The impact of the CYP2D6-polymorphism on dose recommendations for current antidepressants.
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| Title: | The impact of the CYP2D6-polymorphism on dose recommendations for current antidepressants. |
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| Authors: | Thuerauf, Norbert, Lunkenheimer, Jens |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. 2006, Vol. 256 Issue 5, p287-293. 7p. 1 Chart. |
| Subjects: | Cytochrome P-450, Metabolism, Chromosome polymorphism, Antidepressants, Metalloenzymes |
| Abstract: | Cytochrome P450 CYP2D6 represents an extensively characterized polymorphic drug-metabolizing enzyme. The CYP2D6-gene is highly polymorphic and more than 70 different alleles are known currently. The activity of the enzyme markedly varies among individuals from poor to intermediate and extensive up to ultrarapid metabolism on the basis of the polymorphism of the CYP2D6 gene. Association studies provide growing evidence for the clinical importance of the CYP2D6 polymorphism investigating whether the CYP2D6 genotype distribution differs from that of the normal population either in patients with marked adverse effects or in nonresponders during treatment with CYP2D6 substrates. However, these scientifically important studies present less information for dose adjustments necessary to individualize pharmacotherapy in a given clinical case. With respect to psychopharmacological drug metabolism several antidepressants were characterized as being CYP2D6 substrates. Thus, this review summarizes dose recommendations of current antidepressants. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 22054941 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The impact of the CYP2D6-polymorphism on dose recommendations for current antidepressants. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Thuerauf%2C+Norbert%22">Thuerauf, Norbert</searchLink><br /><searchLink fieldCode="AR" term="%22Lunkenheimer%2C+Jens%22">Lunkenheimer, Jens</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. 2006, Vol. 256 Issue 5, p287-293. 7p. 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cytochrome+P-450%22">Cytochrome P-450</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolism%22">Metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Chromosome+polymorphism%22">Chromosome polymorphism</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Metalloenzymes%22">Metalloenzymes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Cytochrome P450 CYP2D6 represents an extensively characterized polymorphic drug-metabolizing enzyme. The CYP2D6-gene is highly polymorphic and more than 70 different alleles are known currently. The activity of the enzyme markedly varies among individuals from poor to intermediate and extensive up to ultrarapid metabolism on the basis of the polymorphism of the CYP2D6 gene. Association studies provide growing evidence for the clinical importance of the CYP2D6 polymorphism investigating whether the CYP2D6 genotype distribution differs from that of the normal population either in patients with marked adverse effects or in nonresponders during treatment with CYP2D6 substrates. However, these scientifically important studies present less information for dose adjustments necessary to individualize pharmacotherapy in a given clinical case. With respect to psychopharmacological drug metabolism several antidepressants were characterized as being CYP2D6 substrates. Thus, this review summarizes dose recommendations of current antidepressants. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-006-0663-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 287 Subjects: – SubjectFull: Cytochrome P-450 Type: general – SubjectFull: Metabolism Type: general – SubjectFull: Chromosome polymorphism Type: general – SubjectFull: Antidepressants Type: general – SubjectFull: Metalloenzymes Type: general Titles: – TitleFull: The impact of the CYP2D6-polymorphism on dose recommendations for current antidepressants. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Thuerauf, Norbert – PersonEntity: Name: NameFull: Lunkenheimer, Jens IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 256 – Type: issue Value: 5 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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