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Efficacy of Remote Ischemic Conditioning for Moyamoya Disease: A Meta‐Analysis of Randomized Controlled Trials.

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Title: Efficacy of Remote Ischemic Conditioning for Moyamoya Disease: A Meta‐Analysis of Randomized Controlled Trials.
Authors: Zheng, Xiaohong (AUTHOR), Liu, Hongliang (AUTHOR), Zheng, Jing (AUTHOR), Li, Xiaojie (AUTHOR), Zu, Yanmei (AUTHOR), Zhou, Tianqi (AUTHOR), Li, Dongmei (AUTHOR), Liu, Jianmin (AUTHOR), Xu, Li (AUTHOR), Dhoundiyal, Ankit (AUTHOR)
Source: Acta Neurologica Scandinavica. 7/21/2026, Vol. 2026, p1-9. 9p.
Subjects: Moyamoya disease, Ischemic conditioning, Neuroprotective agents, Transient ischemic attack, Evidence synthesis, Randomized controlled trials, Ischemic stroke
Abstract: Introduction: Remote ischemic conditioning (RIC) is a noninvasive, transient procedure that induces brief ischemia and reperfusion. Currently, an assessment of its efficacy in treating moyamoya disease (MMD) remains lacking. This meta‐analysis synthesized data from existing randomized controlled trials (RCTs) to estimate the efficacy of RIC in MMD patients. Methods: Embase, PubMed, Wanfang, Cochrane Library, Web of Science, Scopus, and CNKI were comprehensively searched from database inception to May 8, 2026. The Cochrane risk of bias tool was used to assess the quality of the included RCTs. Statistical analyses were carried out using Review Manager Version 5.4.1. Results: RIC was associated with a lower incidence of ischemic stroke in patients with MMD (n = 228, OR: 0.22, 95% CI: 0.07–0.67, p = 0.008). No significant reduction was observed in the incidence of transient ischemic attacks (TIA) (n = 184, OR: 0.73, 95% CI: 0.36–1.47, p = 0.38), CHS (n = 152, OR: 0.28, 95% CI: 0.07–1.12, p = 0.07), or seizures (n = 152, OR: 0.26, 95% CI: 0.04–1.62, p = 0.15). Conclusion: RIC may have potential neuroprotective effects in patients with MMD, particularly regarding ischemic stroke. However, the current evidence remains limited by small sample sizes, sparse events, and substantial heterogeneity. Further adequately powered multicenter RCTs are required to confirm these findings. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Label: Title
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  Data: Efficacy of Remote Ischemic Conditioning for Moyamoya Disease: A Meta‐Analysis of Randomized Controlled Trials.
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  Data: <searchLink fieldCode="AR" term="%22Zheng%2C+Xiaohong%22">Zheng, Xiaohong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Hongliang%22">Liu, Hongliang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Jing%22">Zheng, Jing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Xiaojie%22">Li, Xiaojie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zu%2C+Yanmei%22">Zu, Yanmei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Tianqi%22">Zhou, Tianqi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Dongmei%22">Li, Dongmei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Jianmin%22">Liu, Jianmin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Li%22">Xu, Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dhoundiyal%2C+Ankit%22">Dhoundiyal, Ankit</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 7/21/2026, Vol. 2026, p1-9. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Moyamoya+disease%22">Moyamoya disease</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemic+conditioning%22">Ischemic conditioning</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroprotective+agents%22">Neuroprotective agents</searchLink><br /><searchLink fieldCode="DE" term="%22Transient+ischemic+attack%22">Transient ischemic attack</searchLink><br /><searchLink fieldCode="DE" term="%22Evidence+synthesis%22">Evidence synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemic+stroke%22">Ischemic stroke</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Remote ischemic conditioning (RIC) is a noninvasive, transient procedure that induces brief ischemia and reperfusion. Currently, an assessment of its efficacy in treating moyamoya disease (MMD) remains lacking. This meta‐analysis synthesized data from existing randomized controlled trials (RCTs) to estimate the efficacy of RIC in MMD patients. Methods: Embase, PubMed, Wanfang, Cochrane Library, Web of Science, Scopus, and CNKI were comprehensively searched from database inception to May 8, 2026. The Cochrane risk of bias tool was used to assess the quality of the included RCTs. Statistical analyses were carried out using Review Manager Version 5.4.1. Results: RIC was associated with a lower incidence of ischemic stroke in patients with MMD (n = 228, OR: 0.22, 95% CI: 0.07–0.67, p = 0.008). No significant reduction was observed in the incidence of transient ischemic attacks (TIA) (n = 184, OR: 0.73, 95% CI: 0.36–1.47, p = 0.38), CHS (n = 152, OR: 0.28, 95% CI: 0.07–1.12, p = 0.07), or seizures (n = 152, OR: 0.26, 95% CI: 0.04–1.62, p = 0.15). Conclusion: RIC may have potential neuroprotective effects in patients with MMD, particularly regarding ischemic stroke. However, the current evidence remains limited by small sample sizes, sparse events, and substantial heterogeneity. Further adequately powered multicenter RCTs are required to confirm these findings. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/ane/4660621
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        Text: English
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      – SubjectFull: Moyamoya disease
        Type: general
      – SubjectFull: Ischemic conditioning
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      – SubjectFull: Neuroprotective agents
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      – SubjectFull: Transient ischemic attack
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      – SubjectFull: Randomized controlled trials
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      – SubjectFull: Ischemic stroke
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      – TitleFull: Efficacy of Remote Ischemic Conditioning for Moyamoya Disease: A Meta‐Analysis of Randomized Controlled Trials.
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              Text: 7/21/2026
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