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Efficacy and Safety of Propofol as a Sole Sedative for fMRI Sedation in Autism Spectrum Disorder Individuals with Low IQ.

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Title: Efficacy and Safety of Propofol as a Sole Sedative for fMRI Sedation in Autism Spectrum Disorder Individuals with Low IQ.
Authors: Wei, Xiong (AUTHOR), Jiawei, Zhang (AUTHOR), Maoyuan, Niu (AUTHOR), Weiyong, Yu (AUTHOR), Zhenbo, Chen (AUTHOR), Hongwei, Bu (AUTHOR), Jianjun, Liu (AUTHOR), Qi, Liu (AUTHOR), Xinyu, Duan (AUTHOR), Jiaerheng, Bulideerqing (AUTHOR), Qiang, Wang (AUTHOR), Hao, Zhang (AUTHOR)
Source: Journal of Autism & Developmental Disorders. Jul2026, Vol. 56 Issue 7, p2545-2556. 12p.
Subjects: Intellect, Pearson correlation (Statistics), Patient safety, T-test (Statistics), Research funding, Autism, Clinical trials, Kruskal-Wallis Test, Fisher exact test, Magnetic resonance imaging, Respiratory obstructions, Respiratory diseases, Mann Whitney U Test, Chi-squared test, Descriptive statistics, Propofol, Intravenous therapy, Longitudinal method, Drug efficacy, Seizures (Medicine), One-way analysis of variance, Asperger's syndrome, Psychological tests, Body movement, Data analysis software, Anesthesia, Time, Hypotension, Pharmacodynamics, Evaluation
Geographic Terms: China
Abstract: Autism spectrum disorder (ASD) is a group of complicated neurodevelopmental disorders. Functional magnetic resonance imaging (fMRI) can help to analyze the aberrant neurological functioning in ASD. However, due to their limited cognitive abilities, ASD individuals with low IQ may face challenges in cooperating during fMRI scanning. Consequently, sedation becomes necessary for them. To analyze and evaluate the sedative efficacy and safety of a single intravenous propofol sedation regimen for ASD individuals with low IQ undergoing fMRI examination. Seventy-seven ASD individuals with low IQ, aged 4 to 23 years, who underwent fMRI examination under propofol sedation, were included. Details of the sedation protocol, evaluation indices for effectiveness such as framewise displacement (FD) and temporal signal-to-noise ratio (tSNR), as well as safety assessment measures including pulse oxygen saturation (SPO2) and blood pressure were collected. Adverse events were also recorded. Data analysis was conducted upon completion of the study. Body movement was observed in 12 patients. The median and quartiles (25th percentile, 75th percentile) of FD was 0.065 (0.057, 0.086) mm, while the tSNR averaged at 89.6 ± 11.4. The image data from sixty-two cases (80.5%) were classified as high quality based on their tSNR surpassing 80. No serious adverse events, such as oxygen desaturation, hypotension, nausea, or vomiting, occurred that necessitated hospitalization. The exclusive propofol intravenous sedation protocol employed in this study demonstrates efficacy and safety for administering fMRI examinations to ASD individuals with low IQ, thereby warranting further investigation and validation towards its adoption in clinical practice. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Efficacy and Safety of Propofol as a Sole Sedative for fMRI Sedation in Autism Spectrum Disorder Individuals with Low IQ.
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Jul2026, Vol. 56 Issue 7, p2545-2556. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Intellect%22">Intellect</searchLink><br /><searchLink fieldCode="DE" term="%22Pearson+correlation+%28Statistics%29%22">Pearson correlation (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+safety%22">Patient safety</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Kruskal-Wallis+Test%22">Kruskal-Wallis Test</searchLink><br /><searchLink fieldCode="DE" term="%22Fisher+exact+test%22">Fisher exact test</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+obstructions%22">Respiratory obstructions</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+diseases%22">Respiratory diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Mann+Whitney+U+Test%22">Mann Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Propofol%22">Propofol</searchLink><br /><searchLink fieldCode="DE" term="%22Intravenous+therapy%22">Intravenous therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+efficacy%22">Drug efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22Seizures+%28Medicine%29%22">Seizures (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22One-way+analysis+of+variance%22">One-way analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Asperger's+syndrome%22">Asperger's syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+tests%22">Psychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Body+movement%22">Body movement</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Anesthesia%22">Anesthesia</searchLink><br /><searchLink fieldCode="DE" term="%22Time%22">Time</searchLink><br /><searchLink fieldCode="DE" term="%22Hypotension%22">Hypotension</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacodynamics%22">Pharmacodynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation%22">Evaluation</searchLink>
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  Label: Abstract
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  Data: Autism spectrum disorder (ASD) is a group of complicated neurodevelopmental disorders. Functional magnetic resonance imaging (fMRI) can help to analyze the aberrant neurological functioning in ASD. However, due to their limited cognitive abilities, ASD individuals with low IQ may face challenges in cooperating during fMRI scanning. Consequently, sedation becomes necessary for them. To analyze and evaluate the sedative efficacy and safety of a single intravenous propofol sedation regimen for ASD individuals with low IQ undergoing fMRI examination. Seventy-seven ASD individuals with low IQ, aged 4 to 23 years, who underwent fMRI examination under propofol sedation, were included. Details of the sedation protocol, evaluation indices for effectiveness such as framewise displacement (FD) and temporal signal-to-noise ratio (tSNR), as well as safety assessment measures including pulse oxygen saturation (SPO2) and blood pressure were collected. Adverse events were also recorded. Data analysis was conducted upon completion of the study. Body movement was observed in 12 patients. The median and quartiles (25th percentile, 75th percentile) of FD was 0.065 (0.057, 0.086) mm, while the tSNR averaged at 89.6 ± 11.4. The image data from sixty-two cases (80.5%) were classified as high quality based on their tSNR surpassing 80. No serious adverse events, such as oxygen desaturation, hypotension, nausea, or vomiting, occurred that necessitated hospitalization. The exclusive propofol intravenous sedation protocol employed in this study demonstrates efficacy and safety for administering fMRI examinations to ASD individuals with low IQ, thereby warranting further investigation and validation towards its adoption in clinical practice. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=195184721
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10803-025-06742-x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 2545
    Subjects:
      – SubjectFull: Intellect
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
        Type: general
      – SubjectFull: Patient safety
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Research funding
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      – SubjectFull: Autism
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      – SubjectFull: Clinical trials
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      – SubjectFull: Kruskal-Wallis Test
        Type: general
      – SubjectFull: Fisher exact test
        Type: general
      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Respiratory obstructions
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      – SubjectFull: Respiratory diseases
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      – SubjectFull: Mann Whitney U Test
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      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Propofol
        Type: general
      – SubjectFull: Intravenous therapy
        Type: general
      – SubjectFull: Longitudinal method
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      – SubjectFull: Drug efficacy
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      – SubjectFull: Seizures (Medicine)
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      – SubjectFull: Asperger's syndrome
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      – SubjectFull: Psychological tests
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      – SubjectFull: Body movement
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      – SubjectFull: Anesthesia
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      – SubjectFull: Time
        Type: general
      – SubjectFull: Hypotension
        Type: general
      – SubjectFull: Pharmacodynamics
        Type: general
      – SubjectFull: Evaluation
        Type: general
      – SubjectFull: China
        Type: general
    Titles:
      – TitleFull: Efficacy and Safety of Propofol as a Sole Sedative for fMRI Sedation in Autism Spectrum Disorder Individuals with Low IQ.
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              Text: Jul2026
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              Y: 2026
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