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Impact of Social Isolation on Inflammatory Bowel Disease Risk and the Mitigating Effect of a Healthy Lifestyle.

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Title: Impact of Social Isolation on Inflammatory Bowel Disease Risk and the Mitigating Effect of a Healthy Lifestyle.
Authors: Chang, Liang (AUTHOR), Zhang, Jie (AUTHOR), Xu, Mengmeng (AUTHOR), Zhang, Miaomiao (AUTHOR), Xu, Wenhui (AUTHOR), Yu, Shuangye (AUTHOR), Ye, Dongqing (AUTHOR), Fang, Xinyu (AUTHOR)
Source: International Journal of Behavioral Medicine. Jun2026, Vol. 33 Issue 3, p357-366. 10p.
Subjects: Lifestyles, Risk assessment, Patient compliance, Crohn's disease, Statistical hypothesis testing, Multiple regression analysis, Questionnaires, Descriptive statistics, Multivariate analysis, Ulcerative colitis, Chi-squared test, Inflammatory bowel diseases, Longitudinal method, Uk Biobank Ltd., Health behavior, Analysis of variance, Confidence intervals, Data analysis software, Social isolation, Proportional hazards models, Disease risk factors
Geographic Terms: United Kingdom
Abstract: Background: We aimed to evaluate the association of social isolation with incident inflammatory bowel disease (IBD) risk, as well as to investigate whether and to what degree a healthy lifestyle attenuates IBD risk linked to social isolation. Methods: This UK Biobank cohort study included 429,843 participants without a prior diagnosis of IBD. Social isolation was assessed by three dimensions: the frequency of contact with family or friends, the frequency of engagement in leisure or social activities, and the number of family members. A healthy lifestyle considered included five factors: never smoking, a healthy diet, regular physical activity, an adequate body mass index, and sleep duration. We used multivariable Cox proportional hazards regression models to test the association. Stratified and joint analyses were used to further examine the role of a healthy lifestyle. Results: During a median follow-up period of 13.3 years, 2762 IBD cases were identified, including 956 Crohn's disease (CD) and 1806 ulcerative colitis (UC) cases. Social isolation (most isolated vs least isolated) was associated with an increased risk of IBD (hazard ratio (HR) = 1.28, 95%CI 1.13–1.45), UC (HR = 1.23, 95%CI 1.05–1.43), and CD (HR = 1.34, 95%CI 1.08–1.66). Among the most isolated participants, adhering to a favorable lifestyle decreased the risk of IBD (HR = 0.53, 95%CI 0.36–0.78) and CD (HR = 0.31, 95%CI 0.14–0.69), but not UC. Conclusions: Social isolation is associated with a higher risk of IBD and its subtypes. However, adhering to a healthy lifestyle substantially attenuates IBD and CD risks linked to social isolation. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Behavioral Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Impact of Social Isolation on Inflammatory Bowel Disease Risk and the Mitigating Effect of a Healthy Lifestyle.
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  Data: <searchLink fieldCode="AR" term="%22Chang%2C+Liang%22">Chang, Liang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jie%22">Zhang, Jie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Mengmeng%22">Xu, Mengmeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Miaomiao%22">Zhang, Miaomiao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Wenhui%22">Xu, Wenhui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu%2C+Shuangye%22">Yu, Shuangye</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ye%2C+Dongqing%22">Ye, Dongqing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fang%2C+Xinyu%22">Fang, Xinyu</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Behavioral+Medicine%22">International Journal of Behavioral Medicine</searchLink>. Jun2026, Vol. 33 Issue 3, p357-366. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Lifestyles%22">Lifestyles</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22Crohn's+disease%22">Crohn's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+hypothesis+testing%22">Statistical hypothesis testing</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Ulcerative+colitis%22">Ulcerative colitis</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammatory+bowel+diseases%22">Inflammatory bowel diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Uk+Biobank+Ltd%2E%22">Uk Biobank Ltd.</searchLink><br /><searchLink fieldCode="DE" term="%22Health+behavior%22">Health behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Social+isolation%22">Social isolation</searchLink><br /><searchLink fieldCode="DE" term="%22Proportional+hazards+models%22">Proportional hazards models</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22United+Kingdom%22">United Kingdom</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: We aimed to evaluate the association of social isolation with incident inflammatory bowel disease (IBD) risk, as well as to investigate whether and to what degree a healthy lifestyle attenuates IBD risk linked to social isolation. Methods: This UK Biobank cohort study included 429,843 participants without a prior diagnosis of IBD. Social isolation was assessed by three dimensions: the frequency of contact with family or friends, the frequency of engagement in leisure or social activities, and the number of family members. A healthy lifestyle considered included five factors: never smoking, a healthy diet, regular physical activity, an adequate body mass index, and sleep duration. We used multivariable Cox proportional hazards regression models to test the association. Stratified and joint analyses were used to further examine the role of a healthy lifestyle. Results: During a median follow-up period of 13.3 years, 2762 IBD cases were identified, including 956 Crohn's disease (CD) and 1806 ulcerative colitis (UC) cases. Social isolation (most isolated vs least isolated) was associated with an increased risk of IBD (hazard ratio (HR) = 1.28, 95%CI 1.13–1.45), UC (HR = 1.23, 95%CI 1.05–1.43), and CD (HR = 1.34, 95%CI 1.08–1.66). Among the most isolated participants, adhering to a favorable lifestyle decreased the risk of IBD (HR = 0.53, 95%CI 0.36–0.78) and CD (HR = 0.31, 95%CI 0.14–0.69), but not UC. Conclusions: Social isolation is associated with a higher risk of IBD and its subtypes. However, adhering to a healthy lifestyle substantially attenuates IBD and CD risks linked to social isolation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Behavioral Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s12529-025-10373-y
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      – Code: eng
        Text: English
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        StartPage: 357
    Subjects:
      – SubjectFull: Lifestyles
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Patient compliance
        Type: general
      – SubjectFull: Crohn's disease
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      – SubjectFull: Statistical hypothesis testing
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      – SubjectFull: Multiple regression analysis
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      – SubjectFull: Questionnaires
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      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Ulcerative colitis
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Inflammatory bowel diseases
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      – SubjectFull: Longitudinal method
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      – SubjectFull: Uk Biobank Ltd.
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      – SubjectFull: Health behavior
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      – SubjectFull: Analysis of variance
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      – SubjectFull: Confidence intervals
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      – SubjectFull: Social isolation
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              Text: Jun2026
              Type: published
              Y: 2026
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