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Clinical and preclinical evidence of sex differences in nicotine-induced enhancement of alcohol self-administration.

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Title: Clinical and preclinical evidence of sex differences in nicotine-induced enhancement of alcohol self-administration.
Authors: Garcia-Rivas, Vernon (AUTHOR), Zakiniaeiz, Yasmin (AUTHOR), Jimenez Chavez, C. Leonardo (AUTHOR), Kohler, Robert J. (AUTHOR), Peltier, MacKenzie R. (AUTHOR), Raval, Nakul R. (AUTHOR), Verplaetse, Terril L. (AUTHOR), Zhou, Hang (AUTHOR), McKee, Sherry A. (AUTHOR)
Source: Psychopharmacology. Jul2026, Vol. 243 Issue 7, p1555-1568. 14p.
Subjects: Nicotine, Gender differences (Psychology), Substance abuse, Drinking behavior, Reward (Psychology), Neuropsychology, Therapeutics, Public health
Abstract: Rationale: Alcohol and nicotine are frequently co-used, with significant implications for public health, particularly for women. Nicotine is known to enhance the response to other reinforcers in the immediate environment, including alcohol. Although many studies have examined the potential intersections of alcohol and nicotine use, few have directly examined any potential sex differences in the ability of nicotine to potentiate the reward and reinforcement of alcohol. Objective: Summarize all extant evidence from clinical and preclinical studies that have investigated nicotine-induced enhancement of alcohol self-administration in male and/or female subjects, with a particular focus on studies that have directly assessed sex differences. Methods and results: We obtained relevant studies from PubMed and GoogleScholar, selecting only studies in which alcohol self-administration occurred under the influence of passively-administered nicotine. We identified five clinical studies and 20 preclinical studies that matched our inclusion criteria, and only a subset of those studies directly examined male and female subjects. Although the collected evidence from these studies is limited, we discuss substantial evidence from other studies exhibiting sex differences in the neuropsychobiological mechanisms by which nicotine can modulate alcohol-related behaviors. Conclusions: By highlighting the limited number of studies that have directly assessed sex differences in nicotine-induced enhancement of alcohol self-administration, we propose different avenues to address the gaps in the literature. Since rising rates of alcohol use disorder and nicotine-alcohol co-use disproportionately impact women, future research should prioritize mechanistic explorations and translational paradigms to tailor therapeutic strategies. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Clinical and preclinical evidence of sex differences in nicotine-induced enhancement of alcohol self-administration.
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  Data: <searchLink fieldCode="AR" term="%22Garcia-Rivas%2C+Vernon%22">Garcia-Rivas, Vernon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zakiniaeiz%2C+Yasmin%22">Zakiniaeiz, Yasmin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jimenez+Chavez%2C+C%2E+Leonardo%22">Jimenez Chavez, C. Leonardo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kohler%2C+Robert+J%2E%22">Kohler, Robert J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peltier%2C+MacKenzie+R%2E%22">Peltier, MacKenzie R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Raval%2C+Nakul+R%2E%22">Raval, Nakul R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verplaetse%2C+Terril+L%2E%22">Verplaetse, Terril L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Hang%22">Zhou, Hang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McKee%2C+Sherry+A%2E%22">McKee, Sherry A.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jul2026, Vol. 243 Issue 7, p1555-1568. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Nicotine%22">Nicotine</searchLink><br /><searchLink fieldCode="DE" term="%22Gender+differences+%28Psychology%29%22">Gender differences (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Substance+abuse%22">Substance abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Drinking+behavior%22">Drinking behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Reward+%28Psychology%29%22">Reward (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychology%22">Neuropsychology</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Public+health%22">Public health</searchLink>
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  Label: Abstract
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  Data: Rationale: Alcohol and nicotine are frequently co-used, with significant implications for public health, particularly for women. Nicotine is known to enhance the response to other reinforcers in the immediate environment, including alcohol. Although many studies have examined the potential intersections of alcohol and nicotine use, few have directly examined any potential sex differences in the ability of nicotine to potentiate the reward and reinforcement of alcohol. Objective: Summarize all extant evidence from clinical and preclinical studies that have investigated nicotine-induced enhancement of alcohol self-administration in male and/or female subjects, with a particular focus on studies that have directly assessed sex differences. Methods and results: We obtained relevant studies from PubMed and GoogleScholar, selecting only studies in which alcohol self-administration occurred under the influence of passively-administered nicotine. We identified five clinical studies and 20 preclinical studies that matched our inclusion criteria, and only a subset of those studies directly examined male and female subjects. Although the collected evidence from these studies is limited, we discuss substantial evidence from other studies exhibiting sex differences in the neuropsychobiological mechanisms by which nicotine can modulate alcohol-related behaviors. Conclusions: By highlighting the limited number of studies that have directly assessed sex differences in nicotine-induced enhancement of alcohol self-administration, we propose different avenues to address the gaps in the literature. Since rising rates of alcohol use disorder and nicotine-alcohol co-use disproportionately impact women, future research should prioritize mechanistic explorations and translational paradigms to tailor therapeutic strategies. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jul2026
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