Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons.
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| Title: | Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons. |
|---|---|
| Authors: | Hartman, Kenichi N., Pal, Sumon K., Burrone, Juan, Murthy, Venkatesh N. |
| Source: | Nature Neuroscience. May2006, Vol. 9 Issue 5, p642-649. 8p. 8 Graphs. |
| Subjects: | Synapses, Neural transmission, Neurons, Neurophysiology, Neural circuitry |
| Abstract: | Neural activity regulates the number and properties of GABAergic synapses in the brain, but the mechanisms underlying these changes are unclear. We found that blocking spike activity globally in developing hippocampal neurons from rats reduced the density of GABAergic terminals as well as the frequency and amplitude of miniature inhibitory postsynaptic currents (mIPSCs). Chronic inactivity later in development led to a reduction in the mIPSC amplitude, without any change in GABAergic synapse density. By contrast, hyperpolarizing or abolishing spike activity in single neurons did not alter GABAergic synaptic inputs. Suppressing activity in individual presynaptic GABAergic neurons also failed to decrease synaptic output. Our results indicate that GABAergic synapses are regulated by the level of activity in surrounding neurons. Notably, we found that the expression of GABAergic plasticity involves changes in the amount of neurotransmitter in individual vesicles. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 20619840 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hartman%2C+Kenichi+N%2E%22">Hartman, Kenichi N.</searchLink><br /><searchLink fieldCode="AR" term="%22Pal%2C+Sumon+K%2E%22">Pal, Sumon K.</searchLink><br /><searchLink fieldCode="AR" term="%22Burrone%2C+Juan%22">Burrone, Juan</searchLink><br /><searchLink fieldCode="AR" term="%22Murthy%2C+Venkatesh+N%2E%22">Murthy, Venkatesh N.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. May2006, Vol. 9 Issue 5, p642-649. 8p. 8 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Synapses%22">Synapses</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Neurophysiology%22">Neurophysiology</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+circuitry%22">Neural circuitry</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Neural activity regulates the number and properties of GABAergic synapses in the brain, but the mechanisms underlying these changes are unclear. We found that blocking spike activity globally in developing hippocampal neurons from rats reduced the density of GABAergic terminals as well as the frequency and amplitude of miniature inhibitory postsynaptic currents (mIPSCs). Chronic inactivity later in development led to a reduction in the mIPSC amplitude, without any change in GABAergic synapse density. By contrast, hyperpolarizing or abolishing spike activity in single neurons did not alter GABAergic synaptic inputs. Suppressing activity in individual presynaptic GABAergic neurons also failed to decrease synaptic output. Our results indicate that GABAergic synapses are regulated by the level of activity in surrounding neurons. Notably, we found that the expression of GABAergic plasticity involves changes in the amount of neurotransmitter in individual vesicles. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nn1677 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 642 Subjects: – SubjectFull: Synapses Type: general – SubjectFull: Neural transmission Type: general – SubjectFull: Neurons Type: general – SubjectFull: Neurophysiology Type: general – SubjectFull: Neural circuitry Type: general Titles: – TitleFull: Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hartman, Kenichi N. – PersonEntity: Name: NameFull: Pal, Sumon K. – PersonEntity: Name: NameFull: Burrone, Juan – PersonEntity: Name: NameFull: Murthy, Venkatesh N. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 10976256 Numbering: – Type: volume Value: 9 – Type: issue Value: 5 Titles: – TitleFull: Nature Neuroscience Type: main |
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