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The Polycomb group protein EZH2 directly controls DNA methylation.

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Title: The Polycomb group protein EZH2 directly controls DNA methylation.
Authors: Viré, Emmanuelle, Brenner, Carmen, Deplus, Rachel, Blanchon, Loïc, Fraga, Mario, Didelot, Céline, Morey, Lluis, Van Eynde, Aleyde, Bernard, David, Vanderwinden, Jean-Marie, Bollen, Mathieu, Esteller, Manel, Di Croce, Luciano, de Launoit, Yvan, Fuks, François
Source: Nature. 2/16/2006, Vol. 439 Issue 7078, p871-874. 4p. 4 Graphs.
Subjects: Genetics, Gene silencing, Cell determination, Cell physiology, Proteins, Methylation
Abstract: The establishment and maintenance of epigenetic gene silencing is fundamental to cell determination and function. The essential epigenetic systems involved in heritable repression of gene activity are the Polycomb group (PcG) proteins and the DNA methylation systems. Here we show that the corresponding silencing pathways are mechanistically linked. We find that the PcG protein EZH2 (Enhancer of Zeste homolog 2) interacts—within the context of the Polycomb repressive complexes 2 and 3 (PRC2/3)—with DNA methyltransferases (DNMTs) and associates with DNMT activity in vivo. Chromatin immunoprecipitations indicate that binding of DNMTs to several EZH2-repressed genes depends on the presence of EZH2. Furthermore, we show by bisulphite genomic sequencing that EZH2 is required for DNA methylation of EZH2-target promoters. Our results suggest that EZH2 serves as a recruitment platform for DNA methyltransferases, thus highlighting a previously unrecognized direct connection between two key epigenetic repression systems. [ABSTRACT FROM AUTHOR]
Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The Polycomb group protein EZH2 directly controls DNA methylation.
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  Data: <searchLink fieldCode="AR" term="%22Viré%2C+Emmanuelle%22">Viré, Emmanuelle</searchLink><br /><searchLink fieldCode="AR" term="%22Brenner%2C+Carmen%22">Brenner, Carmen</searchLink><br /><searchLink fieldCode="AR" term="%22Deplus%2C+Rachel%22">Deplus, Rachel</searchLink><br /><searchLink fieldCode="AR" term="%22Blanchon%2C+Loïc%22">Blanchon, Loïc</searchLink><br /><searchLink fieldCode="AR" term="%22Fraga%2C+Mario%22">Fraga, Mario</searchLink><br /><searchLink fieldCode="AR" term="%22Didelot%2C+Céline%22">Didelot, Céline</searchLink><br /><searchLink fieldCode="AR" term="%22Morey%2C+Lluis%22">Morey, Lluis</searchLink><br /><searchLink fieldCode="AR" term="%22Van+Eynde%2C+Aleyde%22">Van Eynde, Aleyde</searchLink><br /><searchLink fieldCode="AR" term="%22Bernard%2C+David%22">Bernard, David</searchLink><br /><searchLink fieldCode="AR" term="%22Vanderwinden%2C+Jean-Marie%22">Vanderwinden, Jean-Marie</searchLink><br /><searchLink fieldCode="AR" term="%22Bollen%2C+Mathieu%22">Bollen, Mathieu</searchLink><br /><searchLink fieldCode="AR" term="%22Esteller%2C+Manel%22">Esteller, Manel</searchLink><br /><searchLink fieldCode="AR" term="%22Di+Croce%2C+Luciano%22">Di Croce, Luciano</searchLink><br /><searchLink fieldCode="AR" term="%22de+Launoit%2C+Yvan%22">de Launoit, Yvan</searchLink><br /><searchLink fieldCode="AR" term="%22Fuks%2C+François%22">Fuks, François</searchLink>
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  Data: The establishment and maintenance of epigenetic gene silencing is fundamental to cell determination and function. The essential epigenetic systems involved in heritable repression of gene activity are the Polycomb group (PcG) proteins and the DNA methylation systems. Here we show that the corresponding silencing pathways are mechanistically linked. We find that the PcG protein EZH2 (Enhancer of Zeste homolog 2) interacts—within the context of the Polycomb repressive complexes 2 and 3 (PRC2/3)—with DNA methyltransferases (DNMTs) and associates with DNMT activity in vivo. Chromatin immunoprecipitations indicate that binding of DNMTs to several EZH2-repressed genes depends on the presence of EZH2. Furthermore, we show by bisulphite genomic sequencing that EZH2 is required for DNA methylation of EZH2-target promoters. Our results suggest that EZH2 serves as a recruitment platform for DNA methyltransferases, thus highlighting a previously unrecognized direct connection between two key epigenetic repression systems. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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