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Roles of Thalamocortical Axons in Cerebral Cortical Development.

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Title: Roles of Thalamocortical Axons in Cerebral Cortical Development.
Authors: Nakagawa, Yasushi (AUTHOR)
Source: Annual Review of Neuroscience. Jul2026, Vol. 49 Issue 1, p125-141. 14p.
Subjects: Cerebral cortex development, Thalamocortical system, Neuronal differentiation, Progenitor cells, Sensorimotor integration, Neocortex
Abstract: In the adult mammalian brain, thalamocortical input supports key cortical functions by conveying ascending information from subcortical sensory and motor centers and linking different cortical areas. Studies in the 1980s revealed that these afferent projections are also critical for building the mature neocortex, which is composed of six layers and dozens of anatomically and functionally distinct areas. Recent studies have begun to provide a comprehensive view of cortical development, encompassing early regionalization of immature cortical tissue, distinct behaviors of various progenitor cell types, fate specification of neurons forming the six layers, and morphological and functional maturation of each neuronal type leading to the formation of distinct areas. Many of these processes are now known to be influenced by thalamocortical input. This review highlights the historical contexts in which the roles of the thalamus were uncovered, drawing on evidence from a wide range of organisms, cortical regions, and cell types. [ABSTRACT FROM AUTHOR]
Copyright of Annual Review of Neuroscience is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Nakagawa%2C+Yasushi%22">Nakagawa, Yasushi</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="DE" term="%22Cerebral+cortex+development%22">Cerebral cortex development</searchLink><br /><searchLink fieldCode="DE" term="%22Thalamocortical+system%22">Thalamocortical system</searchLink><br /><searchLink fieldCode="DE" term="%22Neuronal+differentiation%22">Neuronal differentiation</searchLink><br /><searchLink fieldCode="DE" term="%22Progenitor+cells%22">Progenitor cells</searchLink><br /><searchLink fieldCode="DE" term="%22Sensorimotor+integration%22">Sensorimotor integration</searchLink><br /><searchLink fieldCode="DE" term="%22Neocortex%22">Neocortex</searchLink>
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  Data: In the adult mammalian brain, thalamocortical input supports key cortical functions by conveying ascending information from subcortical sensory and motor centers and linking different cortical areas. Studies in the 1980s revealed that these afferent projections are also critical for building the mature neocortex, which is composed of six layers and dozens of anatomically and functionally distinct areas. Recent studies have begun to provide a comprehensive view of cortical development, encompassing early regionalization of immature cortical tissue, distinct behaviors of various progenitor cell types, fate specification of neurons forming the six layers, and morphological and functional maturation of each neuronal type leading to the formation of distinct areas. Many of these processes are now known to be influenced by thalamocortical input. This review highlights the historical contexts in which the roles of the thalamus were uncovered, drawing on evidence from a wide range of organisms, cortical regions, and cell types. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Annual Review of Neuroscience is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1146/annurev-neuro-102124-033959
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      – Code: eng
        Text: English
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        PageCount: 14
        StartPage: 125
    Subjects:
      – SubjectFull: Cerebral cortex development
        Type: general
      – SubjectFull: Thalamocortical system
        Type: general
      – SubjectFull: Neuronal differentiation
        Type: general
      – SubjectFull: Progenitor cells
        Type: general
      – SubjectFull: Sensorimotor integration
        Type: general
      – SubjectFull: Neocortex
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      – TitleFull: Roles of Thalamocortical Axons in Cerebral Cortical Development.
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              Text: Jul2026
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              Y: 2026
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