View in EDS PDF Full Text

Parkinson's disease: the genetics of a heterogeneous disorder.

Saved in:
Bibliographic Details
Title: Parkinson's disease: the genetics of a heterogeneous disorder.
Authors: Gosal, D., Ross, O. A., Toft, M.
Source: European Journal of Neurology. Jun2006, Vol. 13 Issue 6, p616-627. 12p. 7 Color Photographs, 2 Diagrams, 1 Chart.
Subjects: Parkinson's disease & genetics, Brain diseases, Extrapyramidal disorders, Neurodegeneration, Genes
Abstract: Since the first description of Parkinson's disease (PD) in 1817 attempts have been made to resolve the etiology of this common neurodegenerative disorder. In the last century the influence of heredity in PD was controversial. The identification of mutations in six genes responsible for Mendelian forms of PD; α- synuclein ( SNCA), parkin ( PRKN), ubiquitin C-terminal hydrolase L1 ( UCH-L1), oncogene DJ-1, PTEN-induced putative kinase 1 ( PINK1), and most recently leucine-rich repeat kinase 2 ( LRRK2), has confirmed the role of genetics in familial forms of the disease. The exact relationship of these familial disorders and related genes to the more common sporadic form is currently uncertain. The identification of LRRK2 mutations and the association of common variants in SNCA and UCH-L1 in apparently sporadic late-onset disease indicate these genes may be of greater importance than previously believed. The protein products of the six genes are involved in different pathways of neurodegeneration and have opened new avenues of research. This focused research will lead to the development of novel targeted therapies, which may revolutionize the treatment of PD for a substantial proportion of patients. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 21064192
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Parkinson's disease: the genetics of a heterogeneous disorder.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Gosal%2C+D%2E%22">Gosal, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Ross%2C+O%2E+A%2E%22">Ross, O. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Toft%2C+M%2E%22">Toft, M.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jun2006, Vol. 13 Issue 6, p616-627. 12p. 7 Color Photographs, 2 Diagrams, 1 Chart.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease+%26+genetics%22">Parkinson's disease & genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+diseases%22">Brain diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Extrapyramidal+disorders%22">Extrapyramidal disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodegeneration%22">Neurodegeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Since the first description of Parkinson's disease (PD) in 1817 attempts have been made to resolve the etiology of this common neurodegenerative disorder. In the last century the influence of heredity in PD was controversial. The identification of mutations in six genes responsible for Mendelian forms of PD; α- synuclein ( SNCA), parkin ( PRKN), ubiquitin C-terminal hydrolase L1 ( UCH-L1), oncogene DJ-1, PTEN-induced putative kinase 1 ( PINK1), and most recently leucine-rich repeat kinase 2 ( LRRK2), has confirmed the role of genetics in familial forms of the disease. The exact relationship of these familial disorders and related genes to the more common sporadic form is currently uncertain. The identification of LRRK2 mutations and the association of common variants in SNCA and UCH-L1 in apparently sporadic late-onset disease indicate these genes may be of greater importance than previously believed. The protein products of the six genes are involved in different pathways of neurodegeneration and have opened new avenues of research. This focused research will lead to the development of novel targeted therapies, which may revolutionize the treatment of PD for a substantial proportion of patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=21064192
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/j.1468-1331.2006.01336.x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 616
    Subjects:
      – SubjectFull: Parkinson's disease & genetics
        Type: general
      – SubjectFull: Brain diseases
        Type: general
      – SubjectFull: Extrapyramidal disorders
        Type: general
      – SubjectFull: Neurodegeneration
        Type: general
      – SubjectFull: Genes
        Type: general
    Titles:
      – TitleFull: Parkinson's disease: the genetics of a heterogeneous disorder.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Gosal, D.
      – PersonEntity:
          Name:
            NameFull: Ross, O. A.
      – PersonEntity:
          Name:
            NameFull: Toft, M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2006
              Type: published
              Y: 2006
          Identifiers:
            – Type: issn-print
              Value: 13515101
          Numbering:
            – Type: volume
              Value: 13
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: European Journal of Neurology
              Type: main
ResultId 1