Optimizing Health for Canadian Youth at Clinical High Risk for Psychosis: A Feasibility Study: Optimiser la santé des jeunes Canadiens présentant un risque clinique élevé de psychose : Une étude de faisabilité.
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| Title: | Optimizing Health for Canadian Youth at Clinical High Risk for Psychosis: A Feasibility Study: Optimiser la santé des jeunes Canadiens présentant un risque clinique élevé de psychose : Une étude de faisabilité. |
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| Authors: | Lu, Yun (AUTHOR), Todesco, Beatrice (AUTHOR), Hawke, Lisa D. (AUTHOR), Kozloff, Nicole (AUTHOR), Strudwick, Gillian (NURSE), Kiang, Michael (AUTHOR), Wang, Wei (AUTHOR), Castle, David (AUTHOR), Foussias, George (AUTHOR), Husain, Muhammad Omair (AUTHOR) |
| Source: | Canadian Journal of Psychiatry. Aug2026, Vol. 71 Issue 8, p623-633. 11p. |
| Subjects: | Youth health, Feasibility studies, Clinical trials, Psychoses, Psychological resilience, Psychotherapy, Functional status |
| Abstract (English): | Objective: We adapted and evaluated a transdiagnostic psychosocial intervention, the Optimal Health Program (OHP), to meet the unique mental health needs of youth at clinical high risk for psychosis (CHR). This study aimed to establish the acceptability of OHP for CHR (OHP-CHR), the feasibility of conducting a confirmatory clinical trial, and the preliminary efficacy of the intervention in improving clinical and functional outcomes. Methods: In this single-arm clinical trial, youth aged 16–29 years meeting CHR criteria were recruited between September 2023 and August 2024. Nine OHP-CHR sessions were delivered over 12 weeks. Acceptability of the intervention was assessed through session attendance rates and the Client Satisfaction Questionnaire (CSQ-8). Feasibility of conducting a confirmatory clinical trial was informed by recruitment, retention, adherence, intervention fidelity, and completion of the outcome schedule. Psychiatric symptoms, resilience, and functioning were assessed at baseline and after 12 weeks. Results: Acceptability of OHP-CHR was demonstrated by high session attendance (n = 26; 86.7% attended all nine sessions) and participant satisfaction scores (CSQ-8: mean = 28.35, SD = 3.68). Feasibility of conducting a confirmatory clinical trial was supported by strong recruitment over 12 months (n = 30; rate of 2–3/month) high retention (n = 26; 86.7% at 12 weeks), intervention fidelity, and ease of completing the clinical assessment schedule. Preliminary indicators of clinical efficacy were demonstrated by a decrease in psychiatric symptoms, improvement in resilience, and enhanced functioning. Conclusions: OHP-CHR is a promising psychosocial intervention co-designed by CHR youth. Our data support the acceptability of the intervention, the feasibility of conducting a confirmatory clinical trial, and preliminary evidence of efficacy in improving clinical and functional outcomes. Trial is registered at ClinicalTrials.gov NCT05757128. Plain Language Summary Title: Testing a well-being and self-efficacy programme for Canadian youth at risk for psychosis Plain Language Summary: Objective: We adapted and tested a mental health programme called the Optimal Health Program (OHP) to better support youth who are at clinical high risk for psychosis (CHR). The goal of this study was to see if the adapted version, called OHP-CHR, was acceptable to young people, whether it would be possible to run a larger clinical trial in the future, and whether the programme could help improve mental health and daily functioning. Methods: We invited youth aged 16 to 29 who met CHR criteria to take part between September 2023 and August 2024. Participants attended nine OHP-CHR sessions over 12 weeks. We looked at how many sessions people attended and how satisfied they were to understand if the programme was acceptable. To see if a larger study would be feasible, we tracked recruitment, retention, session attendance, programme delivery, and completion of assessments. We measured psychiatric symptoms, resilience, and functioning before and after the programme. Results: The programme was well accepted. We successfully recruited 30 participants over 12 months and retained 87% through the end of the study. Most participants (87%) attended all sessions and reported high satisfaction. The programme was delivered as planned, and participants found the assessments easy to complete. After completing OHP-CHR, participants showed fewer symptoms, greater resilience, and better functioning. Conclusions: OHP-CHR is a promising mental health programme developed with input from CHR youth. Our findings show that young people find it acceptable and engaging, and that a larger clinical trial would be feasible. [ABSTRACT FROM AUTHOR] |
| Abstract (French): | Nous avons adapté et évalué une intervention psychosociale transdiagnostique, l'Optimal Health Program (programme OHP), pour répondre aux besoins uniques en santé mentale des jeunes présentant un risque clinique élevé de psychose. Cette étude visait à établir l'acceptabilité du programme OHP pour les jeunes présentant un risque clinique élevé de psychose, la faisabilité de l'essai clinique de confirmation et l'efficacité préliminaire de l'intervention sur le plan de l'amélioration des résultats cliniques et fonctionnels. Dans cet essai clinique à un seul groupe, des jeunes de 16 à 29 ans répondant aux critères de risque clinique élevé de psychose ont été recrutés entre septembre 2023 et août 2024. Neuf séances du programme OHP pour les jeunes présentant un risque clinique élevé de psychose ont été offertes sur une période de 12 semaines. L'acceptabilité de l'intervention a été évaluée au moyen des taux de présence aux séances et du questionnaire sur la satisfaction de la clientèle (CSQ-8). La faisabilité de l'essai clinique de confirmation a été estimée à l'aide de donnée sur le recrutement, la rétention, l'observance, la fidélité à l'intervention et la facilité à respecter le calendrier d'évaluations. Les symptômes psychiatriques, la résilience et le fonctionnement ont été évalués au début de l'étude et après 12 semaines. L'acceptabilité du programme OHP pour les jeunes présentant un risque clinique élevé de psychose a été démontrée par un taux de présence élevé aux séances (n = 26; 86,7% ont assisté aux 9 séances) et par les scores de satisfaction des participants (CSQ-8 : moyenne = 28,35; écart-type = 3,68). La faisabilité de l'essai clinique de confirmation a été appuyée par un recrutement élevé sur 12 mois (n = 30; taux de 2 à 3 par mois), une rétention élevée (n = 26; 86,7% à 12 semaines), la fidélité à l'intervention et la facilité à respecter le calendrier d'évaluations cliniques. Les indicateurs préliminaires de l'efficacité clinique ont été démontrés par une diminution des symptômes psychiatriques, une amélioration de la résilience et un fonctionnement amélioré. Le programme OHP pour les jeunes présentant un risque clinique élevé de psychose est une intervention psychosociale prometteuse conçue conjointement avec des jeunes présentant un risque clinique élevé de psychose. Nos données appuient l'acceptabilité de l'intervention, la faisabilité de l'essai clinique de confirmation et les résultats préliminaires concernant l'efficacité sur le plan de l'amélioration des résultats cliniques et fonctionnels. L'essai est enregistré sur le site ClinicalTrials.gov NCT05757128. [ABSTRACT FROM AUTHOR] |
| Copyright of Canadian Journal of Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 195176460 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Optimizing Health for Canadian Youth at Clinical High Risk for Psychosis: A Feasibility Study: Optimiser la santé des jeunes Canadiens présentant un risque clinique élevé de psychose : Une étude de faisabilité. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lu%2C+Yun%22">Lu, Yun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Todesco%2C+Beatrice%22">Todesco, Beatrice</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hawke%2C+Lisa+D%2E%22">Hawke, Lisa D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kozloff%2C+Nicole%22">Kozloff, Nicole</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Strudwick%2C+Gillian%22">Strudwick, Gillian</searchLink> (NURSE)<br /><searchLink fieldCode="AR" term="%22Kiang%2C+Michael%22">Kiang, Michael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Wei%22">Wang, Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Castle%2C+David%22">Castle, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Foussias%2C+George%22">Foussias, George</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Husain%2C+Muhammad+Omair%22">Husain, Muhammad Omair</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Canadian+Journal+of+Psychiatry%22">Canadian Journal of Psychiatry</searchLink>. Aug2026, Vol. 71 Issue 8, p623-633. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Youth+health%22">Youth health</searchLink><br /><searchLink fieldCode="DE" term="%22Feasibility+studies%22">Feasibility studies</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+resilience%22">Psychological resilience</searchLink><br /><searchLink fieldCode="DE" term="%22Psychotherapy%22">Psychotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+status%22">Functional status</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Objective: We adapted and evaluated a transdiagnostic psychosocial intervention, the Optimal Health Program (OHP), to meet the unique mental health needs of youth at clinical high risk for psychosis (CHR). This study aimed to establish the acceptability of OHP for CHR (OHP-CHR), the feasibility of conducting a confirmatory clinical trial, and the preliminary efficacy of the intervention in improving clinical and functional outcomes. Methods: In this single-arm clinical trial, youth aged 16–29 years meeting CHR criteria were recruited between September 2023 and August 2024. Nine OHP-CHR sessions were delivered over 12 weeks. Acceptability of the intervention was assessed through session attendance rates and the Client Satisfaction Questionnaire (CSQ-8). Feasibility of conducting a confirmatory clinical trial was informed by recruitment, retention, adherence, intervention fidelity, and completion of the outcome schedule. Psychiatric symptoms, resilience, and functioning were assessed at baseline and after 12 weeks. Results: Acceptability of OHP-CHR was demonstrated by high session attendance (n = 26; 86.7% attended all nine sessions) and participant satisfaction scores (CSQ-8: mean = 28.35, SD = 3.68). Feasibility of conducting a confirmatory clinical trial was supported by strong recruitment over 12 months (n = 30; rate of 2–3/month) high retention (n = 26; 86.7% at 12 weeks), intervention fidelity, and ease of completing the clinical assessment schedule. Preliminary indicators of clinical efficacy were demonstrated by a decrease in psychiatric symptoms, improvement in resilience, and enhanced functioning. Conclusions: OHP-CHR is a promising psychosocial intervention co-designed by CHR youth. Our data support the acceptability of the intervention, the feasibility of conducting a confirmatory clinical trial, and preliminary evidence of efficacy in improving clinical and functional outcomes. Trial is registered at ClinicalTrials.gov NCT05757128. Plain Language Summary Title: Testing a well-being and self-efficacy programme for Canadian youth at risk for psychosis Plain Language Summary: Objective: We adapted and tested a mental health programme called the Optimal Health Program (OHP) to better support youth who are at clinical high risk for psychosis (CHR). The goal of this study was to see if the adapted version, called OHP-CHR, was acceptable to young people, whether it would be possible to run a larger clinical trial in the future, and whether the programme could help improve mental health and daily functioning. Methods: We invited youth aged 16 to 29 who met CHR criteria to take part between September 2023 and August 2024. Participants attended nine OHP-CHR sessions over 12 weeks. We looked at how many sessions people attended and how satisfied they were to understand if the programme was acceptable. To see if a larger study would be feasible, we tracked recruitment, retention, session attendance, programme delivery, and completion of assessments. We measured psychiatric symptoms, resilience, and functioning before and after the programme. Results: The programme was well accepted. We successfully recruited 30 participants over 12 months and retained 87% through the end of the study. Most participants (87%) attended all sessions and reported high satisfaction. The programme was delivered as planned, and participants found the assessments easy to complete. After completing OHP-CHR, participants showed fewer symptoms, greater resilience, and better functioning. Conclusions: OHP-CHR is a promising mental health programme developed with input from CHR youth. Our findings show that young people find it acceptable and engaging, and that a larger clinical trial would be feasible. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (French) Group: Ab Data: Nous avons adapté et évalué une intervention psychosociale transdiagnostique, l'Optimal Health Program (programme OHP), pour répondre aux besoins uniques en santé mentale des jeunes présentant un risque clinique élevé de psychose. Cette étude visait à établir l'acceptabilité du programme OHP pour les jeunes présentant un risque clinique élevé de psychose, la faisabilité de l'essai clinique de confirmation et l'efficacité préliminaire de l'intervention sur le plan de l'amélioration des résultats cliniques et fonctionnels. Dans cet essai clinique à un seul groupe, des jeunes de 16 à 29 ans répondant aux critères de risque clinique élevé de psychose ont été recrutés entre septembre 2023 et août 2024. Neuf séances du programme OHP pour les jeunes présentant un risque clinique élevé de psychose ont été offertes sur une période de 12 semaines. L'acceptabilité de l'intervention a été évaluée au moyen des taux de présence aux séances et du questionnaire sur la satisfaction de la clientèle (CSQ-8). La faisabilité de l'essai clinique de confirmation a été estimée à l'aide de donnée sur le recrutement, la rétention, l'observance, la fidélité à l'intervention et la facilité à respecter le calendrier d'évaluations. Les symptômes psychiatriques, la résilience et le fonctionnement ont été évalués au début de l'étude et après 12 semaines. L'acceptabilité du programme OHP pour les jeunes présentant un risque clinique élevé de psychose a été démontrée par un taux de présence élevé aux séances (n = 26; 86,7% ont assisté aux 9 séances) et par les scores de satisfaction des participants (CSQ-8 : moyenne = 28,35; écart-type = 3,68). La faisabilité de l'essai clinique de confirmation a été appuyée par un recrutement élevé sur 12 mois (n = 30; taux de 2 à 3 par mois), une rétention élevée (n = 26; 86,7% à 12 semaines), la fidélité à l'intervention et la facilité à respecter le calendrier d'évaluations cliniques. Les indicateurs préliminaires de l'efficacité clinique ont été démontrés par une diminution des symptômes psychiatriques, une amélioration de la résilience et un fonctionnement amélioré. Le programme OHP pour les jeunes présentant un risque clinique élevé de psychose est une intervention psychosociale prometteuse conçue conjointement avec des jeunes présentant un risque clinique élevé de psychose. Nos données appuient l'acceptabilité de l'intervention, la faisabilité de l'essai clinique de confirmation et les résultats préliminaires concernant l'efficacité sur le plan de l'amélioration des résultats cliniques et fonctionnels. L'essai est enregistré sur le site ClinicalTrials.gov NCT05757128. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Canadian Journal of Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/07067437261436536 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 623 Subjects: – SubjectFull: Youth health Type: general – SubjectFull: Feasibility studies Type: general – SubjectFull: Clinical trials Type: general – SubjectFull: Psychoses Type: general – SubjectFull: Psychological resilience Type: general – SubjectFull: Psychotherapy Type: general – SubjectFull: Functional status Type: general Titles: – TitleFull: Optimizing Health for Canadian Youth at Clinical High Risk for Psychosis: A Feasibility Study: Optimiser la santé des jeunes Canadiens présentant un risque clinique élevé de psychose : Une étude de faisabilité. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lu, Yun – PersonEntity: Name: NameFull: Todesco, Beatrice – PersonEntity: Name: NameFull: Hawke, Lisa D. – PersonEntity: Name: NameFull: Kozloff, Nicole – PersonEntity: Name: NameFull: Strudwick, Gillian – PersonEntity: Name: NameFull: Kiang, Michael – PersonEntity: Name: NameFull: Wang, Wei – PersonEntity: Name: NameFull: Castle, David – PersonEntity: Name: NameFull: Foussias, George – PersonEntity: Name: NameFull: Husain, Muhammad Omair IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 07067437 Numbering: – Type: volume Value: 71 – Type: issue Value: 8 Titles: – TitleFull: Canadian Journal of Psychiatry Type: main |
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