View in EDS HTML Full Text PDF Full Text

Voxel-based statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: Group and individual analyses.

Saved in:
Bibliographic Details
Title: Voxel-based statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: Group and individual analyses.
Authors: Shin, Yong Beom (AUTHOR), Kim, Seong-Jang (AUTHOR), Kim, In-Ju (AUTHOR), Kim, Yong-Ki (AUTHOR), Kim, Dong-Soo (AUTHOR), Park, Jae Heung (AUTHOR), Yeom, Seok-Ran (AUTHOR)
Source: Brain Injury. Jun2006, Vol. 20 Issue 6, p661-667. 7p. 1 Diagram, 3 Charts.
Subjects: Brain injuries, Tomography, Medical radiography, Patients, Blood
Abstract: Purpose : Statistical parametric mapping (SPM) was applied to brain perfusion single photon emission computed tomography (SPECT) images in patients with traumatic brain injury (TBI) to investigate regional cerebral abnormalities compared to age-matched normal controls. Method : Thirteen patients with TBI underwent brain perfusion SPECT were included in this study (10 males, three females, mean age 39.8  ±  18.2, range 21  ∼⃒  74). SPM2 software implemented in MATLAB 5.3 was used for spatial pre-processing and analysis and to determine the quantitative differences between TBI patients and age-matched normal controls. Results : Three large voxel clusters of significantly decreased cerebral blood perfusion were found in patients with TBI. The largest clusters were area including medial frontal gyrus (voxel number 3642, peak Z -value  =  4.31, 4.27, p   =  0.000) in both hemispheres. The second largest clusters were areas including cingulated gyrus and anterior cingulate gyrus of left hemisphere (voxel number 381, peak Z -value  =  3.67, 3.62, p   =  0.000). Other clusters were parahippocampal gyrus (voxel number 173, peak Z -value  =  3.40, p   =  0.000) and hippocampus (voxel number 173, peak Z -value  =  3.23, p   =  0.001) in the left hemisphere. The false discovery rate (FDR) was less than 0.04. Conclusion : From this study, group and individual analyses of SPM2 could clearly identify the perfusion abnormalities of brain SPECT in patients with TBI. Group analysis of SPM2 showed hypoperfusion pattern in the areas including medial frontal gyrus of both hemispheres, cingulate gyrus, anterior cingulate gyrus, parahippocampal gyrus and hippocampus in the left hemisphere compared to age-matched normal controls. Also, left parahippocampal gyrus and left hippocampus were additional hypoperfusion areas. However, these findings deserve further investigation on a larger number of patients to be performed to allow a better validation of objective SPM analysis in patients with TBI. [ABSTRACT FROM AUTHOR]
Copyright of Brain Injury is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 21011271
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Voxel-based statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: Group and individual analyses.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Shin%2C+Yong+Beom%22">Shin, Yong Beom</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Seong-Jang%22">Kim, Seong-Jang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+In-Ju%22">Kim, In-Ju</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Yong-Ki%22">Kim, Yong-Ki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Dong-Soo%22">Kim, Dong-Soo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Jae+Heung%22">Park, Jae Heung</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yeom%2C+Seok-Ran%22">Yeom, Seok-Ran</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Brain+Injury%22">Brain Injury</searchLink>. Jun2006, Vol. 20 Issue 6, p661-667. 7p. 1 Diagram, 3 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Brain+injuries%22">Brain injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Tomography%22">Tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+radiography%22">Medical radiography</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink><br /><searchLink fieldCode="DE" term="%22Blood%22">Blood</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose : Statistical parametric mapping (SPM) was applied to brain perfusion single photon emission computed tomography (SPECT) images in patients with traumatic brain injury (TBI) to investigate regional cerebral abnormalities compared to age-matched normal controls. Method : Thirteen patients with TBI underwent brain perfusion SPECT were included in this study (10 males, three females, mean age 39.8  ±  18.2, range 21  ∼⃒  74). SPM2 software implemented in MATLAB 5.3 was used for spatial pre-processing and analysis and to determine the quantitative differences between TBI patients and age-matched normal controls. Results : Three large voxel clusters of significantly decreased cerebral blood perfusion were found in patients with TBI. The largest clusters were area including medial frontal gyrus (voxel number 3642, peak Z -value  =  4.31, 4.27, p   =  0.000) in both hemispheres. The second largest clusters were areas including cingulated gyrus and anterior cingulate gyrus of left hemisphere (voxel number 381, peak Z -value  =  3.67, 3.62, p   =  0.000). Other clusters were parahippocampal gyrus (voxel number 173, peak Z -value  =  3.40, p   =  0.000) and hippocampus (voxel number 173, peak Z -value  =  3.23, p   =  0.001) in the left hemisphere. The false discovery rate (FDR) was less than 0.04. Conclusion : From this study, group and individual analyses of SPM2 could clearly identify the perfusion abnormalities of brain SPECT in patients with TBI. Group analysis of SPM2 showed hypoperfusion pattern in the areas including medial frontal gyrus of both hemispheres, cingulate gyrus, anterior cingulate gyrus, parahippocampal gyrus and hippocampus in the left hemisphere compared to age-matched normal controls. Also, left parahippocampal gyrus and left hippocampus were additional hypoperfusion areas. However, these findings deserve further investigation on a larger number of patients to be performed to allow a better validation of objective SPM analysis in patients with TBI. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Brain Injury is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=21011271
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/02699050600677071
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 661
    Subjects:
      – SubjectFull: Brain injuries
        Type: general
      – SubjectFull: Tomography
        Type: general
      – SubjectFull: Medical radiography
        Type: general
      – SubjectFull: Patients
        Type: general
      – SubjectFull: Blood
        Type: general
    Titles:
      – TitleFull: Voxel-based statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: Group and individual analyses.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Shin, Yong Beom
      – PersonEntity:
          Name:
            NameFull: Kim, Seong-Jang
      – PersonEntity:
          Name:
            NameFull: Kim, In-Ju
      – PersonEntity:
          Name:
            NameFull: Kim, Yong-Ki
      – PersonEntity:
          Name:
            NameFull: Kim, Dong-Soo
      – PersonEntity:
          Name:
            NameFull: Park, Jae Heung
      – PersonEntity:
          Name:
            NameFull: Yeom, Seok-Ran
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2006
              Type: published
              Y: 2006
          Identifiers:
            – Type: issn-print
              Value: 02699052
          Numbering:
            – Type: volume
              Value: 20
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Brain Injury
              Type: main
ResultId 1