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Quantitative electroencephalographic measures during postmalarial epileptogenesis.

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Title: Quantitative electroencephalographic measures during postmalarial epileptogenesis.
Authors: Joshi, Rasesh B. (AUTHOR), Mwanza, Suzanna (AUTHOR), Zaveri, Hitten P. (AUTHOR), Kasolo, Joseph (AUTHOR), Masempela, Angela (AUTHOR), Musakanya, Thelma (AUTHOR), Mwale, Tina (AUTHOR), Nambeye, Violet (AUTHOR), Nyriongo, Rosemary (AUTHOR), Tembo, Ruth A. (AUTHOR), Cortina, Christopher (AUTHOR), Zhang, Bo (AUTHOR), Birbeck, Gretchen L. (AUTHOR), Rotenberg, Alexander (AUTHOR), Patel, Archana A. (AUTHOR)
Source: Epilepsia (Series 4). Jul2026, Vol. 67 Issue 7, p3602-3611. 10p.
Subjects: Electroencephalography, Malaria, Childhood epilepsy, Electrophysiology, Cerebral malaria, Risk assessment
Geographic Terms: Zambia
Abstract: Objective: Severe malaria with neurologic involvement contributes significantly to the global burden of acquired pediatric epilepsy. We studied quantitative electroencephalographic (EEG) measures in postmalarial epileptogenesis. Methods: A total of 186 patients, aged 6 months to 11 years, with confirmed central nervous system malaria were enrolled in a prospective observational study conducted in Chipata, Zambia. EEG data were collected during acute illness for 179 patients. Patients were followed for 12 months postdischarge with EEG and clinical reviews to assess postmalarial epilepsy (PME) outcomes. A total of 155 patients were seen for 1‐month, 144 for 6‐month, and 142 for 12‐month follow‐up. Twenty‐six patients were diagnosed with PME. We examined EEG measures (relative power, magnitude‐squared coherence [MSC], and approximate entropy [ApEn]) to identify differences between patients who developed PME and those who did not. Results: Relative gamma power at admission was significantly greater in the PME group, whereas at 1‐month and 6‐month follow‐up it was greater in the nonepilepsy group. Alpha and beta power increased in both groups over time, suggesting a prolonged process of neurologic recovery, with greater power in both bands observed in the nonepilepsy group at 12‐month follow‐up. ApEn was greater in the nonepilepsy group at admission and 1‐month and 6‐month follow‐up. At admission and 1‐month follow‐up, we observed a significant decrease in beta and gamma MSC in the epilepsy group as compared to the nonepilepsy group. These differences were absent at 6‐month follow‐up but became more prominent again at 12‐month follow‐up. Significance: These and related EEG measures may provide value for risk stratification of patients with severe malaria. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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  Data: Quantitative electroencephalographic measures during postmalarial epileptogenesis.
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  Data: <searchLink fieldCode="AR" term="%22Joshi%2C+Rasesh+B%2E%22">Joshi, Rasesh B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mwanza%2C+Suzanna%22">Mwanza, Suzanna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zaveri%2C+Hitten+P%2E%22">Zaveri, Hitten P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kasolo%2C+Joseph%22">Kasolo, Joseph</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Masempela%2C+Angela%22">Masempela, Angela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Musakanya%2C+Thelma%22">Musakanya, Thelma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mwale%2C+Tina%22">Mwale, Tina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nambeye%2C+Violet%22">Nambeye, Violet</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nyriongo%2C+Rosemary%22">Nyriongo, Rosemary</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tembo%2C+Ruth+A%2E%22">Tembo, Ruth A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cortina%2C+Christopher%22">Cortina, Christopher</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Bo%22">Zhang, Bo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Birbeck%2C+Gretchen+L%2E%22">Birbeck, Gretchen L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rotenberg%2C+Alexander%22">Rotenberg, Alexander</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patel%2C+Archana+A%2E%22">Patel, Archana A.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Jul2026, Vol. 67 Issue 7, p3602-3611. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Electroencephalography%22">Electroencephalography</searchLink><br /><searchLink fieldCode="DE" term="%22Malaria%22">Malaria</searchLink><br /><searchLink fieldCode="DE" term="%22Childhood+epilepsy%22">Childhood epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Electrophysiology%22">Electrophysiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+malaria%22">Cerebral malaria</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink>
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  Data: Objective: Severe malaria with neurologic involvement contributes significantly to the global burden of acquired pediatric epilepsy. We studied quantitative electroencephalographic (EEG) measures in postmalarial epileptogenesis. Methods: A total of 186 patients, aged 6 months to 11 years, with confirmed central nervous system malaria were enrolled in a prospective observational study conducted in Chipata, Zambia. EEG data were collected during acute illness for 179 patients. Patients were followed for 12 months postdischarge with EEG and clinical reviews to assess postmalarial epilepsy (PME) outcomes. A total of 155 patients were seen for 1‐month, 144 for 6‐month, and 142 for 12‐month follow‐up. Twenty‐six patients were diagnosed with PME. We examined EEG measures (relative power, magnitude‐squared coherence [MSC], and approximate entropy [ApEn]) to identify differences between patients who developed PME and those who did not. Results: Relative gamma power at admission was significantly greater in the PME group, whereas at 1‐month and 6‐month follow‐up it was greater in the nonepilepsy group. Alpha and beta power increased in both groups over time, suggesting a prolonged process of neurologic recovery, with greater power in both bands observed in the nonepilepsy group at 12‐month follow‐up. ApEn was greater in the nonepilepsy group at admission and 1‐month and 6‐month follow‐up. At admission and 1‐month follow‐up, we observed a significant decrease in beta and gamma MSC in the epilepsy group as compared to the nonepilepsy group. These differences were absent at 6‐month follow‐up but became more prominent again at 12‐month follow‐up. Significance: These and related EEG measures may provide value for risk stratification of patients with severe malaria. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1002/epi.70257
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 3602
    Subjects:
      – SubjectFull: Electroencephalography
        Type: general
      – SubjectFull: Malaria
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      – SubjectFull: Childhood epilepsy
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      – SubjectFull: Electrophysiology
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      – SubjectFull: Cerebral malaria
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      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Zambia
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      – TitleFull: Quantitative electroencephalographic measures during postmalarial epileptogenesis.
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              Text: Jul2026
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