang, Sharie X. (AUTHOR), Chung, Dicky W.S. (AUTHOR), Padberg, Frank (AUTHOR), Kranz, Georg S. (AUTHOR) |
| Source: | Psychiatry & Clinical Neurosciences. Jul2026, Vol. 80 Issue 7, p616-625. 10p. |
| Subjects: | Prefrontal cortex, Transcranial magnetic stimulation, Functional connectivity, Mental depression, Hemodynamics, Near infrared spectroscopy, Neuroplasticity |
| Abstract: | Background: Mounting evidence has indicated that multiple major depressive disorder (MDD) episodes are correlated with brain morphometric changes that confer an increased recurrence risk. Functional abnormalities underlying this recurrent vulnerability remain underexplored. Acute neuroplastic responses to repetitive transcranial magnetic stimulation hold promise to identify such functional alterations. Methods: This study involved 121 adults, including 39 individuals with current MDD, 41 individuals with MDD in remission, and 41 healthy controls. Cross‐sectional changes in hemodynamic responses and functional connectivity induced by a single session of intermittent theta burst stimulation over the left dorsolateral prefrontal cortex (dlPFC) were measured using simultaneous functional near‐infrared spectroscopy and analyzed with linear mixed models. Hierarchical regression examined the relationships between the number of prior depressive episodes and observed functional changes in patient cohorts. Results: Stimulation instantly elevated deoxyhemoglobin levels in the stimulated dlPFC across all participants, with greater increases in patient cohorts versus controls, demonstrating a persistent disease effect regardless of prior episodes or remitted state. Poststimulation increases in oxyhemoglobin concentration were current depression‐dependent and associated with multiple episodes in remitted patients. Prefrontal networks were characterized by a transient reduction in global node degree during stimulation in all groups. Conclusions: Our findings align with clinical and preclinical evidence linking disrupted neurovascular function in the prefrontal cortex to depression pathophysiology. Poststimulation responses in the stimulated dlPFC, reflecting the current state and multiple prior episodes, show potential for aiding in differential diagnosis and indicating depression vulnerability. Longitudinal studies are needed to determine whether such neurological dysfunctions represent disease progression or a vulnerability biomarker. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 195096512 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross‐sectional study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jin%2C+Minxia%22">Jin, Minxia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xia%2C+Adam+W%2EL%2E%22">Xia, Adam W.L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chau%2C+Wanda+M%2EW%2E%22">Chau, Wanda M.W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Nancy+M%2EX%2EY%2E%22">Shi, Nancy M.X.Y.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qin%2C+Penny+P%2E%22">Qin, Penny P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Bella+B%2EB%2E%22">Zhang, Bella B.B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kan%2C+Rebecca+L%2ED%2E%22">Kan, Rebecca L.D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Alvin+H%2EP%2E%22">Tang, Alvin H.P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Tim+T%2EZ%2E%22">Lin, Tim T.Z.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Sharie+X%2E%22">Wang, Sharie X.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung%2C+Dicky+W%2ES%2E%22">Chung, Dicky W.S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Padberg%2C+Frank%22">Padberg, Frank</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kranz%2C+Georg+S%2E%22">Kranz, Georg S.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Jul2026, Vol. 80 Issue 7, p616-625. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Transcranial+magnetic+stimulation%22">Transcranial magnetic stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+connectivity%22">Functional connectivity</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodynamics%22">Hemodynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Near+infrared+spectroscopy%22">Near infrared spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Mounting evidence has indicated that multiple major depressive disorder (MDD) episodes are correlated with brain morphometric changes that confer an increased recurrence risk. Functional abnormalities underlying this recurrent vulnerability remain underexplored. Acute neuroplastic responses to repetitive transcranial magnetic stimulation hold promise to identify such functional alterations. Methods: This study involved 121 adults, including 39 individuals with current MDD, 41 individuals with MDD in remission, and 41 healthy controls. Cross‐sectional changes in hemodynamic responses and functional connectivity induced by a single session of intermittent theta burst stimulation over the left dorsolateral prefrontal cortex (dlPFC) were measured using simultaneous functional near‐infrared spectroscopy and analyzed with linear mixed models. Hierarchical regression examined the relationships between the number of prior depressive episodes and observed functional changes in patient cohorts. Results: Stimulation instantly elevated deoxyhemoglobin levels in the stimulated dlPFC across all participants, with greater increases in patient cohorts versus controls, demonstrating a persistent disease effect regardless of prior episodes or remitted state. Poststimulation increases in oxyhemoglobin concentration were current depression‐dependent and associated with multiple episodes in remitted patients. Prefrontal networks were characterized by a transient reduction in global node degree during stimulation in all groups. Conclusions: Our findings align with clinical and preclinical evidence linking disrupted neurovascular function in the prefrontal cortex to depression pathophysiology. Poststimulation responses in the stimulated dlPFC, reflecting the current state and multiple prior episodes, show potential for aiding in differential diagnosis and indicating depression vulnerability. Longitudinal studies are needed to determine whether such neurological dysfunctions represent disease progression or a vulnerability biomarker. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=195096512 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/pcn.70066 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 616 Subjects: – SubjectFull: Prefrontal cortex Type: general – SubjectFull: Transcranial magnetic stimulation Type: general – SubjectFull: Functional connectivity Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Hemodynamics Type: general – SubjectFull: Near infrared spectroscopy Type: general – SubjectFull: Neuroplasticity Type: general Titles: – TitleFull: Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross‐sectional study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jin, Minxia – PersonEntity: Name: NameFull: Xia, Adam W.L. – PersonEntity: Name: NameFull: Chau, Wanda M.W. – PersonEntity: Name: NameFull: Shi, Nancy M.X.Y. – PersonEntity: Name: NameFull: Qin, Penny P. – PersonEntity: Name: NameFull: Zhang, Bella B.B. – PersonEntity: Name: NameFull: Kan, Rebecca L.D. – PersonEntity: Name: NameFull: Tang, Alvin H.P. – PersonEntity: Name: NameFull: Lin, Tim T.Z. – PersonEntity: Name: NameFull: Wang, Sharie X. – PersonEntity: Name: NameFull: Chung, Dicky W.S. – PersonEntity: Name: NameFull: Padberg, Frank – PersonEntity: Name: NameFull: Kranz, Georg S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 13231316 Numbering: – Type: volume Value: 80 – Type: issue Value: 7 Titles: – TitleFull: Psychiatry & Clinical Neurosciences Type: main |
| ResultId | 1 |
