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Prenatal Exposure to Ambient Particulate Matter and Autism Spectrum Disorder in Children, a Case Control Study in France.

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Title: Prenatal Exposure to Ambient Particulate Matter and Autism Spectrum Disorder in Children, a Case Control Study in France.
Authors: Mortamais, Marion (AUTHOR), Ongono, Jeanne Sandrine (AUTHOR), Michelon, Cécile (AUTHOR), Hough, Ian (AUTHOR), Seyve, Emie (AUTHOR), Kloog, Itai (AUTHOR), Zaros, Cécile (AUTHOR), Charles, Marie-Aline (AUTHOR), Lepeule, Johanna (AUTHOR), Baghdadli, Amaria (AUTHOR)
Source: Journal of Autism & Developmental Disorders. Sep2026, Vol. 56 Issue 9, p3713-3725. 13p.
Subjects: Autism risk factors, Air pollution, Risk assessment, Prenatal exposure delayed effects, Research funding, Maternal exposure, Child psychopathology, Logistic regression analysis, Fisher exact test, Descriptive statistics, Mann Whitney U Test, Chi-squared test, Odds ratio, Case-control method, Environmental exposure, Asperger's syndrome, Particulate matter, Confidence intervals, Children
Geographic Terms: France
Abstract: A series of epidemiological studies conducted in the United States have consistently shown an increased risk of autism spectrum disorder (ASD) in children associated with pre- and postnatal exposure to ambient particulate matter (PM). In Europe, studies are scarce and results are inconsistent. We aimed to investigate the association between prenatal exposure to PM and the risk of ASD in France. ASD cases were participants from the ELENA cohort. Controls children from the ELFE cohort were matched by sex, year (± 2) and region of birth. Prenatal exposures to PM10 and to PM2.5 were estimated between 2008 and 2013 using innovative hybrid spatio-temporal models developed for France. Conditional logistic regression models adjusted for birth season, parent's age at the child birth and parental education level were run. We included 125 ASD cases and 500 controls. Prenatal PM2.5 and PM10 median (IQR) concentration estimates were respectively 16.3 (3.9) µg/m3 and 22.9 (6.6) µg/m3 in the whole sample. The conditional logistic regression models showed Odds Ratios (ORs) (Confidence Interval 95%) for ASD risk of 0.72 (0.52–1.01) and 0.84 (0.58–1.22) for an IQR increase in PM2.5 and PM10 prenatal levels, respectively. When restricting population of ASD cases to children born the same year of controls, ORs were 1.79 (0.80–4.01) and 2.23 (0.71–9.04), respectively. Our results did not show that prenatal exposures to PM2.5 and PM10 were associated with the risk of ASD in children in France. Trial Registration Number NCT02625116. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Prenatal Exposure to Ambient Particulate Matter and Autism Spectrum Disorder in Children, a Case Control Study in France.
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  Data: <searchLink fieldCode="AR" term="%22Mortamais%2C+Marion%22">Mortamais, Marion</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ongono%2C+Jeanne+Sandrine%22">Ongono, Jeanne Sandrine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Michelon%2C+Cécile%22">Michelon, Cécile</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hough%2C+Ian%22">Hough, Ian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seyve%2C+Emie%22">Seyve, Emie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kloog%2C+Itai%22">Kloog, Itai</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zaros%2C+Cécile%22">Zaros, Cécile</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Charles%2C+Marie-Aline%22">Charles, Marie-Aline</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lepeule%2C+Johanna%22">Lepeule, Johanna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baghdadli%2C+Amaria%22">Baghdadli, Amaria</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Sep2026, Vol. 56 Issue 9, p3713-3725. 13p.
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  Label: Abstract
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  Data: A series of epidemiological studies conducted in the United States have consistently shown an increased risk of autism spectrum disorder (ASD) in children associated with pre- and postnatal exposure to ambient particulate matter (PM). In Europe, studies are scarce and results are inconsistent. We aimed to investigate the association between prenatal exposure to PM and the risk of ASD in France. ASD cases were participants from the ELENA cohort. Controls children from the ELFE cohort were matched by sex, year (± 2) and region of birth. Prenatal exposures to PM10 and to PM2.5 were estimated between 2008 and 2013 using innovative hybrid spatio-temporal models developed for France. Conditional logistic regression models adjusted for birth season, parent's age at the child birth and parental education level were run. We included 125 ASD cases and 500 controls. Prenatal PM2.5 and PM10 median (IQR) concentration estimates were respectively 16.3 (3.9) µg/m3 and 22.9 (6.6) µg/m3 in the whole sample. The conditional logistic regression models showed Odds Ratios (ORs) (Confidence Interval 95%) for ASD risk of 0.72 (0.52–1.01) and 0.84 (0.58–1.22) for an IQR increase in PM2.5 and PM10 prenatal levels, respectively. When restricting population of ASD cases to children born the same year of controls, ORs were 1.79 (0.80–4.01) and 2.23 (0.71–9.04), respectively. Our results did not show that prenatal exposures to PM2.5 and PM10 were associated with the risk of ASD in children in France. Trial Registration Number NCT02625116. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=195843181
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      – Type: doi
        Value: 10.1007/s10803-025-06795-y
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      – Code: eng
        Text: English
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      – SubjectFull: Autism risk factors
        Type: general
      – SubjectFull: Air pollution
        Type: general
      – SubjectFull: Risk assessment
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      – SubjectFull: Prenatal exposure delayed effects
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      – SubjectFull: Research funding
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      – SubjectFull: Maternal exposure
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      – SubjectFull: Child psychopathology
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      – SubjectFull: Logistic regression analysis
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Mann Whitney U Test
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      – SubjectFull: Chi-squared test
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      – SubjectFull: Asperger's syndrome
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      – SubjectFull: France
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              Text: Sep2026
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