View in EDS PDF Full Text

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

Saved in:
Bibliographic Details
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Authors: Zody, Michael C., Garber, Manuel, Adams, David J., Sharpe, Ted, Harrow, Jennifer, Lupski, James R., Nicholson, Christine, Searle, Steven M., Wilming, Laurens, Young, Sarah K., Abouelleil, Amr, Allen, Nicole R., Weimin Bi, Bloom, Toby, Borowsky, Mark L., Bugalter, Boris E., Butler, Jonathan, Chang, Jean L., Chao-Kung Chen, Cook, April
Source: Nature. 4/20/2006, Vol. 440 Issue 7087, p1045-1049. 5p. 1 Diagram, 1 Chart, 8 Graphs.
Subjects: Letters to the editor, Human chromosomes, Proteins, Genomes, Mammals
Abstract: Chromosome 17 is unusual among the human chromosomes in many respects. It is the largest human autosome with orthology to only a single mouse chromosome, mapping entirely to the distal half of mouse chromosome 11. Chromosome 17 is rich in protein-coding genes, having the second highest gene density in the genome. It is also enriched in segmental duplications, ranking third in density among the autosomes. Here we report a finished sequence for human chromosome 17, as well as a structural comparison with the finished sequence for mouse chromosome 11, the first finished mouse chromosome. Comparison of the orthologous regions reveals striking differences. In contrast to the typical pattern seen in mammalian evolution, the human sequence has undergone extensive intrachromosomal rearrangement, whereas the mouse sequence has been remarkably stable. Moreover, although the human sequence has a high density of segmental duplication, the mouse sequence has a very low density. Notably, these segmental duplications correspond closely to the sites of structural rearrangement, demonstrating a link between duplication and rearrangement. Examination of the main classes of duplicated segments provides insight into the dynamics underlying expansion of chromosome-specific, low-copy repeats in the human genome. [ABSTRACT FROM AUTHOR]
Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 20531721
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zody%2C+Michael+C%2E%22">Zody, Michael C.</searchLink><br /><searchLink fieldCode="AR" term="%22Garber%2C+Manuel%22">Garber, Manuel</searchLink><br /><searchLink fieldCode="AR" term="%22Adams%2C+David+J%2E%22">Adams, David J.</searchLink><br /><searchLink fieldCode="AR" term="%22Sharpe%2C+Ted%22">Sharpe, Ted</searchLink><br /><searchLink fieldCode="AR" term="%22Harrow%2C+Jennifer%22">Harrow, Jennifer</searchLink><br /><searchLink fieldCode="AR" term="%22Lupski%2C+James+R%2E%22">Lupski, James R.</searchLink><br /><searchLink fieldCode="AR" term="%22Nicholson%2C+Christine%22">Nicholson, Christine</searchLink><br /><searchLink fieldCode="AR" term="%22Searle%2C+Steven+M%2E%22">Searle, Steven M.</searchLink><br /><searchLink fieldCode="AR" term="%22Wilming%2C+Laurens%22">Wilming, Laurens</searchLink><br /><searchLink fieldCode="AR" term="%22Young%2C+Sarah+K%2E%22">Young, Sarah K.</searchLink><br /><searchLink fieldCode="AR" term="%22Abouelleil%2C+Amr%22">Abouelleil, Amr</searchLink><br /><searchLink fieldCode="AR" term="%22Allen%2C+Nicole+R%2E%22">Allen, Nicole R.</searchLink><br /><searchLink fieldCode="AR" term="%22Weimin+Bi%22">Weimin Bi</searchLink><br /><searchLink fieldCode="AR" term="%22Bloom%2C+Toby%22">Bloom, Toby</searchLink><br /><searchLink fieldCode="AR" term="%22Borowsky%2C+Mark+L%2E%22">Borowsky, Mark L.</searchLink><br /><searchLink fieldCode="AR" term="%22Bugalter%2C+Boris+E%2E%22">Bugalter, Boris E.</searchLink><br /><searchLink fieldCode="AR" term="%22Butler%2C+Jonathan%22">Butler, Jonathan</searchLink><br /><searchLink fieldCode="AR" term="%22Chang%2C+Jean+L%2E%22">Chang, Jean L.</searchLink><br /><searchLink fieldCode="AR" term="%22Chao-Kung+Chen%22">Chao-Kung Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Cook%2C+April%22">Cook, April</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 4/20/2006, Vol. 440 Issue 7087, p1045-1049. 5p. 1 Diagram, 1 Chart, 8 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Letters+to+the+editor%22">Letters to the editor</searchLink><br /><searchLink fieldCode="DE" term="%22Human+chromosomes%22">Human chromosomes</searchLink><br /><searchLink fieldCode="DE" term="%22Proteins%22">Proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Genomes%22">Genomes</searchLink><br /><searchLink fieldCode="DE" term="%22Mammals%22">Mammals</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Chromosome 17 is unusual among the human chromosomes in many respects. It is the largest human autosome with orthology to only a single mouse chromosome, mapping entirely to the distal half of mouse chromosome 11. Chromosome 17 is rich in protein-coding genes, having the second highest gene density in the genome. It is also enriched in segmental duplications, ranking third in density among the autosomes. Here we report a finished sequence for human chromosome 17, as well as a structural comparison with the finished sequence for mouse chromosome 11, the first finished mouse chromosome. Comparison of the orthologous regions reveals striking differences. In contrast to the typical pattern seen in mammalian evolution, the human sequence has undergone extensive intrachromosomal rearrangement, whereas the mouse sequence has been remarkably stable. Moreover, although the human sequence has a high density of segmental duplication, the mouse sequence has a very low density. Notably, these segmental duplications correspond closely to the sites of structural rearrangement, demonstrating a link between duplication and rearrangement. Examination of the main classes of duplicated segments provides insight into the dynamics underlying expansion of chromosome-specific, low-copy repeats in the human genome. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=20531721
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/nature04689
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 1045
    Subjects:
      – SubjectFull: Letters to the editor
        Type: general
      – SubjectFull: Human chromosomes
        Type: general
      – SubjectFull: Proteins
        Type: general
      – SubjectFull: Genomes
        Type: general
      – SubjectFull: Mammals
        Type: general
    Titles:
      – TitleFull: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zody, Michael C.
      – PersonEntity:
          Name:
            NameFull: Garber, Manuel
      – PersonEntity:
          Name:
            NameFull: Adams, David J.
      – PersonEntity:
          Name:
            NameFull: Sharpe, Ted
      – PersonEntity:
          Name:
            NameFull: Harrow, Jennifer
      – PersonEntity:
          Name:
            NameFull: Lupski, James R.
      – PersonEntity:
          Name:
            NameFull: Nicholson, Christine
      – PersonEntity:
          Name:
            NameFull: Searle, Steven M.
      – PersonEntity:
          Name:
            NameFull: Wilming, Laurens
      – PersonEntity:
          Name:
            NameFull: Young, Sarah K.
      – PersonEntity:
          Name:
            NameFull: Abouelleil, Amr
      – PersonEntity:
          Name:
            NameFull: Allen, Nicole R.
      – PersonEntity:
          Name:
            NameFull: Weimin Bi
      – PersonEntity:
          Name:
            NameFull: Bloom, Toby
      – PersonEntity:
          Name:
            NameFull: Borowsky, Mark L.
      – PersonEntity:
          Name:
            NameFull: Bugalter, Boris E.
      – PersonEntity:
          Name:
            NameFull: Butler, Jonathan
      – PersonEntity:
          Name:
            NameFull: Chang, Jean L.
      – PersonEntity:
          Name:
            NameFull: Chao-Kung Chen
      – PersonEntity:
          Name:
            NameFull: Cook, April
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 20
              M: 04
              Text: 4/20/2006
              Type: published
              Y: 2006
          Identifiers:
            – Type: issn-print
              Value: 00280836
          Numbering:
            – Type: volume
              Value: 440
            – Type: issue
              Value: 7087
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1