View in EDS PDF Full Text

Cytotoxic therapy for severe avian influenza A (H5N1) infection.

Saved in:
Bibliographic Details
Title: Cytotoxic therapy for severe avian influenza A (H5N1) infection.
Authors: Henter, Jan-Inge, Chun-Bong Chow, Chi-Wai Leung, Yu-Lung Lau
Source: Lancet. 3/11/2006, Vol. 367 Issue 9513, p870-873. 4p. 1 Graph.
Subjects: Avian influenza treatment, Virus disease drug therapy, Disease complications, Zoonoses, Apoptosis, Multiple organ failure, Antineoplastic agents, Therapeutics research, Research methodology, Prevention
Abstract: Summary The mortality rate in documented avian influenza A virus subtype H5N1 infection is still high, which is currently reported by WHO at about 50%. Post-mortem analyses in affected patients have revealed haemophagocytosis similar to that found in patients with haemophagocytic lymphohistiocytosis (HLH); such haemophagocytosis could be a very prominent post-mortem feature in H5N1 infection. There are also clinical similarities between H5N1 infection and HLH, such as massive hypercytokinaemia, cytopenia, and acute encephalitis. Importantly, patients with another severe viral infection that may be complicated by secondary HLH, severe Epstein-Barr-virus-associated HLH, have significantly better survival if specific HLH therapy (including the cytotoxic and pro-apoptotic drug etoposide) is initiated early, with survival reported to rise from about 50% to 90%. With this notable improvement in survival, specific HLH treatment, including cytotoxic therapy, could be considered in patients with severe avian influenza A infection complicated by secondary HLH. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 20031044
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cytotoxic therapy for severe avian influenza A (H5N1) infection.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Henter%2C+Jan-Inge%22">Henter, Jan-Inge</searchLink><br /><searchLink fieldCode="AR" term="%22Chun-Bong+Chow%22">Chun-Bong Chow</searchLink><br /><searchLink fieldCode="AR" term="%22Chi-Wai+Leung%22">Chi-Wai Leung</searchLink><br /><searchLink fieldCode="AR" term="%22Yu-Lung+Lau%22">Yu-Lung Lau</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 3/11/2006, Vol. 367 Issue 9513, p870-873. 4p. 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Avian+influenza+treatment%22">Avian influenza treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Virus+disease+drug+therapy%22">Virus disease drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink><br /><searchLink fieldCode="DE" term="%22Zoonoses%22">Zoonoses</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+organ+failure%22">Multiple organ failure</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics+research%22">Therapeutics research</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Prevention%22">Prevention</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Summary The mortality rate in documented avian influenza A virus subtype H5N1 infection is still high, which is currently reported by WHO at about 50%. Post-mortem analyses in affected patients have revealed haemophagocytosis similar to that found in patients with haemophagocytic lymphohistiocytosis (HLH); such haemophagocytosis could be a very prominent post-mortem feature in H5N1 infection. There are also clinical similarities between H5N1 infection and HLH, such as massive hypercytokinaemia, cytopenia, and acute encephalitis. Importantly, patients with another severe viral infection that may be complicated by secondary HLH, severe Epstein-Barr-virus-associated HLH, have significantly better survival if specific HLH therapy (including the cytotoxic and pro-apoptotic drug etoposide) is initiated early, with survival reported to rise from about 50% to 90%. With this notable improvement in survival, specific HLH treatment, including cytotoxic therapy, could be considered in patients with severe avian influenza A infection complicated by secondary HLH. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=20031044
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/S0140-6736(06)68232-9
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 870
    Subjects:
      – SubjectFull: Avian influenza treatment
        Type: general
      – SubjectFull: Virus disease drug therapy
        Type: general
      – SubjectFull: Disease complications
        Type: general
      – SubjectFull: Zoonoses
        Type: general
      – SubjectFull: Apoptosis
        Type: general
      – SubjectFull: Multiple organ failure
        Type: general
      – SubjectFull: Antineoplastic agents
        Type: general
      – SubjectFull: Therapeutics research
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Prevention
        Type: general
    Titles:
      – TitleFull: Cytotoxic therapy for severe avian influenza A (H5N1) infection.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Henter, Jan-Inge
      – PersonEntity:
          Name:
            NameFull: Chun-Bong Chow
      – PersonEntity:
          Name:
            NameFull: Chi-Wai Leung
      – PersonEntity:
          Name:
            NameFull: Yu-Lung Lau
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 11
              M: 03
              Text: 3/11/2006
              Type: published
              Y: 2006
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 367
            – Type: issue
              Value: 9513
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1