Inflammation and excitotoxicity: role in migraine pathogenesis.
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| Title: | Inflammation and excitotoxicity: role in migraine pathogenesis. |
|---|---|
| Authors: | Longoni, M., Ferrarese, C. |
| Source: | Neurological Sciences. May2006 Supplement 2, Vol. 27, ps107-s110. 1p. |
| Subjects: | Migraine, Inflammation, Nitric oxide, Cytokines, Calcitonin |
| Abstract: | The pathogenesis of migraine is still unclear, but much evidence suggests a role of inflammation in pain generation. Calcitonin gene related peptide, nitric oxide and cytokines are all molecules shown to be involved both in animal and human studies. The glutamatergic system is also described as a possible mechanism leading to neuronal hyperexcitability and cortical spreading depression (CSD). Excitotoxic neural death, due to excessive release of the amino acid in the extracellular space, may represent a consequence of protracted CSD and oligaemia and may be involved in migrainous infarction and aspecific lesions seen on T2-weighted NMR imaging. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 20786027 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Inflammation and excitotoxicity: role in migraine pathogenesis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Longoni%2C+M%2E%22">Longoni, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ferrarese%2C+C%2E%22">Ferrarese, C.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2006 Supplement 2, Vol. 27, ps107-s110. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Nitric+oxide%22">Nitric oxide</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22Calcitonin%22">Calcitonin</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The pathogenesis of migraine is still unclear, but much evidence suggests a role of inflammation in pain generation. Calcitonin gene related peptide, nitric oxide and cytokines are all molecules shown to be involved both in animal and human studies. The glutamatergic system is also described as a possible mechanism leading to neuronal hyperexcitability and cortical spreading depression (CSD). Excitotoxic neural death, due to excessive release of the amino acid in the extracellular space, may represent a consequence of protracted CSD and oligaemia and may be involved in migrainous infarction and aspecific lesions seen on T2-weighted NMR imaging. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=20786027 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-006-0582-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: s107 Subjects: – SubjectFull: Migraine Type: general – SubjectFull: Inflammation Type: general – SubjectFull: Nitric oxide Type: general – SubjectFull: Cytokines Type: general – SubjectFull: Calcitonin Type: general Titles: – TitleFull: Inflammation and excitotoxicity: role in migraine pathogenesis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Longoni, M. – PersonEntity: Name: NameFull: Ferrarese, C. IsPartOfRelationships: – BibEntity: Dates: – D: 03 M: 05 Text: May2006 Supplement 2 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 27 Titles: – TitleFull: Neurological Sciences Type: main |
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