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Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice.

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Title: Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice.
Authors: Takahashi, Kuniyuki (AUTHOR), Hishida, Ryuichi (AUTHOR), Kubota, Yamato (AUTHOR), Kudoh, Masaharu (AUTHOR), Takahashi, Sugata (AUTHOR), Shibuki, Katsuei (AUTHOR)
Source: European Journal of Neuroscience. Mar2006, Vol. 23 Issue 5, p1365-1376. 12p. 19 Diagrams, 15 Graphs.
Subjects: Auditory cortex, Fluorescence, Brain, Skull, Material plasticity, Mice
Abstract: Functional brain imaging using endogenous fluorescence of mitochondrial flavoprotein is useful for investigating mouse cortical activities via the intact skull, which is thin and sufficiently transparent in mice. We applied this method to investigate auditory cortical plasticity regulated by acoustic environments. Normal mice of the C57BL/6 strain, reared in various acoustic environments for at least 4 weeks after birth, were anaesthetized with urethane (1.7 g/kg, i.p.). Auditory cortical images of endogenous green fluorescence in blue light were recorded by a cooled CCD camera via the intact skull. Cortical responses elicited by tonal stimuli (5, 10 and 20 kHz) exhibited mirror-symmetrical tonotopic maps in the primary auditory cortex (AI) and anterior auditory field (AAF). Depression of auditory cortical responses regarding response duration was observed in sound-deprived mice compared with naïve mice reared in a normal acoustic environment. When mice were exposed to an environmental tonal stimulus at 10 kHz for more than 4 weeks after birth, the cortical responses were potentiated in a frequency-specific manner in respect to peak amplitude of the responses in AI, but not for the size of the responsive areas. Changes in AAF were less clear than those in AI. To determine the modified synapses by acoustic environments, neural responses in cortical slices were investigated with endogenous fluorescence imaging. The vertical thickness of responsive areas after supragranular electrical stimulation was significantly reduced in the slices obtained from sound-deprived mice. These results suggest that acoustic environments regulate the development of vertical intracortical circuits in the mouse auditory cortex. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Group: Ti
  Data: Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice.
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  Data: <searchLink fieldCode="AR" term="%22Takahashi%2C+Kuniyuki%22">Takahashi, Kuniyuki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hishida%2C+Ryuichi%22">Hishida, Ryuichi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kubota%2C+Yamato%22">Kubota, Yamato</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kudoh%2C+Masaharu%22">Kudoh, Masaharu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Takahashi%2C+Sugata%22">Takahashi, Sugata</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shibuki%2C+Katsuei%22">Shibuki, Katsuei</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Mar2006, Vol. 23 Issue 5, p1365-1376. 12p. 19 Diagrams, 15 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Auditory+cortex%22">Auditory cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescence%22">Fluorescence</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Skull%22">Skull</searchLink><br /><searchLink fieldCode="DE" term="%22Material+plasticity%22">Material plasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Functional brain imaging using endogenous fluorescence of mitochondrial flavoprotein is useful for investigating mouse cortical activities via the intact skull, which is thin and sufficiently transparent in mice. We applied this method to investigate auditory cortical plasticity regulated by acoustic environments. Normal mice of the C57BL/6 strain, reared in various acoustic environments for at least 4 weeks after birth, were anaesthetized with urethane (1.7 g/kg, i.p.). Auditory cortical images of endogenous green fluorescence in blue light were recorded by a cooled CCD camera via the intact skull. Cortical responses elicited by tonal stimuli (5, 10 and 20 kHz) exhibited mirror-symmetrical tonotopic maps in the primary auditory cortex (AI) and anterior auditory field (AAF). Depression of auditory cortical responses regarding response duration was observed in sound-deprived mice compared with naïve mice reared in a normal acoustic environment. When mice were exposed to an environmental tonal stimulus at 10 kHz for more than 4 weeks after birth, the cortical responses were potentiated in a frequency-specific manner in respect to peak amplitude of the responses in AI, but not for the size of the responsive areas. Changes in AAF were less clear than those in AI. To determine the modified synapses by acoustic environments, neural responses in cortical slices were investigated with endogenous fluorescence imaging. The vertical thickness of responsive areas after supragranular electrical stimulation was significantly reduced in the slices obtained from sound-deprived mice. These results suggest that acoustic environments regulate the development of vertical intracortical circuits in the mouse auditory cortex. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1460-9568.2006.04662.x
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              Text: Mar2006
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