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Atopic and Nonatopic Asthma in Children.

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Title: Atopic and Nonatopic Asthma in Children.
Authors: Bottini, N (AUTHOR), Ronchetti, F (AUTHOR), Gloria-Bottini, Fulvia (AUTHOR), Stefanini, L (AUTHOR), Bottini, Egidio (AUTHOR), Lucarini, N (AUTHOR)
Source: Journal of Asthma. Jan/Feb2005, Vol. 42 Issue 1, p25-28. 4p. 3 Charts.
Subjects: Asthma, Sialic acids, Bronchial diseases, Lung diseases, Respiratory allergy, Phenotypes
Abstract: In 155 asthmatic children we have studied the relationship between prick test positivity and a set of genetic factors previously found to be associated with bronchial asthma. Among these factors, MN system (p = 0.009) and age at onset of symptoms (p = 0.05) are the most important variables separating prick test negative from prick test positive children. MN and age at onset influence independently prick test positivity pointing to an additive effect of the two variables. M phenotype appears correlated positively with an increased susceptibility to nonallergic asthma in all age groups, whereas N phenotype appears correlated positively with age at onset but in allergic asthma only. The MN system codifies for glycophorin A, a sialoglycoprotein that represents a major ligand for several bacteria and viruses that recognize the N-acetylneuraminic acid present in this protein. The present data suggest that genetic variability in this system might influence bacterial and viral competition and mucosal damage influencing susceptibility to asthmatic reactions in absence of IgE hyperproduction. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Atopic and Nonatopic Asthma in Children.
– Name: Author
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  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bottini%2C+N%22">Bottini, N</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ronchetti%2C+F%22">Ronchetti, F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gloria-Bottini%2C+Fulvia%22">Gloria-Bottini, Fulvia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stefanini%2C+L%22">Stefanini, L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bottini%2C+Egidio%22">Bottini, Egidio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lucarini%2C+N%22">Lucarini, N</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Asthma%22">Journal of Asthma</searchLink>. Jan/Feb2005, Vol. 42 Issue 1, p25-28. 4p. 3 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Asthma%22">Asthma</searchLink><br /><searchLink fieldCode="DE" term="%22Sialic+acids%22">Sialic acids</searchLink><br /><searchLink fieldCode="DE" term="%22Bronchial+diseases%22">Bronchial diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+diseases%22">Lung diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+allergy%22">Respiratory allergy</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In 155 asthmatic children we have studied the relationship between prick test positivity and a set of genetic factors previously found to be associated with bronchial asthma. Among these factors, MN system (p = 0.009) and age at onset of symptoms (p = 0.05) are the most important variables separating prick test negative from prick test positive children. MN and age at onset influence independently prick test positivity pointing to an additive effect of the two variables. M phenotype appears correlated positively with an increased susceptibility to nonallergic asthma in all age groups, whereas N phenotype appears correlated positively with age at onset but in allergic asthma only. The MN system codifies for glycophorin A, a sialoglycoprotein that represents a major ligand for several bacteria and viruses that recognize the N-acetylneuraminic acid present in this protein. The present data suggest that genetic variability in this system might influence bacterial and viral competition and mucosal damage influencing susceptibility to asthmatic reactions in absence of IgE hyperproduction. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1081/JAS-200044756
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 25
    Subjects:
      – SubjectFull: Asthma
        Type: general
      – SubjectFull: Sialic acids
        Type: general
      – SubjectFull: Bronchial diseases
        Type: general
      – SubjectFull: Lung diseases
        Type: general
      – SubjectFull: Respiratory allergy
        Type: general
      – SubjectFull: Phenotypes
        Type: general
    Titles:
      – TitleFull: Atopic and Nonatopic Asthma in Children.
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          Name:
            NameFull: Bottini, N
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          Name:
            NameFull: Ronchetti, F
      – PersonEntity:
          Name:
            NameFull: Gloria-Bottini, Fulvia
      – PersonEntity:
          Name:
            NameFull: Stefanini, L
      – PersonEntity:
          Name:
            NameFull: Bottini, Egidio
      – PersonEntity:
          Name:
            NameFull: Lucarini, N
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            – D: 01
              M: 01
              Text: Jan/Feb2005
              Type: published
              Y: 2005
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              Value: 02770903
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              Value: 42
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            – TitleFull: Journal of Asthma
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