Parietal white matter abnormalities in obsessive–compulsive disorder: a magnetic resonance spectroscopy study at 3-Tesla.
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| Title: | Parietal white matter abnormalities in obsessive–compulsive disorder: a magnetic resonance spectroscopy study at 3-Tesla. |
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| Authors: | Kitamura, H. (AUTHOR), Shioiri, T. (AUTHOR), Kimura, T. (AUTHOR), Ohkubo, M. (AUTHOR), Nakada, T. (AUTHOR), Someya, T. (AUTHOR) |
| Source: | Acta Psychiatrica Scandinavica. Aug2006, Vol. 114 Issue 2, p101-108. 8p. |
| Subjects: | Obsessive-compulsive disorder, Axons, Magnetic resonance, Creatine, Phospholipids |
| Abstract: | Objective: To identify a neurochemical basis for the hypothesis that an aberrant cortico-subcortical circuit underlies obsessive–compulsive disorder (OCD). The white matter was also investigated because of recent research which suggests the altered connectivity of axons. Method: Using 3-Tesla magnetic resonance spectroscopy, the relative concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) to creatine/phosphocreatine (Cr) were measured in the anterior cingulate, basal ganglia, thalamus, frontal and parietal white matter of 12 OCD patients, and 32 control subjects. Results: The mean concentration of Cho/Cr was significantly higher in the patients than in the controls, but only in the parietal white matter, while no significant group differences in NAA/Cr were observed in any of the brain regions. Parietal Cho/Cr correlated positively with the severity of OCD symptoms. Conclusion: This finding provides indirect evidence for the parietal white matter involvement in OCD, thus suggesting a change in the phospholipids of myelinated axons and/or glia cells. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective: To identify a neurochemical basis for the hypothesis that an aberrant cortico-subcortical circuit underlies obsessive–compulsive disorder (OCD). The white matter was also investigated because of recent research which suggests the altered connectivity of axons. Method: Using 3-Tesla magnetic resonance spectroscopy, the relative concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) to creatine/phosphocreatine (Cr) were measured in the anterior cingulate, basal ganglia, thalamus, frontal and parietal white matter of 12 OCD patients, and 32 control subjects. Results: The mean concentration of Cho/Cr was significantly higher in the patients than in the controls, but only in the parietal white matter, while no significant group differences in NAA/Cr were observed in any of the brain regions. Parietal Cho/Cr correlated positively with the severity of OCD symptoms. Conclusion: This finding provides indirect evidence for the parietal white matter involvement in OCD, thus suggesting a change in the phospholipids of myelinated axons and/or glia cells. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 0001690X |
| DOI: | 10.1111/j.1600-0447.2006.00858.x |
