Verbal and Visuospatial Working Memory Performance During the CO2 Challenge Model of Anxiety.

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Title: Verbal and Visuospatial Working Memory Performance During the CO2 Challenge Model of Anxiety.
Authors: Dunger, Warren (AUTHOR), Edwards, Marc (AUTHOR), Board, Alex (AUTHOR), Garner, Matthew (AUTHOR)
Source: Human Psychopharmacology: Clinical & Experimental. Jul2026, Vol. 41 Issue 4, p1-9. 9p.
Abstract: Objective: Anxiety influences working memory performance, but the effects on clinical neuropsychological assessments of working memory are not well known. Methods: We examined the effect of anxiety, induced using the 7.5% carbon dioxide model of anxiety on standardized clinical neuropsychological tests of working memory and executive function in a single‐blind, placebo‐controlled, randomized, crossover within‐subjects design. Results: The CO2‐challenge reduced spatial working memory performance and verbal working memory performance accuracy when task demands were high. The CO2‐challenge increased effort and reduced processing efficiency across all verbal and spatial working memory tasks. Conclusions: The CO2‐challenge resulted in significant reductions in working memory performance and processing efficiency. These results encourage the routine assessment of anxiety when administering and interpreting neuropsychological measures of working memory function in clinical practice. [ABSTRACT FROM AUTHOR]
Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Verbal and Visuospatial Working Memory Performance During the CO<subscript>2</subscript> Challenge Model of Anxiety.
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  Data: <searchLink fieldCode="AR" term="%22Dunger%2C+Warren%22">Dunger, Warren</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Edwards%2C+Marc%22">Edwards, Marc</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Board%2C+Alex%22">Board, Alex</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garner%2C+Matthew%22">Garner, Matthew</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Jul2026, Vol. 41 Issue 4, p1-9. 9p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Anxiety influences working memory performance, but the effects on clinical neuropsychological assessments of working memory are not well known. Methods: We examined the effect of anxiety, induced using the 7.5% carbon dioxide model of anxiety on standardized clinical neuropsychological tests of working memory and executive function in a single‐blind, placebo‐controlled, randomized, crossover within‐subjects design. Results: The CO2‐challenge reduced spatial working memory performance and verbal working memory performance accuracy when task demands were high. The CO2‐challenge increased effort and reduced processing efficiency across all verbal and spatial working memory tasks. Conclusions: The CO2‐challenge resulted in significant reductions in working memory performance and processing efficiency. These results encourage the routine assessment of anxiety when administering and interpreting neuropsychological measures of working memory function in clinical practice. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/hup.70051
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        Text: English
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            NameFull: Dunger, Warren
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            NameFull: Edwards, Marc
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            NameFull: Board, Alex
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              Text: Jul2026
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              Y: 2026
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