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Progenitor Types in the Human Cortex in Normal Development and Glioblastoma.

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Title: Progenitor Types in the Human Cortex in Normal Development and Glioblastoma.
Authors: Martija, Antoni (AUTHOR), Bhaduri, Aparna (AUTHOR)
Source: Annual Review of Neuroscience. Jul2026, Vol. 49 Issue 1, p19-37. 14p.
Subjects: Progenitor cells, Glioblastoma multiforme, Cell proliferation, Cell differentiation, Tumor microenvironment, Cerebral cortex development, Neural development
Abstract: Human cortical development is dependent upon the structured proliferation and differentiation of progenitors into differentiated cell types. This process is tightly regulated by intrinsic and extrinsic cues, which converge to drive human-specific features of the cortex, most notably its expanded size and complexity. On the other hand, glioblastoma (GBM), a highly aggressive primary brain tumor, consists of a heterogeneous mix of neurodevelopmental-like cells that lack control of their proliferation and differentiation. These tumor cells exhibit uncontrollable growth and extreme plasticity, driven by somatic mutations, epigenetic rewiring, microenvironmental interactions, and maladaptive responses to therapy. Recent lineage-tracing and fate-mapping experiments have uncovered unconventional lineage relationships in both normal development and GBM, revealing new cell types along with their origins and progeny. We anticipate that neurodevelopmental perspectives will continue to deepen our understanding of GBM heterogeneity and plasticity, which can then inform the development of cell state reprogramming approaches for therapy. [ABSTRACT FROM AUTHOR]
Copyright of Annual Review of Neuroscience is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Progenitor Types in the Human Cortex in Normal Development and Glioblastoma.
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  Data: <searchLink fieldCode="AR" term="%22Martija%2C+Antoni%22">Martija, Antoni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bhaduri%2C+Aparna%22">Bhaduri, Aparna</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Annual+Review+of+Neuroscience%22">Annual Review of Neuroscience</searchLink>. Jul2026, Vol. 49 Issue 1, p19-37. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Progenitor+cells%22">Progenitor cells</searchLink><br /><searchLink fieldCode="DE" term="%22Glioblastoma+multiforme%22">Glioblastoma multiforme</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+proliferation%22">Cell proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+differentiation%22">Cell differentiation</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+microenvironment%22">Tumor microenvironment</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+cortex+development%22">Cerebral cortex development</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink>
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  Data: Human cortical development is dependent upon the structured proliferation and differentiation of progenitors into differentiated cell types. This process is tightly regulated by intrinsic and extrinsic cues, which converge to drive human-specific features of the cortex, most notably its expanded size and complexity. On the other hand, glioblastoma (GBM), a highly aggressive primary brain tumor, consists of a heterogeneous mix of neurodevelopmental-like cells that lack control of their proliferation and differentiation. These tumor cells exhibit uncontrollable growth and extreme plasticity, driven by somatic mutations, epigenetic rewiring, microenvironmental interactions, and maladaptive responses to therapy. Recent lineage-tracing and fate-mapping experiments have uncovered unconventional lineage relationships in both normal development and GBM, revealing new cell types along with their origins and progeny. We anticipate that neurodevelopmental perspectives will continue to deepen our understanding of GBM heterogeneity and plasticity, which can then inform the development of cell state reprogramming approaches for therapy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Annual Review of Neuroscience is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1146/annurev-neuro-102124-032845
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 14
        StartPage: 19
    Subjects:
      – SubjectFull: Progenitor cells
        Type: general
      – SubjectFull: Glioblastoma multiforme
        Type: general
      – SubjectFull: Cell proliferation
        Type: general
      – SubjectFull: Cell differentiation
        Type: general
      – SubjectFull: Tumor microenvironment
        Type: general
      – SubjectFull: Cerebral cortex development
        Type: general
      – SubjectFull: Neural development
        Type: general
    Titles:
      – TitleFull: Progenitor Types in the Human Cortex in Normal Development and Glioblastoma.
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              M: 07
              Text: Jul2026
              Type: published
              Y: 2026
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